Mifepristone Versus Laminaria Insertion for Cervical Preparation Prior to Surgical Abortion at 14-16 Weeks

Completed 50 enrolled Boston University Society of Family Planning · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

Women who are requesting pregnancy termination at 14-16 weeks, who would normally have osmotic dilator insertion the day before their procedure, would be asked if they wanted to participate. Participants would be randomized to two groups: first, dilator insertion as usual, or second, mifepristone taken the day before the procedure.

Timeline

Start: 2009-10
Primary completion: 2011-03
Completion: 2011-03

Outcome

Met primary endpoint

paper CONCLUSION: Mifepristone did not increase the time for abortion by more than the prespecified margin (3 min). PMID 22682721 ↗

Publications

Borgatta L, Roncari D, Sonalkar S, Mark A, Hou MY, Finneseth M, Vragovic O. Mifepristone vs. osmotic dilator insertion for cervical preparation prior to surgical abortion at 14-16 weeks: a randomized trial. Contraception. 2012 Nov;86(5):567-71. doi: 10.1016/j.contraception.2012.05.002. Epub 2012 Jun 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Mifepristone	Small molecule	200 mg	Oral

Indications

No indication recorded.