drugset / Trial / NCT01093131

Oral Versus Intravenous Hydration to Prevent Contrast Induced Nephropathy

NCT01093131

RandomizedFactorialOpen-labelPrevention

Summary

The increased risk for contrast-induced nephropathy (CIN) in patients with chronic kidney disease (CKD) undergoing coronary angiography (CAG) has been established. Current and historical data on CIN prevention strategies have shown wide variation with respect to the optimal type, route and timing of these therapies. We investigate the role for oral hydration and/or oral sodium bicarbonate administration compared to intravenous hydration and/or sodium bicarbonate in patients with CKD undergoing CAG.

Timeline

Start
2005-02
Primary completion
2009-09
Completion
2010-02

Drugs

EvaluationDrugModalityDoseRoute
Comparator sodium bicarbonate Diagnostic / imaging agent 1 ml Intravenous
Comparator sodium bicarbonate Diagnostic / imaging agent 1.95 g Oral