drugset / Trial / NCT01114997
Effect of Lidocaine and Esmolol to Improve the Quality of Recovery
RandomizedFactorialQuadruple-blindPrevention
Summary
The purpose of this prospective, randomized, double-blinded, active-controlled study is: To assess the effectiveness of systemic administration of lidocaine and esmolol in combination (vs. either drug alone) will result in improved postoperative outcomes for patients undergoing abdominal surgery (e.g., less pain and postoperative constipation, nausea and vomiting, faster return of bowel function, resumption of normal activities of daily living), leading to a shorten length of hospital stay, maintaining hemodynamic stability during general anesthesia, when administered as intravenous adjuvants
Timeline
- Start
- 2010-04
- Primary completion
- 2015-06
- Completion
- 2015-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Esmolol | Other / unclassified | 7.5 ug/kg | Intravenous |
| Subject | Esmolol | Other / unclassified | 15 ug/kg | Intravenous |
| Subject | Lidocaine | Other / unclassified | 0.75 mg/kg | Intravenous |
| Subject | Lidocaine | Other / unclassified | 1.5 mg/kg | Intravenous |