drugset / Trial / NCT01093131
Oral Versus Intravenous Hydration to Prevent Contrast Induced Nephropathy
RandomizedFactorialOpen-labelPrevention
Summary
The increased risk for contrast-induced nephropathy (CIN) in patients with chronic kidney disease (CKD) undergoing coronary angiography (CAG) has been established. Current and historical data on CIN prevention strategies have shown wide variation with respect to the optimal type, route and timing of these therapies. We investigate the role for oral hydration and/or oral sodium bicarbonate administration compared to intravenous hydration and/or sodium bicarbonate in patients with CKD undergoing CAG.
Timeline
- Start
- 2005-02
- Primary completion
- 2009-09
- Completion
- 2010-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | sodium bicarbonate | Diagnostic / imaging agent | 1 ml | Intravenous |
| Comparator | sodium bicarbonate | Diagnostic / imaging agent | 1.95 g | Oral |