Zurich Disability Prevention Trial

Phase 2 Completed 200 enrolled University of Zurich

RandomizedParallel-groupQuadruple-blindPrevention

Summary

This project was designed to optimizing vitamin D status in prefrail seniors age 70+ living at home and prevent their functional decline. We test 3 arms of monthly vitamin D supplementation. Intermittent dosing will improve adherence and simplify vitamin D supplementation.

Timeline

Start: 2010-01
Primary completion: 2011-11
Completion: 2011-12

Publications

Braendle K, Egli A, Bischoff-Ferrari H, Freystaetter G. Does living alone influence fall risk among Swiss older adults aged 60+? A pooled observational analysis of three RCTs on fall prevention. BMJ Open. 2024 May 20;14(5):e081413. doi: 10.1136/bmjopen-2023-081413.
Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB, Meyer OW, Theiler R, Dick W, Willett WC, Egli A. Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med. 2016 Feb;176(2):175-83. doi: 10.1001/jamainternmed.2015.7148.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Calcifediol	Unknown	300 ug	Oral
Subject	Cholecalciferol	Other / unclassified	24000 iu	Oral

Indications

No indication recorded.