Effect of Losartan in Patients With Nonobstructive Hypertrophic Cardiomyopathy

Summary

The purpose of this study is to determine whether taking losartan helps people with hypertrophic nonobstructive cardiomyopathy feel better by decreasing the amount of heart muscle thickening and/or the amount of heart muscle scarring.

Timeline

Start

2007-02

Primary completion

2010-07

Completion

2010-07

Outcome

Met primary endpoint

registry analysis (superiority or other test); Losartan 50 mg PO BID vs Placebo; p = 0.02; Wilcoxon (Mann-Whitney) NCT01150461 ↗

Publications

• Shimada YJ, Passeri JJ, Baggish AL, O'Callaghan C, Lowry PA, Yannekis G, Abbara S, Ghoshhajra BB, Rothman RD, Ho CY, Januzzi JL, Seidman CE, Fifer MA. Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy. JACC Heart Fail. 2013 Dec;1(6):480-7. doi: 10.1016/j.jchf.2013.09.001. Epub 2013 Oct 24.

Drugs

Indications