Study of Vitamin D Supplementation to Male HIV Sero-positive Patients

Summary

The investigators want to investigate if HIV sero-positive males benefit from vitamin D supplementation. The study runs in 16 weeks and the participants are treated with one of three placebo controlled regimes (tablets): 1. Calcium 2. Calcium and 25-hydroxy-vitamin D 3. Calcium and 25-hydroxy-vitamin D and 1,25-dihydroxyvitamin D The endpoints are: * Serum vitamin D * Parathyroid hormone * ionized calcium * T-lymphocyte fractions (naïve, mature, Tregs) * Osteocalcin (bone metabolism)

Timeline

Start

2008-04

Primary completion

2010-02

Completion

2011-01

Publications

• Bang U, Kolte L, Hitz M, Dam Nielsen S, Schierbeck LL, Andersen O, Haugaard SB, Mathiesen L, Benfield T, Jensen JE. Correlation of increases in 1,25-dihydroxyvitamin D during vitamin D therapy with activation of CD4+ T lymphocytes in HIV-1-infected males. HIV Clin Trials. 2012 May-Jun;13(3):162-70. doi: 10.1310/hct1303-162.

Drugs

Indications