drugset / Trial / NCT03746106
The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine
Phase 4
Completed
7 enrolled
University of California, San Francisco
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collabTufts University · collabUniversity of California, Davis · collab
RandomizedCrossoverOpen-labelBasic science
Summary
In Part 1, subjects will be administered thiamine, thiamine with metformin, and thiamine with trimethoprim. Part 2 will expand on Part 1 and subjects will be administered thiamine and thiamine with trimethoprim. The goal is to determine whether taking a drug and a vitamin together affects the body's ability to absorb, distribute, and eliminate thiamine (Vitamin B1).
Timeline
- Start
- 2019-01-28
- Primary completion
- 2023-08-10
- Completion
- 2023-08-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Metformin | Small molecule | 1000 mg | Oral |
| Subject | Trimethoprim | Small molecule | 300 mg | Oral |