Gabapentin Versus Transdermal Fentanyl Matrix for Chronic Neuropathic Pain

Phase 4 Completed 108 enrolled Seoul National University Hospital Asan Medical Center · collab Chonnam National University Hospital · collab Chung-Ang University Hospital · collab Dankook University · collab Inje University · collab Seoul National University Bundang Hospital · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

Gabapentin is a first line medication and fentanyl is second line medication in neuropathic pain. But, there is no head to head study on the efficacy of those medication in neuropathic pain. The hypothesis of this study is that the efficacy of the transdermal fentanyl matrix is not inferior to the gabapentin in neuropathic pain.

Timeline

Start: 2010-05
Primary completion: 2011-11
Completion: 2011-11

Outcome

Met primary endpoint

paper Analysis of the primary efficacy endpoint established the noninferiority of fentanyl matrix compared with gabapentin PMID 30863474 ↗

Publications

Hwang CJ, Lee JH, Kim JH, Min SH, Park KW, Seo HY, Song KS. Gabapentin versus Transdermal Fentanyl Matrix for the Alleviation of Chronic Neuropathic Pain of Radicular Origin: A Randomized Blind Multicentered Parallel-Group Noninferiority Trial. Pain Res Manag. 2019 Feb 4;2019:4905013. doi: 10.1155/2019/4905013. eCollection 2019.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fentanyl	Other / unclassified	100 ug	Other
Subject	Gabapentin	Unknown	2400 mg	—