Efficacy and Tolerability of Saxagliptin add-on Compared to Uptitration of Metformin in Patients With Type 2 Diabetes

Phase 4 Completed 286 enrolled AstraZeneca Bristol-Myers Squibb · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

The study will evaluate the efficacy and tolerability of saxagliptin compared to uptitration of metformin in patients with type 2 diabetes who have inadequate glycaemic control on a submaximal dose of metformin.

Timeline

Start: 2009-10
Primary completion: —
Completion: 2010-12

Publications

Hermans MP, Delibasi T, Farmer I, Lohm L, Maheux P, Piatti P, Malvolti E, Jorgens S, Charbonnel B. Effects of saxagliptin added to sub-maximal doses of metformin compared with uptitration of metformin in type 2 diabetes: the PROMPT study. Curr Med Res Opin. 2012 Oct;28(10):1635-45. doi: 10.1185/03007995.2012.735646. Epub 2012 Oct 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Metformin	Small molecule	500 mg	Oral
Comparator	Metformin	Small molecule	1000 mg	Oral
Subject	SAXAGLIPTIN ANHYDROUS	Small molecule	5 mg	Oral

Efficacy and Tolerability of Saxagliptin add-on Compared to Uptitration of Metformin in Patients With Type 2 Diabetes

Summary

Timeline

Publications

Drugs

Indications