drugset / Trial / NCT01140516
Effectiveness of Antibiotics Versus Placebo to Treat Antenatal Hydronephrosis
Unknown
160 enrolled
McMaster University
Hamilton Health Sciences Corporation · collabMcMaster Surgical Associates · collabThe Physicians' Services Incorporated Foundation · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
This study focuses on the relationship between prophylaxis antibiotics and frequency of urinary tract infection in children diagnosed with antenatal hydronephrosis. Hydronephrosis is the most common fetal abnormality occurring in 1-5% of all pregnancies. Currently, with the widespread accessibility of antenatal ultrasound across cities in Ontario, the detection of hydronephrosis has become even more common. As a result, thousands of infants with hydronephrosis have been seen and managed by pediatricians, pediatric nephrologists, pediatric urologists, and family physicians. The investigators need to determine if antibiotic prophylaxis is effective in reducing the number of urinary tract infections in this population.
Timeline
- Start
- 2010-07
- Primary completion
- 2024-09
- Completion
- 2024-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Trimethoprim | Small molecule | 2 mg/kg | Oral |