Estrogens Effect on Pain in Postmenopausal Women Suffering of Fibromyalgia

Terminated 29 enrolled Ostergotland County Council, Sweden

RandomizedParallel-groupQuadruple-blindBasic science

Summary

In order to evaluate the potential effects of estrogen treatment in postmenopausal women with fibromyalgia, the investigators used quantitative sensory tests before and after eight weeks of estrogen treatment as compared with placebo treatment.

Timeline

Start: 2001-08
Primary completion: 2007-10
Completion: 2007-10

Outcome

Missed primary endpoint

Stopped: “Due to ethical concerns regard to the results from the WHI study”

paper CONCLUSION: Eight weeks of transdermal oestradiol treatment does not influence perceived pain, pain thresholds or pain tolerance as compared with placebo PMID 21078629 ↗

Publications

Stening KD, Eriksson O, Henriksson KG, Brynhildsen J, Lindh-Astrand L, Berg G, Hammar M, Amandusson A, Blomqvist A. Hormonal replacement therapy does not affect self-estimated pain or experimental pain responses in post-menopausal women suffering from fibromyalgia: a double-blind, randomized, placebo-controlled trial. Rheumatology (Oxford). 2011 Mar;50(3):544-51. doi: 10.1093/rheumatology/keq348. Epub 2010 Nov 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Estradiol	Other / unclassified	50 ug	Other
Background	medroxyprogesterone acetate	Other / unclassified	10 mg	—