Tranexamic Acid in Off-pump Coronary Surgery

Completed 231 enrolled Chinese Academy of Medical Sciences, Fuwai Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The aim of this prospective, randomized, double-blinded, placebo-controlled study was to evaluate the effects of tranexamic acid, a synthetic antifibrinolytic drug, on the postoperative bleeding and transfusion requirements in patients undergoing off-pump coronary artery bypass graphing (OPCAB) surgery.

Timeline

Start: 2009-02
Primary completion: 2009-10
Completion: 2009-12

Outcome

Met primary endpoint

registry analysis (superiority or other test); Tranexamic Acid Group vs Control Group; p <0.05; Chi-squared NCT01064167 ↗

Publications

Wang G, Xie G, Jiang T, Wang Y, Wang W, Ji H, Liu M, Chen L, Li L. Tranexamic acid reduces blood loss after off-pump coronary surgery: a prospective, randomized, double-blind, placebo-controlled study. Anesth Analg. 2012 Aug;115(2):239-43. doi: 10.1213/ANE.0b013e3182264a11. Epub 2011 Jul 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tranexamic Acid	Small molecule	400 mg	—

Indications

No indication recorded.