drugset / Trial / NCT01104844
Maxi-Analgesic Phase 2 Study to Compare the Analgesic Effects in Different Dosing Groups to Treat Teeth Extraction Pain
RandomizedParallel-groupDouble-blindTreatment
Summary
The aim of the study is to examine the dose response relationship in the treatment of dental pain (teeth extraction) for the different potential doses of the investigational drug, i.e. 2 tablets, 1 tablet or ½ a tablet given 4 times a day.
Timeline
- Start
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- Primary completion
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- Completion
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Publications
- Background Merry AF, Gibbs RD, Edwards J, Ting GS, Frampton C, Davies E, Anderson BJ. Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial. Br J Anaesth. 2010 Jan;104(1):80-8. doi: 10.1093/bja/aep338.
- Background Ong CK, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010 Apr 1;110(4):1170-9. doi: 10.1213/ANE.0b013e3181cf9281. Epub 2010 Feb 8.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetaminophen | Small molecule | 125 mg | Oral |
| Comparator | Acetaminophen | Small molecule | 250 mg | Oral |
| Comparator | Acetaminophen | Small molecule | 500 mg | Oral |
| Comparator | Ibuprofen | Small molecule | 37.5 mg | Oral |
| Comparator | Ibuprofen | Small molecule | 75 mg | Oral |
| Comparator | Ibuprofen | Small molecule | 150 mg | Oral |
| Comparator | Ibuprofen | Small molecule | 300 mg | Oral |