Dexmedetomidine-propofol-remifentanil Anaesthesia and Reactivity to Noxious Stimuli

Summary

Dexmedetomidine acts at central nervous system (specifically: at locus caeruleus), providing sedative and analgesic effects. It is widely used in intensive care. Surgery-related interventions elicit arousal ('nociceptive') reactions. The effects of dexmedetomidine on the neurophysiological signs of arousal are studied in surgical patients. Brain waves, electrocardiogram, Entropy Index, Bispectral Index, and fingertip pulse waves are recorded and analyzed later on. The course of anaesthesia and surgery are recorded.

Timeline

Start

2009-11

Primary completion

2011-03

Completion

2011-03

Drugs

Indications

No indication recorded.