drugset / Trial / NCT01022138

Laboratory-Treated T Cells After Second-Line Chemotherapy in Treating Patients With HER2/Neu-Negative Metastatic Breast Cancer

NCT01022138

NaSingle-groupOpen-labelTreatment

Summary

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Treating a patient's T cells in the laboratory may help the T cells kill more tumor cells when they are put back in the body. Giving laboratory-treated T cells after chemotherapy may be an effective treatment for breast cancer. PURPOSE: This phase II trial is studying how well giving laboratory-treated T cells after second-line chemotherapy works in treating patients with HER2/neu-negative metastatic breast cancer.

Timeline

Start
2010-03-08
Primary completion
2015-11-06
Completion
2019-02-19

Drugs

EvaluationDrugModalityDoseRoute
Subject HER2Bi-Armed Activated T Cells Cell therapy Intravenous
Background Cyclophosphamide Other / unclassified 1000 mg/m2

Indications