drugset

drugset / Trial / NCT01148043

Pharmacological Treatment In Osteoarthritis

NCT01148043 ↗

Phase 3 Completed 200 enrolled Maasstad Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to determine the efficacy of hydroxychloroquine in hand osteoarthritis.

Timeline

Start: 2010-07
Primary completion: 2014-06
Completion: 2014-09

Outcome

Missed primary endpoint

paper At 24 weeks, change in pain VAS was not significantly different between both groups PMID 29125901 ↗

paper CONCLUSION: Treatment with HCQ at 24 weeks is not effective in reducing the symptoms of hand OA compared to placebo. PMID 29125901 ↗

Publications

Lee W, Ruijgrok L, Boxma-de Klerk B, Kok MR, Kloppenburg M, Gerards A, Huisman M, Hazes M, de Sonnaville P, Grillet B, Weel A, Basoski N. Efficacy of Hydroxychloroquine in Hand Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial. Arthritis Care Res (Hoboken). 2018 Sep;70(9):1320-1325. doi: 10.1002/acr.23471. Epub 2018 Aug 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydroxychloroquine	Small molecule	400 mg	—

Indications