drugset / Trial / NCT01062451
An ACE Inhibitor (Perindopril) or an Angiotensin Receptor Blocker (Candesartan) as a Treatment for Methamphetamine Dependence
Phase 1
Completed
80 enrolled
Baylor College of Medicine
National Institute on Drug Abuse (NIDA) · collab
RandomizedParallel-groupQuadruple-blindOther
Summary
The primary objective is to determine the dose dependent effects of treatment with perindopril on methamphetamine (MA)-induced craving and on the reinforcing effects of MA indexed by MA self-administration. We will also determine the effects of treatment with candesartan on MA-induced craving and on the reinforcing effects of MA indexed by MA self-administration.
Timeline
- Start
- 2009-05
- Primary completion
- 2013-11-20
- Completion
- 2013-11-20
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Candesartan | Unknown | 16 mg | Oral |
| Comparator | Perindopril | Small molecule | 8 mg | Oral |