drugset / Trial / NCT01097746
First-Line Treatment of Bevacizumab, Carboplatin, and Paclitaxel in Treating Participants With Stage III-IV Ovarian, Primary Peritoneal, and Fallopian Tube Cancer
NaSingle-groupOpen-labelTreatment
Summary
This phase II trial studies how well first-line treatment of bevacizumab, carboplatin, and paclitaxel work in treating participants with stage III- IV ovarian, primary peritoneal and fallopian tube cancer. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving bevacizumab, carboplatin, and paclitaxel as first-line treatment may work better at treating ovarian, primary peritoneal, and fallopian tube cancer.
Timeline
- Start
- 2010-04-14
- Primary completion
- 2021-12-07
- Completion
- 2022-09-13
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bevacizumab | Monoclonal antibody | — | Intravenous |
| Subject | Carboplatin | Small molecule | — | Intravenous |
| Subject | Paclitaxel | Small molecule | — | Intravenous |
Indications
fallopian tube clear cell adenocarcinoma
fallopian tube endometrioid adenocarcinoma
fallopian tube mucinous adenocarcinoma
fallopian tube serous adenocarcinoma
fallopian tube transitional cell carcinoma
malignant ovarian Brenner tumor
ovarian clear cell adenocarcinoma
ovarian endometrioid adenocarcinoma
ovarian mucinous adenocarcinoma
ovarian seromucinous carcinoma
ovarian serous adenocarcinoma
ovarian transitional cell carcinoma
primary peritoneal serous adenocarcinoma
undifferentiated ovarian carcinoma
uterine adnexa cancer