Dicloxacillin

also known as BRL-1702 · Dicloxacilina · DICLOXACILLIN SODIUM · Dicloxacillin sodium hydrate · Dicloxacillin sodium monohydrate · Dicloxacillin sodium salt monohydrate · Dicloxacilline · Dicloxacillinum natricum · +8 more

Small molecule

Developed for: bacterial infectious disease · endocarditis · gram-positive bacterial infections · infective endocarditis · atopic eczema · infective arthritis · osteomyelitis
Investigated by: Fundacion Clinic per a la Recerca Biomédica · Hadassah Medical Organization · Pfizer · Sara Thønnings · University of Southern Denmark · West Virginia University

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Label expansion	US (FDA)	PATHOCIL	—	1985-08-12	fda.gov ↗
Approved	US (FDA)	PATHOCIL	—	1968-04-22	fda.gov ↗

Trials 6 · a red edge is where a trial was stopped

today

US approved 1968

NCT05398679 · Ph 4 NCT05156437 · Ph 4 NCT05073627 · Ph 1 NCT03108690 · Ph 4 NCT00162474 · not/applicable NCT00037050 · Ph 3

196719681969197019711972197319741975197619771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029203020312032

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 11 trial
Phase 1	NCT05073627	Feb → Jun 2022	—	University of Southern Denmark	Completed	No outcome recorded
Phase 31 trial
Phase 3	NCT00037050	Apr 2002 → Jul 2005	gram-positive bacterial infections	Pfizer	Completed	No outcome recorded
Phase 43 trials
Phase 4	NCT05398679	Aug 2022 → Dec 2026 expected	infective endocarditis	Fundacion Clinic per a la Recerca Biomédica	Recruiting	No outcome recorded
Phase 4	NCT05156437	Mar 2022 → Oct 2024	endocarditis	West Virginia University	Terminated	No outcome recorded
Phase 4	NCT03108690	Oct 2017 → Mar 2023	bacterial infectious disease	Sara Thønnings	Withdrawn	No outcome recorded
Phase not applicable1 trial
—	NCT00162474	Sep 2003 → Dec 2030 expected	—	Hadassah Medical Organization	Recruiting	No outcome recorded

Also used as a comparator or background therapy in 4 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 01 trial
Phase 0	NCT02099240 Comparator	Mar 2014 → Nov 2018	osteomyelitis	University of Louisville	Terminated	No outcome recorded
Phase 11 trial
Phase 1	NCT02983890 Comparator	Oct 2016 → Apr 2017	—	Per Damkier	Completed	No outcome recorded
Phase 42 trials
Phase 4	NCT05578482 Comparator	Oct 2022 → May 2023	atopic eczema	Jacob Pontoppidan Thyssen	Unknown	No outcome recorded
Phase 4	NCT04563325 Comparator	Sep 2020 → Jan 2024	bacterial infectious disease, infective arthritis, osteomyelitis	Rigshospitalet, Denmark	Completed	No outcome recorded

Evidence & citations 20 cited values

Every value below carries the sentence it was read from. 11 sources stand behind the page.

Field	Value	Cited text
Known as	Dicloxacillin	“Dicloxacillin” NCT03108690 ↗ 9 “Dicloxacillin” NCT02099240 ↗ NCT00162474 ↗ NCT05156437 ↗ NCT05578482 ↗ NCT02983890 ↗ NCT05398679 ↗ NCT04563325 ↗ NCT05073627 ↗ NCT00037050 ↗
Known as	BRL-1702	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	Dicloxacilina	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	DICLOXACILLIN SODIUM	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	Dicloxacillin sodium hydrate	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	Dicloxacillin sodium monohydrate	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	Dicloxacillin sodium salt monohydrate	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	Dicloxacilline	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	Dicloxacillinum natricum	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	Dycill	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	Dynapen	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	NSC-756726	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	P-1011	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	Pathocil	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	R-13423	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	Sodium dicloxacillin	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Known as	Sodium dicloxacillin monohydrate	ChEMBL registry synonym — accepted as the source's own label CHEMBL893 ↗
Action	Activate	“Dicloxacillin also activates the PXR receptor in vitro” NCT05073627 ↗
Modality	Small molecule	— CHEMBL893 ↗
Route	Oral	“High-dose oral dicloxacillin” NCT04563325 ↗