drugset / Trial / NCT01052194

A 12-week Study of 4 Doses of VX-509 in Subjects With Active Rheumatoid Arthritis

NCT01052194

Phase 2 Completed 206 enrolled Vertex Pharmaceuticals Incorporated
RandomizedParallel-groupDouble-blindTreatment

Summary

This study is designed to evaluate safety and assess initial efficacy of VX-509, a JAK3 inhibitor, for treatment of subjects with active RA. This study will assess the clinical response of 4 doses of VX-509 compared to placebo when administered for 12 weeks to patients with active RA. The study will also evaluate the safety and tolerability of VX-509 compared to placebo when administered for 12 weeks to subjects with active RA.

Timeline

Start
2010-02
Primary completion
2011-07
Completion
2011-07

Drugs

EvaluationDrugModalityDoseRoute
Subject decernotinib Small molecule 25 mg
Subject decernotinib Small molecule 50 mg
Subject decernotinib Small molecule 100 mg
Subject decernotinib Small molecule 150 mg

Indications