Thoracic Paravertebral Block for Postoperative Analgesia After Video-assisted Thoracic Surgery.

Phase 3 Completed 90 enrolled Hospices Civils de Lyon

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The use of paravertebral catheters is a recommended technique to achieve postoperative analgesia after thoracic surgery. To date there is no consensus on which drug regime (local anesthetics with or without opioid) is best. The aim of this prospective clinical trial is to determine wether the use of ropivacaine and sufentanil injected through a thoracic paravertebral catheter results in decreased acute postoperative pain compared with plain ropivacaine in patients after thoracoscopic lung surgery.

Timeline

Start: 2010-03
Primary completion: 2014-09
Completion: 2014-12

Outcome

Missed primary endpoint

paper not significantly different between groups (53.1 ± 27.2 mg in the ropivacaine + sufentanil group vs. 58.8 ± 34.3 mg in the ropivacaine group; P = 0.72). PMID 29373333 ↗

Publications

Results Bauer C, Pavlakovic I, Mercier C, Maury JM, Koffel C, Roy P, Fellahi JL. Adding sufentanil to ropivacaine in continuous thoracic paravertebral block fails to improve analgesia after video-assisted thoracic surgery: A randomised controlled trial. Eur J Anaesthesiol. 2018 Oct;35(10):766-773. doi: 10.1097/EJA.0000000000000777.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ropivacaine	Other / unclassified	2 mg/ml	Other
Subject	Sufentanil	Other / unclassified	0.25 ug/ml	Other