Aliskiren Combined With Losartan in Proteinuric, Non-diabetic Chronic Kidney Disease

Summary

Study objective: To investigate the potential anti-proteinuric and renoprotective efficacy of aliskiren in addition to losartan in patients at risk of developing end-stage renal disease (ESRD) Methods: This will be a randomized, double-blind study in which proteinuric, non-diabetic patients with chronic kidney disease (CKD) will be assigned in a 1:1 ratio to one of the following treatment groups for 3 years: * Group A: Losartan (Control arm: conventional treatment)\* * Group B: Aliskiren plus Losartan (Intervention arm)\* * With optional addition of other anti-hypertensive agents to achieve an optimal target blood pressure of \<130/80 mmHg.

Timeline

Start

2009-07

Primary completion

2014-08

Completion

2014-08

Drugs

Indications