Neoadjuvant Treatment of Colon Cancer

Phase 2 Completed 76 enrolled Vejle Hospital Herlev Hospital · collab

Non-randomizedFactorialOpen-labelTreatment

Summary

This study will investigate * the effect of preoperative combination chemotherapy in patients with locally advanced colon cancer with mutation in the KRAS, BRAF or PIK3CA gene * the effect of preoperative combination chemotherapy in combination with biological treatment in patients without mutation in the KRAS, BRAF or PIK3CA gene.

Timeline

Start: 2010-04
Primary completion: 2013-09
Completion: 2015-03

Publications

Dam C, Lund-Rasmussen V, Ploen J, Jakobsen A, Rafaelsen SR. Computed tomography assessment of early response to neoadjuvant therapy in colon cancer. Dan Med J. 2015 Jul;62(7):A5103.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Panitumumab	Monoclonal antibody	9 mg/kg	Intravenous
Background	Capecitabine	Small molecule	2000 mg/m2	Oral
Background	Oxaliplatin	Small molecule	130 mg/m2	Intravenous

Neoadjuvant Treatment of Colon Cancer

Summary

Timeline

Publications

Drugs

Indications