drugset / Trial / NCT00989703
GLPG0259 Multiple Ascending Dose and Methotrexate Drug-drug Interaction (DDI) in Healthy Subjects
RandomizedParallel-groupQuadruple-blind
Summary
The purpose of the study is to evaluate the safety and tolerability of multiple increasing oral doses of GLPG0259 compared to placebo. Also, pharmacokinetics (PK) and pharmacodynamics (PD) of GLPG0259 after multiple increasing oral doses, and potential drug-drug interaction with single dose methotrexate will be assessed.
Timeline
- Start
- 2009-09
- Primary completion
- 2009-11
- Completion
- 2010-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | GLPG0259 | Small molecule | 25 mg | Oral |
| Subject | GLPG0259 | Small molecule | 50 mg | Oral |
| Subject | GLPG0259 | Small molecule | 75 mg | Oral |
| Subject | Methotrexate | Small molecule | 7.5 mg | — |
Indications
No indication recorded.