drugset / Trial / NCT03173053
S. Aureus Decolonization in HPN Patients.
Terminated
63 enrolled
Radboud University Medical Center
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · collabUniversity College, London · collabZonMw: The Netherlands Organisation for Health Research and Development · collab
RandomizedParallel-groupOpen-labelPrevention
Summary
This trial focusses on identifying the most effective and safe long-term S. aureus carriage decolonization strategy in home parenteral nutrition patients. Half of the participants will receive a quick and short systemic antibiotic treatment combined with topical treatment, while the other half will receive only topical treatment on a periodic basis.
Timeline
- Start
- 2018-02-08
- Primary completion
- 2021-10-14
- Completion
- 2021-10-14
Outcome
Outcome not reported
Stopped: “Results interim-analysis”
Publications
- Gompelman M, Wezendonk GTJ, Wouters Y, Beurskens-Meijerink J, Fragkos KC, Rahman FZ, Coolen JPM, van Weerdenburg IJM, Wertheim HFL, Kievit W, Akkermans RP, Serlie MJ, Bleeker-Rovers CP, Wanten GJA. Randomized clinical trial: Long-term Staphylococcus aureus decolonization in patients on home parenteral nutrition. Clin Nutr. 2023 May;42(5):706-716. doi: 10.1016/j.clnu.2023.03.010. Epub 2023 Mar 17.
- Gompelman M, Wouters Y, Kievit W, Hopman J, Wertheim HF, Bleeker-Rovers CP, Wanten GJA. Long-term Staphylococcus aureus decolonization in patients on home parenteral nutrition: study protocol for a randomized multicenter trial. Trials. 2018 Jun 28;19(1):346. doi: 10.1186/s13063-018-2732-2.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Chlorhexidine | Small molecule | 2 mg/ml | Topical |
| Comparator | Chlorhexidine | Small molecule | 40 mg/ml | Topical |
| Comparator | Ciprofloxacin | Small molecule | 750 mg | — |
| Comparator | Clarithromycin | Small molecule | 500 mg | — |
| Comparator | Clindamycin | Unknown | 600 mg | — |
| Comparator | Doxycycline | Small molecule | 200 mg | — |
| Comparator | Fusidic Acid | Unknown | 500 mg | Topical |
| Comparator | Mupirocin | Small molecule | — | Intranasal |
| Comparator | Povidone-Iodine | Other / unclassified | 75 mg/ml | Topical |
| Comparator | Rifampicin | Small molecule | 600 mg | — |
| Comparator | Sulfamethoxazole/trimethoprim | Unknown | 960 mg | — |
| Comparator | Trimethoprim | Small molecule | 200 mg | — |