drugset / Trial / NCT01114997

Effect of Lidocaine and Esmolol to Improve the Quality of Recovery

NCT01114997

Phase 4 Terminated 32 enrolled Cedars-Sinai Medical Center
RandomizedFactorialQuadruple-blindPrevention

Summary

The purpose of this prospective, randomized, double-blinded, active-controlled study is: To assess the effectiveness of systemic administration of lidocaine and esmolol in combination (vs. either drug alone) will result in improved postoperative outcomes for patients undergoing abdominal surgery (e.g., less pain and postoperative constipation, nausea and vomiting, faster return of bowel function, resumption of normal activities of daily living), leading to a shorten length of hospital stay, maintaining hemodynamic stability during general anesthesia, when administered as intravenous adjuvants

Timeline

Start
2010-04
Primary completion
2015-06
Completion
2015-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Esmolol Other / unclassified 7.5 ug/kg Intravenous
Subject Esmolol Other / unclassified 15 ug/kg Intravenous
Subject Lidocaine Other / unclassified 0.75 mg/kg Intravenous
Subject Lidocaine Other / unclassified 1.5 mg/kg Intravenous

Indications