drugset
drugset / Trial / NCT05398679

Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis

NCT05398679 ↗

Phase 4 Recruiting 360 enrolled Fundacion Clinic per a la Recerca Biomédica
RandomizedParallel-groupOpen-labelTreatment

Summary

Non-inferiority trial to determine whether partial oral treatment is non-inferior to OPAT(Outpatient parenteral therapy) in patients diagnosed with infective endocarditis

Timeline

Start
2022-08-17
Primary completion
2026-12-30
Completion
2027-12-30

Publications

Drugs

EvaluationDrugModalityDoseRoute
Subject Amoxicillin Other / unclassified 1 g Oral
Comparator CEFACLOR ANHYDROUS Small molecule 2 g Intravenous
Subject Ciprofloxacin Small molecule 500 mg Oral
Subject Ciprofloxacin Small molecule 750 mg Oral
Subject Ciprofloxacin Small molecule 1200 mg Oral
Subject Clindamycin Unknown 600 mg Oral
Subject Dicloxacillin Small molecule 1 g Oral
Subject Fusidic Acid Unknown 0.75 g Oral
Subject Levofloxacin Small molecule 0.5 g Oral
Subject Linezolid Other / unclassified 0.6 g Oral
Subject Moxifloxacin Small molecule 0.4 g Oral
Subject Rifampin Small molecule 0.3 g Oral
Subject Rifampin Small molecule 0.5 g Oral
Subject Rifampin Small molecule 0.6 g Oral
Subject Sulfamethoxazole Small molecule 1600 mg Oral
Subject Tedizolid Small molecule 200 mg Oral
Subject Trimethoprim Small molecule 320 mg Oral

Indications

infective endocarditis