Dexmedetomidine Sedation With Third Molar Surgery
Summary
Intravenous sedation is used frequently for the relief of pain and anxiety associated with oral surgical procedures performed under local anesthesia. The purpose of this study is to learn about patient and surgeon satisfaction with sedation using Dexmedetomidine in combination with midazolam alone or with midazolam plus low dose ketamine while having wisdom teeth removed. The sedation produced by dexmedetomidine is unique in that it mimics natural sleep, a unique quality not shared by other drugs. Dexmedetomidine is often used in anesthesia in hospital operating rooms and has been approved by the US Food and Drug Administration for the use planned in this study.
Timeline
- Start
- 2009-07
- Primary completion
- 2011-12
- Completion
- 2011-12
Outcome
Outcome not reported
Stopped: “Protocol proved to be ineffective for adequate sedation for third molar surgery.”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dexmedetomidine | Other / unclassified | 0.5 ug/kg | Intravenous |
| Comparator | Ketamine | Small molecule | 0.25 mg/kg | Intravenous |
| Comparator | Midazolam | Small molecule | 0.04 mg/kg | Intravenous |
Indications
No indication recorded.