Inflammatory Cytokines Profile in Individuals Subjected to Surgical Procedures Using Propofol or Isoflurane

Phase 4 Completed 40 enrolled UPECLIN HC FM Botucatu Unesp Fundação de Amparo à Pesquisa do Estado de São Paulo · collab

RandomizedParallel-groupDouble-blindSupportive care

Summary

The aim of this study is to assess the profile of cytokines IL-1beta, IL-6, IL-8, IL-10, IL-12 and TNF-alpha under inhalation anesthesia with isoflurane and intravenous anesthesia with propofol in healthy patients subjected to minimally invasive elective surgeries.

Timeline

Start: 2008-03
Primary completion: 2009-12
Completion: 2009-12

Publications

Mazoti MA, Braz MG, de Assis Golim M, Braz LG, Dias NH, Salvadori DM, Braz JR, Fecchio D. Comparison of inflammatory cytokine profiles in plasma of patients undergoing otorhinological surgery with propofol or isoflurane anesthesia. Inflamm Res. 2013 Oct;62(10):879-85. doi: 10.1007/s00011-013-0643-y. Epub 2013 Jun 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Isoflurane	Other / unclassified	1 unknown	Inhaled
Subject	Propofol	Small molecule	2 ug/ml	Intravenous
Subject	Propofol	Small molecule	4 ug/ml	Intravenous

Indications

No indication recorded.