RAD001 in Pheochromocytoma or Nonfunctioning Carcinoid

Summary

* According to Martin F et al, AKT is highly phosphorylated in phenochromocytoma but not in benign adrenocortical tumors. * In nonfunctioning carcinoid, the PI3K/AKT/mTOR pathway is activated. * Although mTOR is clearly an attractive therapeutic target in tumor, no clinical study on mTOR inhibition by RAD001 have been conducted in pheochromocytoma or extra-adrenal paraganglioma or non-functioning carcinoid. * So we design this phase II study of RAD001 in pheochromocytoma or extra-adrenal paraganglioma or non-functioning carcinoid to evaluate the efficacy of RAD001 in this orphan disease.

Timeline

Start

2008-07

Primary completion

2011-05

Completion

2011-12

Drugs

Indications