Efficacy of Surgical Treatment of Osteomyelitis in Diabetic Foot Ulcers
Summary
Hypothesis:Surgical treatment of osteomyelitis in diabetic foot is more effective that medical treatment through antibiotherapy and leads wound healing in ulcers complicated with bone infection.Material and Methods: Randomized clinical trials which include two groups of patients (n=88), one receives medical treatment through antibiotherapy during 90 days and the other group receive conservative surgical treatment and antibiotics during 7 days after surgery. It will be studied differences between both groups in healing time, recidives, present and relationship of adverse events and outflow of quality of life related health .
Timeline
- Start
- 2010-04
- Primary completion
- 2011-04
- Completion
- 2011-11
Outcome
Missed primary endpoint
paper Eighteen patients (75%) achieved primary healing in the AG, and 19 (86.3%) in the SG (P = 0.33). PMID 24130347 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amoxicillin | Other / unclassified | 875 mg | — |
| Subject | Ciprofloxacin | Small molecule | 500 mg | — |
| Subject | Clavulanate | Unknown | 125 mg | — |
| Subject | Sulfamethoxazole | Small molecule | 800 mg | — |
| Subject | Trimethoprim | Small molecule | 160 mg | — |