Drugs / Sulfamethoxazole
last change Jul 2026 re-read 8 days ago

Sulfamethoxazole

Small molecule

Developed for
HIV infectious disease · pneumocystosis · bacterial infectious disease · urinary tract infection · cystic fibrosis · malaria · methicillin-resistant staphylococcus aureus infectious disease · atopic eczema
+18 more · cerebral toxoplasmosis · chronic obstructive pulmonary disease · hypotonia-cystinuria syndrome · idiopathic pulmonary fibrosis · infectious disease · infective endocarditis · osteomyelitis · Pneumocystis infectious disease · pyelonephritis · renal fibrosis · ulcer of lower limbs · abscess · bacterial urinary tract infection · periprosthetic joint infection · pneumonia · pregnancy disorder · prostatitis · vesicoureteral reflux
Investigated by
National Institute of Allergy and Infectious Diseases (NIAID) · Glaxo Wellcome · Jacobus Pharmaceutical · University of Texas Southwestern Medical Center · University of Washington · Cook Children's Medical Center
+82 more · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · St. Louis Children's Hospital · University of Michigan · University of North Carolina, Chapel Hill · Affiliated Hospital of Jiaxing University · Anhui Provincial Hospital · Baylor College of Medicine · Boston Children's Hospital · CF Therapeutics Development Network Coordinating Center · Central Hospital, Nancy, France · Chiang Mai University · Children's Hospital Medical Center, Cincinnati · Department of Medical Services Ministry of Public Health of Thailand · Duke Clinical Research Institute · Eastern Cooperative Oncology Group · FIlière des Maladies rares Abdomino-THOraciques · First Affiliated Hospital of Wenzhou Medical University · First Affiliated Hospital of Zhejiang University · Fogarty International Center of the National Institute of Health · Fresenius Kabi · Fundacion Clinic per a la Recerca Biomédica · Gary Morrow · Harvard Initiative for Global Health · Harvard School of Public Health (HSPH) · Huzhou Central Hospital · IRCCS Burlo Garofolo · Indiana University · KU Leuven · Ministry of Health, Benin · Monash University · National Cancer Institute (NCI) · National Center for Research Resources (NCRR) · National Council of Science and Technology, Mexico · National Heart, Lung, and Blood Institute (NHLBI) · National Institute of Medical Sciences and Nutrition Salvador Zubiran · National University Hospital, Cotonou · Omri Schwarztuch Gildor · Pfizer · Prothya Biosolutions · Red Cross Hospital, Hangzhou, China · Research Institute for Development · Saint Antoine University Hospital · Seattle Children's Hospital · Second Affiliated Hospital of Nanchang University · Second Affiliated Hospital, School of Medicine, Zhejiang University · Shanghai Pulmonary Hospital, Shanghai, China · Shanghai Tongji Hospital, Tongji University School of Medicine · Shaoxing People's Hospital · Shire · Sidaction · Sir Run Run Shaw Hospital · Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction · Société Francophone Nutrition Clinique et Métabolisme · Taizhou Hospital · Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University · Texas Tech University Health Sciences Center · The Allergan Foundation · The American Society of Tropical Medicine and Hygiene · The Fifth Affiliated Hospital of Wenzhou Medical University & Lishui Central Hospital · The First Affiliated Hospital of Anhui Medical University · The First Affiliated Hospital of Guangzhou Medical University · The Second Hospital of Anhui Medical University · The Sixth Affiliated Hospital of Wenzhou Medical University · Tongji Hospital · U.S. Bioscience · Universidad Complutense de Madrid · University Hospital Brussels · University of Alabama at Birmingham · University of California, San Francisco · University of Chicago · University of Colorado, Denver · University of Florida · University of Miami · University of Pittsburgh · all 88 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) GANTANOL — 1965-07-01 fda.gov ↗

Trials 35

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials · 1 met primary
Phase 1 NCT05302531 Dec 2022 → Dec 2024 overdue bacterial infectious disease, short bowel syndrome Central Hospital, Nancy, France Recruiting No outcome recorded
Phase 1 NCT01469637 Nov → Dec 2011 — Shire Completed Met primary
Phase 1 NCT00002120 — HIV infectious disease, pneumocystosis U.S. Bioscience Completed No outcome recorded
Phase 24 trials · 1 met primary
Phase 2 NCT03489629 Apr 2018 → Sep 2025 cystic fibrosis University of North Carolina, Chapel Hill Completed No outcome recorded
Phase 2 NCT02640443 Oct 2015 → Oct 2016 hypotonia-cystinuria syndrome University Hospital Brussels Unknown No outcome recorded
Phase 2 NCT01349192 Apr 2011 → Jan 2015 cystic fibrosis, methicillin-resistant staphylococcus aureus infectious disease University of North Carolina, Chapel Hill Terminated Met primary Stop: Enrollment
Phase 2 NCT00000811 ? → Nov 2001 HIV infectious disease, bacterial infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT07202078 May 2025 → Mar 2027 expected leukemia, non-Hodgkin lymphoma, plasma cell myeloma Monash University Recruiting No outcome recorded
Phase 310 trials · 1 missed
Phase 3 NCT02759120 Mar 2017 → Mar 2020 idiopathic pulmonary fibrosis Weill Medical College of Cornell University Terminated Missed primary
Phase 3 NCT00948896 Jun 2010 → Apr 2014 malaria University of California, San Francisco Completed Mixed
Phase 3 NCT00970879 Dec 2009 → Jul 2012 HIV infectious disease, malaria Research Institute for Development Completed No outcome recorded
Phase 3 NCT00002850 Mar 1997 → Apr 2011 bacterial infectious disease, plasma cell myeloma Gary Morrow Completed No outcome recorded
Phase 3 NCT00000748 ? → Nov 1996 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00000640 ? → Sep 1994 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00000715 ? → Sep 1991 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00001014 ? → Sep 1991 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00001013 ? → Sep 1991 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00000727 ? → Aug 1991 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 411 trials · 2 missed
Phase 4 NCT06397781 Jan 2031 → Dec 2035 expected atopic eczema Boston Children's Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07619027 Jun 2026 → Jun 2028 expected Pneumocystis infectious disease Anhui Provincial Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07501065 Jun 2026 → Jun 2028 expected female stress incontinence, urinary tract infection University of Miami Not yet recruiting No outcome recorded
Phase 4 NCT05398679 Aug 2022 → Dec 2026 expected infective endocarditis Fundacion Clinic per a la Recerca Biomédica Recruiting No outcome recorded
Phase 4 NCT03508921 Jul 2018 → Jun 2022 overactive bladder, urinary tract infection Vanderbilt University Medical Center Terminated No outcome recorded Stop: Enrollment
Phase 4 NCT03042260 Mar 2017 → Feb 2021 systemic lupus erythematosus National Institute of Medical Sciences and Nutrition Salvador Zubiran Unknown No outcome recorded
Phase 4 NCT01167452 Jul 2010 → May 2012 methicillin-resistant staphylococcus aureus infectious disease, obesity disorder, pneumocystosis, tuberculosis Texas Tech University Health Sciences Center Completed No outcome recorded
Phase 4 NCT01086878 Feb 2009 → Oct 2010 AIDS, anemia, neutropenia Harvard School of Public Health (HSPH) Completed No outcome recorded
Phase 4 NCT00522821 Nov 2007 → Jul 2014 infectious disease, selective IgG subclass deficiency Prothya Biosolutions Completed No outcome recorded
Phase 4 NCT00367081 May 2003 → Aug 2004 AIDS, cerebral toxoplasmosis Department of Medical Services Ministry of Public Health of Thailand Completed Missed primary
Phase not applicable6 trials · 1 missed
— NCT07665359 Jul 2026 → May 2029 expected chronic obstructive pulmonary disease Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded
— NCT05577273 Aug 2018 → Aug 2023 urinary tract infection Omri Schwarztuch Gildor Unknown No outcome recorded
— NCT01137903 Apr 2010 → Apr 2011 osteomyelitis, ulcer of lower limbs Universidad Complutense de Madrid Unknown Missed primary
— NCT00000734 ? → May 1990 HIV infectious disease National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
— NCT00000732 ? → May 1990 HIV infectious disease National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
— NCT00002283 — HIV infectious disease, pneumocystosis Jacobus Pharmaceutical Completed No outcome recorded
Comparator or background therapy29 trials
Phase 0 NCT02099240 Comparator Mar 2014 → Nov 2018 osteomyelitis University of Louisville Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT07228702 Background Jan 2026 → Oct 2027 expected pulmonary non-tuberculous mycobacterial infection Vancouver Coastal Health Enrolling by invitation No outcome recorded
Phase 1 NCT01967758 Background Jan 2014 → Jun 2018 anaplastic astrocytoma, brain neoplasm, glioblastoma Providence Health & Services Completed No outcome recorded
Phase 1/2 NCT01632891 Background Jan 2014 → Jun 2016 HIV infectious disease, parasitemia Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections Completed Missed primary
Phase 1/2 NCT00141037 Background Mar 2004 → Sep 2006 kidney disorder National Institute of Allergy and Infectious Diseases (NIAID) Completed Missed primary

Evidence & citations 28 cited values

Every value below carries the sentence it was read from. 65 sources stand behind the page.

FieldValueCited text
Known as Sulfamethoxazole “AIDS patients with TE were randomly divided into 3 groups that received a 6-week course of either pyrimethamine (50 mg/day or 100 mg/day) plus sulfadiazine (4 g/day) and...” NCT00367081 ↗
62

“Possible prescribed antibiotics include: trimethoprim and sulfamethoxazole (Septra), Cefalotin, Cephalexin, Cefapirin, Cefdroxil, Cefazolin, Cefradine, Cefacetrile,...” NCT03877289 ↗

“A 3-day course of oral amoxicillin (500 mg three times per day) or trimethoprim/sulfamethoxazole in penicillin-allergic patients (160 mg trimethoprim / 800mg sulfamethoxazole...” NCT01967758 ↗

“Participants will receive a single oral dose of either Bactrim (800 mg sulfamethoxazole + 160 mg trimethoprim) or if allergic to sulfonamides, a single oral dose of Macrobid...” NCT07501065 ↗

“Daily oral cotrimoxazole suspension from 1 to 6 months of age at the following weight-based doses: * less than 5kg: 100mg sulfamethoxazole, 20mg trimethoprim * greater than...” NCT01086878 ↗

“Patients randomized to the "Procedural Antibiotics Only" arm will receive a single dose of trimethoprim/sulfamethoxazole (800/160mg) peri-procedurally at the time of the first...” NCT03508921 ↗

“Oral dose regimen for simple urinary tract infection: Including cephalexin, cefdinir, sulfamethoxazole/trimethoprim, and nitrofurantoin at appropriate dose, frequency, and duration” NCT05702762 ↗

“Antimicrobials included co-trimoxazole (trimethoprim 160 mg/sulfamethoxazole 800 mg twice daily plus folic acid 5 mg daily, n = 128) or doxycycline” PMID 33974018 ↗ May 2021

“Sulfamethoxazole/trimethoprim (Bactrim): one double strength (DS) tablet (800 mg/160 mg) twice per day for adolescents and adults” NCT06397781 ↗

“sulfamethoxazole were prescribed to prevent hemorrhagic cystitis and Pneumocystis Jirovecii Pneumonia (PJP), respectively” NCT06341998 ↗

“we randomized adults to oral trimethoprim-sulfamethoxazole or placebo after uncomplicated abscess incision and drainage.” PMID 20346539 ↗ Mar 2010

Show 52 more sources

Known as Gantanol ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Gantanol-ds ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as NSC-147832 ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as RO 4-2130 ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sinomin ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as SMX “sulfamethoxazole/trimethoprim (SMX/TMP)” NCT00000640 ↗
Known as STX-608 ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole component of azo gantanol ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole component of bactrim ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole component of bactrim ds ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole component of bactrim pediatric ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole component of co-trimethoxazole ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole component of cotrim ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole component of cotrim d.s. ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole component of septra ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole component of sulfamethoprim ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole component of sulfatrim ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole component of sulmeprim ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole component of uroplus ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazole sodium ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfamethoxazolum ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as Sulfametoxazol ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗
Known as sulphamethoxazole “8 mg/kg/dose trimethoprim + 40 mg/kg/dose sulphamethoxazole” NCT00933049 ↗
Known as Suphamethoxazole ChEMBL registry synonym — accepted as the source's own label CHEMBL443 ↗