Comparison of Different Propofol Formulations

Phase 4 Completed 212 enrolled Hopital Foch

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The objective of this study is to evaluate the influence of different propofol formulations(plain or with lidocaine)on anesthetic induction. Propofol plain or with lidocaine is administered using a closed-loop algorithm in order to reach a Bispectral Index target of 50.

Timeline

Start: 2009-12
Primary completion: 2011-07
Completion: 2011-07

Publications

Background Liu N, Chazot T, Genty A, Landais A, Restoux A, McGee K, Laloe PA, Trillat B, Barvais L, Fischler M. Titration of propofol for anesthetic induction and maintenance guided by the bispectral index: closed-loop versus manual control: a prospective, randomized, multicenter study. Anesthesiology. 2006 Apr;104(4):686-95. doi: 10.1097/00000542-200604000-00012.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lidocaine	Other / unclassified	5 ml	—
Comparator	Propofol	Small molecule	45 ml	—

Indications

No indication recorded.