drugset / Trial / NCT01038167
A Study to Examine the Effects of Telaprevir on the Pharmacokinetics of Cyclosporine and Tacrolimus in Healthy Adults
Phase 1
Completed
20 enrolled
Vertex Pharmaceuticals Incorporated
Tibotec Pharmaceutical Limited · collab
Non-randomizedParallel-groupOpen-labelBasic science
Summary
The purpose of this study is to evaluate the effect that telaprevir has on the pharmacokinetics of cyclosporine and tacrolimus. Pharmacokinetics means how the drug is absorbed into the bloodstream, distributed in the body and eliminated from the body.
Timeline
- Start
- 2010-01
- Primary completion
- 2010-04
- Completion
- 2010-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cyclosporine | Peptide | 10 mg | Oral |
| Subject | Cyclosporine | Peptide | 100 mg | Oral |
| Subject | Tacrolimus | Small molecule | 0.5 mg | Oral |
| Subject | Tacrolimus | Small molecule | 2 mg | Oral |
| Subject | Telaprevir | Small molecule | 750 mg | Oral |