A Weight Loss Study in Overweight Men and Women

Summary

The purpose of this study is to determine if LY377604 + sibutramine work better than LY377604 or sibutramine alone in the treatment of obesity.

Timeline

Start

2009-10

Primary completion

2010-06

Completion

2010-06

Outcome

Missed primary endpoint

Stopped: “Clinical trial terminated due to results from recent nonclinical studies”

registry analysis (superiority or other test); LY377604 (75 mg) vs LY377604 (15 mg)/Sibutramine (30 mg); p <0.001; Mixed Models Analysis NCT00993421 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	LY377604	Small molecule	15 mg	Oral
Subject	LY377604	Small molecule	40 mg	Oral
Subject	LY377604	Small molecule	75 mg	Oral
Comparator	Metoprolol	Other / unclassified	200 mg	Oral
Subject	Sibutramine	Small molecule	15 mg	Oral
Subject	Sibutramine	Small molecule	30 mg	Oral

Indications