Esophageal Hypersensitivity Study in Patients With Gastroesophageal Reflux Disease (GERD)

Summary

The purpose of the study is to compare sensitivity of visceral pain in the esophagus using different pain stimuli.

Timeline

Start

2009-11

Primary completion

2011-01

Completion

2011-01

Outcome

Missed primary endpoint

paper CONCLUSIONS: AZD1386 had no analgesic effect on experimental esophageal pain in patients with NERD and a partial PPI response PMID 23320520 ↗

Publications

• Krarup AL, Ny L, Gunnarsson J, Hvid-Jensen F, Zetterstrand S, Simren M, Funch-Jensen P, Hansen MB, Drewes AM. Randomized clinical trial: inhibition of the TRPV1 system in patients with nonerosive gastroesophageal reflux disease and a partial response to PPI treatment is not associated with analgesia to esophageal experimental pain. Scand J Gastroenterol. 2013 Mar;48(3):274-84. doi: 10.3109/00365521.2012.758769. Epub 2013 Jan 16.

Drugs

Indications