Comparing Efficacy and Safety of Inhaled SNG001 to Placebo

Summary

When people with asthma get respiratory virus such as a cold or flu it often increases asthma symptoms. The investigators will test the study medication to find out if it can prevent the virus spreading from the nose to the lungs. SNG001 contains Interferon-beta that occurs naturally in the body. In this study, SNG001 will be given by a nebuliser.

Timeline

Start

2010-03

Primary completion

2011-10

Completion

2012-01

Outcome

Missed primary endpoint

paper IFN-β treatment had no significant effect on this primary endpoint PMID 24937476 ↗

paper Although the trial did not meet its primary endpoint PMID 24937476 ↗

Publications

• Djukanovic R, Harrison T, Johnston SL, Gabbay F, Wark P, Thomson NC, Niven R, Singh D, Reddel HK, Davies DE, Marsden R, Boxall C, Dudley S, Plagnol V, Holgate ST, Monk P; INTERCIA Study Group. The effect of inhaled IFN-beta on worsening of asthma symptoms caused by viral infections. A randomized trial. Am J Respir Crit Care Med. 2014 Jul 15;190(2):145-54. doi: 10.1164/rccm.201312-2235OC.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Interferon beta-1a	Protein / enzyme biologic	—	Inhaled

Indications