Trimethoprim
Small molecule targets SLC19A3 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | BACTRIM | — | 1973-07-30 | fda.gov ↗ |
Trials 42
Press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2016-03-29 | Aytu BioPharma, Inc. | Aytu BioScience Announces U.S. Co-Promotion Agreement for Primsol aytubio.com ↗ |
Evidence & citations 49 cited values
Every value below carries the sentence it was read from. 85 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Trimethoprim | “AIDS patients with TE were randomly divided into 3 groups that received a 6-week course of either pyrimethamine (50 mg/day or 100 mg/day) plus sulfadiazine (4 g/day) and...” NCT00367081 ↗81“Possible prescribed antibiotics include: trimethoprim and sulfamethoxazole (Septra), Cefalotin, Cephalexin, Cefapirin, Cefdroxil, Cefazolin, Cefradine, Cefacetrile,...” NCT03877289 ↗ “A 3-day course of oral amoxicillin (500 mg three times per day) or trimethoprim/sulfamethoxazole in penicillin-allergic patients (160 mg trimethoprim / 800mg sulfamethoxazole...” NCT01967758 ↗ “Participants will receive a single oral dose of either Bactrim (800 mg sulfamethoxazole + 160 mg trimethoprim) or if allergic to sulfonamides, a single oral dose of Macrobid...” NCT07501065 ↗ “Daily oral cotrimoxazole suspension from 1 to 6 months of age at the following weight-based doses: * less than 5kg: 100mg sulfamethoxazole, 20mg trimethoprim * greater than...” NCT01086878 ↗ “Patients randomized to the "Procedural Antibiotics Only" arm will receive a single dose of trimethoprim/sulfamethoxazole (800/160mg) peri-procedurally at the time of the first...” NCT03508921 ↗ “Oral dose regimen for simple urinary tract infection: Including cephalexin, cefdinir, sulfamethoxazole/trimethoprim, and nitrofurantoin at appropriate dose, frequency, and duration” NCT05702762 ↗ “Antimicrobials included co-trimoxazole (trimethoprim 160 mg/sulfamethoxazole 800 mg twice daily plus folic acid 5 mg daily, n = 128) or doxycycline” PMID 33974018 ↗ May 2021 “800 mg sulfamethoxazole/160 mg trimethoprim twice daily (BID) + MMX Mesalazine/mesalamine placebo once daily (QD) orally for 3 days” NCT01469637 ↗ “Sulfamethoxazole/trimethoprim (Bactrim): one double strength (DS) tablet (800 mg/160 mg) twice per day for adolescents and adults” NCT06397781 ↗ “one dose of either Trimethoprim (if \< 2 months) or Trimethoprim-Sulfamethoxazole (if ≥ 2 months) or placebo in suspension.” NCT05438082 ↗ |
| Known as | BW 56-72 | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | BW 72U | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Infectotrimet | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Ledatrim | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Monotrim | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | NIH-204 | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | NSC-106568 | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Polymyxin/Trimethoprim | ClinicalTrials.gov intervention name — accepted as the source's own label NCT05331664 ↗ |
| Known as | Primsol | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Proloprim | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Proloprin | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Syraprim | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | TCMDC-125538 | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Tiempe | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | TMP | “sulfamethoxazole/trimethoprim (SMX/TMP)” NCT00000640 ↗1“TMP/SMZ(trimethoprim/sulfisoxazole)” NCT03978559 ↗ |
| Known as | TMP/SMZ | “Trimethoprim/sulfamethoxazole (TMP/SMZ)” NCT01631617 ↗ |
| Known as | Trimethoprim component of bactrim | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim component of bactrim ds | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim component of bactrim pediatric | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim component of co-trimoxazole | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim component of cotrim | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim component of cotrim d.s. | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim component of septra | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim component of sulfamethoprim | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim component of sulfatrim | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim component of sulmeprim | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim component of uroplus | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | TRIMETHOPRIM HYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | TRIMETHOPRIM MALEIC ACID SALT | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | TRIMETHOPRIM OXALIC ACID SALT DIHYDRATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | TRIMETHOPRIM SULFATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim sulfate component of polytrim | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim sulphate | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprim/sulfamethoxazole (TMP/SMZ) | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01631617 ↗ |
| Known as | Trimethoprime | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimethoprimum | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimetoprima | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimogal | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimopan | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimpex | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Trimpex 200 | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Triprimix 200 | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Known as | Wellcoprim | ChEMBL registry synonym — accepted as the source's own label CHEMBL22 ↗ |
| Action | Inhibit | “trimethoprim, have been shown to interrupt function of the SLC19A3 gene” NCT03746106 ↗ |
| Modality | Small molecule | — CHEMBL22 ↗ |
| Route | Oral | “two oral treatments for mild to moderate Pneumocystis carinii pneumonia (PCP): dapsone/trimethoprim or clindamycin/primaquine as compared to a standard treatment program of...” NCT00000640 ↗ |
| Target | SLC19A3 | “Certain drugs, like metformin and trimethoprim, have been shown to interrupt function of the SLC19A3 gene.” NCT03746106 ↗ |