Composite Variability Index Versus Bispectral Index (BIS)

Completed 140 enrolled University Medical Center Groningen

RandomizedSingle-groupOpen-labelDiagnostic

Summary

The aim of this study is to compare the accuracy of the changes in CVI in response to a standardized noxious stimulus during various targeted pseudo-steady-state concentrations of remifentanil and various steady state level of BIS as guided by propofol effect compartment controlled TCI (closed-loop).

Timeline

Start: 2009-09
Primary completion: 2010-09
Completion: 2010-09

Publications

Sahinovic MM, Eleveld DJ, Kalmar AF, Heeremans EH, De Smet T, Seshagiri CV, Absalom AR, Vereecke HEM, Struys MMRF. Accuracy of the composite variability index as a measure of the balance between nociception and antinociception during anesthesia. Anesth Analg. 2014 Aug;119(2):288-301. doi: 10.1213/ANE.0000000000000274.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Propofol	Small molecule	—	—
Comparator	Remifentanil	Small molecule	0 ng/ml	—
Comparator	Remifentanil	Small molecule	2 ng/ml	—
Comparator	Remifentanil	Small molecule	4 ng/ml	—
Comparator	Remifentanil	Small molecule	6 ng/ml	—

Indications

No indication recorded.