Pharmacokinetics of Oral Morphine and Pharmacogenomics of CYP2D6 and UGT2B7, in an Urban Pediatric Population Presenting for Elective Surgery

Phase 2/3 Completed 43 enrolled University of British Columbia

RandomizedParallel-groupOpen-labelOther

Summary

The purpose of this study is to identify and collect samples from children who have taken a single oral dose of the pain medication morphine, and to determine the genetic differences in the way children metabolize (break down in the body and how it affects them) morphine.

Timeline

Start: 2010-03
Primary completion: 2012-11
Completion: 2012-11

Publications

Velez de Mendizabal N, Jimenez-Mendez R, Cooke E, Montgomery CJ, Dawes J, Rieder MJ, Aleksa K, Koren G, Jacobo-Cabral CO, Gonzalez-Ramirez R, Castaneda-Hernandez G, Carleton BC. A Compartmental Analysis for Morphine and Its Metabolites in Young Children After a Single Oral Dose. Clin Pharmacokinet. 2015 Oct;54(10):1083-90. doi: 10.1007/s40262-015-0256-4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Morphine	Other / unclassified	0.1 mg/kg	Oral
Comparator	Morphine	Other / unclassified	0.2 mg/kg	Oral
Comparator	Morphine	Other / unclassified	0.3 mg/kg	Oral

Indications

No indication recorded.