Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability

Summary

This is a pilot study funded by the National Institutes of Health. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on muscle strength and physical function in older individuals. We propose to test a new method that may enable simultaneous determination of both vascular and skeletal muscle NO production for the first time in humans. Further, we will determine whether augmentation of NO-mediated responses, by administration of sildenafil citrate (Viagra), reduces fatigue and fatigability in older individuals.

Timeline

Start

2010-01

Primary completion

2013-07

Completion

2013-07

Outcome

Met primary endpoint

registry analysis (superiority or other test); Placebo Sildenafil Young vs Sildenafil Young; p = 0.02; t-test, 2 sided NCT01059994 ↗

Drugs

Indications

No indication recorded.