Effects of Estrogen and Hot Flashes on Mood in Postmenopausal Women

Phase 2 Terminated 2 enrolled Massachusetts General Hospital National Institutes of Health (NIH) · collab

RandomizedSingle-groupQuadruple-blindTreatment

Summary

This protocol is a controlled study of estradiol therapy in early postmenopausal women with and without frequent hot flashes that will be used to determine whether hot flashes are an important intermediary in the generation of menopause-associated depression.

Timeline

Start: 2010-05
Primary completion: 2011-02
Completion: 2011-02

Outcome

Outcome not reported

Stopped (Enrollment): “Stopped enrolling subjects due to challenge of identifying eligible participants”

Publications

Galvan T, Camuso J, Sullivan K, Kim S, White D, Redline S, Joffe H. Association of estradiol with sleep apnea in depressed perimenopausal and postmenopausal women: a preliminary study. Menopause. 2017 Jan;24(1):112-117. doi: 10.1097/GME.0000000000000737.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Estradiol	Other / unclassified	1 mg	Oral

Indications

No indication recorded.