Drugs / Everolimus
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Everolimus

also known as RAD-001 · Certican · Afinitor · EVR · EVE · Zortress · RAD001 (Everolimus) · EVL · +10 more

Small molecule targets HIF1A, MTOR via inhibition

Developed for
breast cancer · renal cell carcinoma · cancer · non-small cell lung carcinoma · disease related to solid organ transplantation · head and neck cancer · neuroendocrine neoplasm · tuberous sclerosis
+304 more · clear cell renal carcinoma · estrogen-receptor positive breast cancer · prostate cancer · colorectal cancer · female breast carcinoma · hormone receptor-positive breast cancer · kidney cancer · metastatic malignant neoplasm · pancreatic neuroendocrine tumor · cancer of unknown primary site · gastric cancer · triple-negative breast carcinoma · endometrial cancer · hepatocellular carcinoma · Her2-receptor negative breast cancer · carcinoid tumor · cytomegalovirus infection · diffuse large B-cell lymphoma · metastatic neoplasm · neuroendocrine carcinoma · plasma cell myeloma · transplant rejection · breast neoplasm · glioblastoma · lymphoma · mantle cell lymphoma · HER2 positive breast carcinoma · Hodgkins lymphoma · lung cancer · ovarian cancer · refractory malignant neoplasm · acute myeloid leukemia · B-cell chronic lymphocytic leukemia · central nervous system neoplasm · chronic renal failure syndrome · digestive system neuroendocrine neoplasm · leukemia · acute lymphoblastic leukemia · brain neoplasm · cholangiocarcinoma · diffuse intrinsic pontine glioma · digestive system cancer · epilepsy · gallbladder cancer · gastrin-producing neuroendocrine tumor · glucagonoma · kidney failure · malignant pancreatic neoplasm · neoplasm · NF2-related schwannomatosis · pancreatic endocrine carcinoma · pancreatic insulinoma · PPoma · soft tissue sarcoma · somatostatinoma · thyroid cancer · urinary bladder cancer · Waldenstrom macroglobulinemia · adenoid cystic carcinoma · anaplastic astrocytoma · angioimmunoblastic T-cell lymphoma · autosomal dominant polycystic kidney disease · chronic lymphocytic leukemia/small lymphocytic lymphoma · chronic transplant rejection · cutaneous melanoma · esophageal cancer · graft versus host disease · impaired renal function disease · liver cancer · lung neuroendocrine neoplasm · lymphangioleiomyomatosis · medullary thyroid gland carcinoma · meningioma · metastatic melanoma · myelodysplastic syndrome · pancreatic adenocarcinoma · post-transplant lymphoproliferative disease · primary peritoneal carcinoma · sarcoma · small cell lung carcinoma · subependymal giant cell astrocytoma · adult T-cell leukemia/lymphoma · anaplastic large cell lymphoma · autism · Burkitt lymphoma · carcinoma · castration-resistant prostate carcinoma · central nervous system cancer · childhood ependymoma · chronic graft versus host disease · classic Hodgkin lymphoma · colorectal adenocarcinoma · colorectal carcinoma · cutaneous neuroendocrine carcinoma · endometrial carcinoma · endometrial endometrioid adenocarcinoma · extranodal nasal NK/T cell lymphoma · fallopian tube cancer · fallopian tube carcinoma · gastroesophageal cancer · gastrointestinal stromal tumor · head and neck squamous cell carcinoma · hepatitis C virus infection · hepatosplenic T-cell lymphoma · hypopharynx squamous cell carcinoma · immunodeficiency disease · invasive breast carcinoma · kidney angiomyolipoma · kidney disorder · larynx verrucous carcinoma · MALT lymphoma · melanoma · mycosis fungoides and variants · nasal cavity and paranasal sinus squamous cell carcinoma · neurofibromatosis type 1 · nodal marginal zone B-cell lymphoma · non-Hodgkin lymphoma · oropharynx squamous cell carcinoma · osteoporosis · paraganglioma · peripheral T-cell lymphoma, not otherwise specified · Peutz-Jeghers syndrome · pheochromocytoma · plasma cell neoplasm · plexiform neurofibroma · primary cutaneous T-cell lymphoma · progesterone-receptor positive breast cancer · splenic marginal zone lymphoma · tongue cancer · transitional cell carcinoma · urothelial carcinoma · vascular malformation · verrucous carcinoma of oral cavity · acoustic neuroma · acute graft versus host disease · acute hepatitis C virus infection · acute leukemia of ambiguous lineage · adult glioblastoma · adult hepatocellular carcinoma · adult oligodendroglioma · age-related macular degeneration · ALK-negative anaplastic large cell lymphoma · anaplastic oligodendroglioma · angiolipoma · angiomyolipoma · anti-HLA hyperimmunization · arteriovenous hemangioma/malformation · astrocytoma (excluding glioblastoma) · atypical endometrial hyperplasia · atypical teratoid rhabdoid tumor · B-cell adult acute lymphocytic leukemia · B-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical Hodgkin lymphoma · Birt-Hogg-Dube syndrome · BK-virus nephropathy · bone cancer · bone sarcoma · brain cancer · brain glioma · brain oligodendroglioma · breast carcinoma · carcinoid syndrome · carcinoma of lip · cervical cancer · cervical squamous cell carcinoma · childhood acute myeloid leukemia · childhood low-grade glioma · childhood malignant neoplasm · chondrosarcoma · choroidal neovascularization · chronic kidney disease · chronic myeloid leukemia · cirrhosis of liver · combined thymoma · coronary restenosis · differentiated thyroid carcinoma · diffuse astrocytoma · diffuse gastric adenocarcinoma · diffuse midline glioma, H3 K27M-mutant · disease related to hematopoietic stem cell transplant · end stage renal failure · Epstein-Barr virus-related tumor · esophageal adenocarcinoma · esthesioneuroblastoma · extrahepatic bile duct carcinoma · fibrolamellar hepatocellular carcinoma · follicular lymphoma · gastric intestinal type adenocarcinoma · gastric neoplasm · gastroesophageal junction adenocarcinoma · germ cell tumor · glioma · gliosarcoma · grade II glioma · grade III glioma · hemangioendothelioma · high grade astrocytic tumor · high grade malignant neoplasm · HIV infectious disease · hormone-resistant prostate carcinoma · Hutchinson-Gilford progeria syndrome · idiopathic subglottic stenosis · immunodeficiency-related disorder · intracranial meningioma · inverted papilloma · isolated focal cortical dysplasia · isolated focal cortical dysplasia type II · Kaposi's sarcoma · kidney neoplasm · large cell carcinoma · liver and intrahepatic bile duct neoplasm · liver disorder · liver failure · low grade glioma · low-grade astrocytoma · lung carcinoid tumor · lymphangioma · lymphoblastic lymphoma · lymphoepithelial-like carcinoma · lymphoproliferative syndrome · male breast carcinoma · malignant epithelial tumor of ovary · malignant germ cell tumor · malignant glioma · malignant mesothelioma · malignant peripheral nerve sheath tumor · malignant pleural mesothelioma · marginal zone lymphoma · medulloblastoma · metastatic malignant neoplasm in the brain · metastatic malignant neoplasm in the colon · metastatic prostate carcinoma · metastatic squamous cell carcinoma · myelofibrosis · myeloid leukemia · myocardial infarction · nasal cavity and paranasal sinus lethal midline granuloma · nasopharyngeal squamous cell carcinoma · non-functioning endocrine neoplasm · non-neoplastic nevus · oligoastrocytoma · oligodendroglioma · oral cavity mucoepidermoid carcinoma · osteosarcoma · ovarian carcinoma · ovarian endometrioid adenocarcinoma · ovarian germ cell tumor · ovarian seromucinous carcinoma · ovarian serous cystadenocarcinoma · ovarian serous surface papillary adenocarcinoma · overgrowth syndrome · pancreatic acinar cell carcinoma · pancreatic ductal adenocarcinoma · pancreatic gastrinoma · pancreatic neuroendocrine neoplasm · pancreatic neuroendocrine tumor G1 · papillary renal cell carcinoma · peripheral arterial disease · peritoneum cancer · poisoning · polyomavirus infectious disease · premature aging syndrome · primary aldosteronism · primary central nervous system lymphoma · primary cutaneous T-cell non-Hodgkin lymphoma · PTEN hamartoma tumor syndrome · renal carcinoma · renal cell adenocarcinoma · renal fibrosis · renal pelvis carcinoma · respiratory tract infectious disorder · rhabdomyosarcoma · Richter transformation · salivary gland cancer · salivary gland disorder · salivary gland squamous cell carcinoma · secondary malignant neoplasm · skin cancer · Sturge-Weber syndrome · synovial sarcoma · systemic mastocytosis · T-cell adult acute lymphocytic leukemia · T-lymphoblastic lymphoma · testicular cancer · thyroid gland carcinoma · thyroid Hurthle cell carcinoma · tuberculosis · undifferentiated carcinoma of nasopharynx · undifferentiated ovarian carcinoma · ureter cancer · uterine cancer · uterine corpus cancer · uterine corpus sarcoma · uveal melanoma · uveitis · vascular neoplasm · venous hemangioma · vestibulocochlear nerve neoplasm · VIPoma · viral infectious disease · acute coronary syndrome · digestive system neuroendocrine tumor, grade 1/2 · disease related to transplantation · thymus neoplasm · urinary bladder carcinoma
Investigated by
Novartis Pharmaceuticals · Novartis · National Cancer Institute (NCI) · M.D. Anderson Cancer Center · Dana-Farber Cancer Institute · Memorial Sloan Kettering Cancer Center
+468 more · Genentech, Inc. · Beth Israel Deaconess Medical Center · Emory University · Fudan University · Massachusetts General Hospital · Mayo Clinic · Brigham and Women's Hospital · SCRI Development Innovations, LLC · Alliance for Clinical Trials in Oncology · University of California, San Francisco · Yonsei University · Asan Medical Center · Children's Hospital Medical Center, Cincinnati · Bayer · Boston Children's Hospital · Eisai Inc. · Fox Chase Cancer Center · GlaxoSmithKline · Hospices Civils de Lyon · NYU Langone Health · SWOG Cancer Research Network · Samsung Medical Center · University of Chicago · Vanderbilt-Ingram Cancer Center · Academic Medical Center - University of Amsterdam · Amgen · Amsterdam UMC, location VUmc · City of Hope Medical Center · Erasmus Medical Center · Gustave Roussy, Cancer Campus, Grand Paris · Odense University Hospital · Pfizer · Swiss Cancer Institute · UNC Lineberger Comprehensive Cancer Center · University of Utah · Abramson Cancer Center at Penn Medicine · Assistance Publique - Hôpitaux de Paris · AstraZeneca · Chong Kun Dang Pharmaceutical · Daniel George, MD · Eli Lilly and Company · GBG Forschungs GmbH · Herbert Hurwitz · Hospital do Rim e Hipertensão · Indiana University · Jonsson Comprehensive Cancer Center · Merck Sharp & Dohme LLC · Milton S. Hershey Medical Center · National Institute of Allergy and Infectious Diseases (NIAID) · National Institute on Aging (NIA) · OSI Pharmaceuticals · Peking University Cancer Hospital & Institute · Seoul National University Hospital · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Stemline Therapeutics, Inc. · Sun Yat-sen University · The Methodist Hospital Research Institute · The University of Texas Health Science Center at San Antonio · UMC Utrecht · University of California, Davis · University of Cologne · University of Michigan Rogel Cancer Center · University of Texas Southwestern Medical Center · Washington University School of Medicine · Yale University · iOMEDICO AG · AIO-Studien-gGmbH · ARCAGY/ GINECO GROUP · Aarhus University Hospital · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Centre Leon Berard · Charite University, Berlin, Germany · Chulalongkorn University · Crolll Gmbh · all 474 on the full record

Regulatory milestones approvals, filings & regulatory actions · 19 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (15) US (FDA) AFINITOR 2010-10-29 – 2021-12-30 fda.gov
Label expansions (2) US (FDA) ZORTRESS 2013-02-15 – 2016-10-12 fda.gov
Approved EU (EMA) Afinitor 2009-08-02 europa.eu
Approved US (FDA) AFINITOR 2009-03-30 fda.gov

Trials 706 · started per year

today
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EU approved 2009
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20002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 09 trials
Phase 0 NCT07095933 Jul → Dec 2026 expected epilepsy Xuanwu Hospital, Beijing Recruiting No outcome recorded
Phase 0 NCT06658093 Mar 2026 → Jul 2028 expected The University of Texas Health Science Center at San Antonio Recruiting No outcome recorded
Phase 0 NCT05432518 Jun 2023 → Jul 2027 expected adult glioblastoma AHS Cancer Control Alberta Recruiting No outcome recorded
Phase 0 NCT05188118 Feb 2023 → Sep 2026 expected renal cell carcinoma Icahn School of Medicine at Mount Sinai Recruiting No outcome recorded
Phase 0 NCT05153668 Sep 2022 → Oct 2025 idiopathic subglottic stenosis Johns Hopkins University Completed No outcome recorded
Phase 0 NCT04135807 Mar 2020 → Jan 2028 expected anaplastic astrocytoma, anaplastic oligodendroglioma, brain oligodendroglioma, glioblastoma Oliver Jonas Recruiting No outcome recorded
Phase 0 NCT03834740 Jan 2019 → Feb 2022 brain glioma, glioblastoma St. Joseph's Hospital and Medical Center, Phoenix Completed No outcome recorded
Phase 0 NCT03578432 May 2018 → Nov 2019 head and neck cancer, salivary gland disorder University of Arizona Terminated No outcome recorded
Phase 0 NCT01880749 Jun 2013 → Dec 2019 NF2-related schwannomatosis, meningioma, vestibulocochlear nerve neoplasm NYU Langone Health Completed No outcome recorded
Phase 1142 trials
Phase 1 NCT07318324 May 2026 → Aug 2028 expected endometrial cancer M.D. Anderson Cancer Center Recruiting No outcome recorded
Phase 1 NCT06832189 Jan 2026 → Jun 2030 expected National Institute of Allergy and Infectious Diseases (NIAID) Recruiting No outcome recorded
Phase 1 NCT06994572 May 2025 → Apr 2029 expected hepatocellular carcinoma Captor Therapeutics S.A. Not yet recruiting No outcome recorded
Phase 1 NCT05949658 May 2024 → Mar 2027 expected University of Wisconsin, Madison Recruiting No outcome recorded
Phase 1 NCT05508906 Aug 2022 → Dec 2027 expected Her2-receptor negative breast cancer, estrogen-receptor positive breast cancer, female breast carcinoma, metastatic malignant neoplasm Olema Pharmaceuticals, Inc. Recruiting No outcome recorded
Phase 1 NCT05293964 May 2022 → Dec 2024 overdue breast cancer Jiangsu Simcere Pharmaceutical Co., Ltd. Active not recruiting No outcome recorded
Phase 1 NCT04895748 Nov 2021 → Feb 2026 clear cell renal carcinoma Novartis Pharmaceuticals Terminated No outcome recorded
Phase 1 NCT04818632 Nov 2021 → Sep 2023 estrogen-receptor positive breast cancer AstraZeneca Completed No outcome recorded
Phase 1 NCT05490095 Jul 2021 → Jan 2022 Sovargen Completed No outcome recorded
Phase 1 NCT04485559 Dec 2020 → Dec 2027 expected grade II glioma, high grade astrocytic tumor University of California, San Francisco Recruiting No outcome recorded
Show all 142 trials opens the full record — a long page
Phase 1/283 trials
Phase 1/2 NCT07435584 Mar → Dec 2026 expected colorectal cancer Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded
Phase 1/2 NCT07002177 Jun 2025 → May 2028 expected estrogen-receptor positive breast cancer Forward Pharmaceuticals Co., Ltd. Recruiting No outcome recorded
Phase 1/2 NCT06682611 Nov 2024 → Nov 2026 expected Shanghai Runshi Pharmaceutical Technology Co., Ltd Not yet recruiting No outcome recorded
Phase 1/2 NCT05563220 Jan 2023 → Dec 2026 expected breast cancer Stemline Therapeutics, Inc. Active not recruiting No outcome recorded
Phase 1/2 NCT04802759 Jun 2021 → May 2029 expected estrogen-receptor positive breast cancer Hoffmann-La Roche Recruiting No outcome recorded
Phase 1/2 NCT03697408 Feb 2019 → May 2024 overdue classic Hodgkin lymphoma University of Pennsylvania Active not recruiting No outcome recorded
Phase 1/2 NCT03805399 Oct 2018 → Dec 2022 triple-negative breast carcinoma Fudan University Unknown No outcome recorded
Phase 1/2 NCT03284957 Sep 2017 → Nov 2024 breast cancer Sanofi Terminated No outcome recorded
Phase 1/2 NCT02991807 Jun 2017 → Feb 2021 PTEN hamartoma tumor syndrome Boston Children's Hospital Completed No outcome recorded
Phase 1/2 NCT02985125 May 2017 → Jul 2019 pancreatic adenocarcinoma Georgetown University Completed No outcome recorded
Phase 2281 trials
Phase 2 NCT07634601 Dec 2026 → Dec 2028 expected endometrial carcinoma Jonsson Comprehensive Cancer Center Not yet recruiting No outcome recorded
Phase 2 NCT07522801 Sep 2026 → Dec 2029 expected Philippe ROUSSELOT Not yet recruiting No outcome recorded
Phase 2 NCT07619950 Jul 2026 → Nov 2028 expected bone cancer Yonsei University Not yet recruiting No outcome recorded
Phase 2 NCT07124078 May 2026 → Jan 2029 expected chronic graft versus host disease Incyte Corporation Recruiting No outcome recorded
Phase 2 NCT07477548 Apr 2026 → Oct 2030 expected arteriovenous hemangioma/malformation, hemangioendothelioma, lymphangioma, non-neoplastic nevus +2 Yonsei University Not yet recruiting No outcome recorded
Phase 2 NCT07340541 Feb 2026 → Jun 2031 expected estrogen-receptor positive breast cancer, triple-negative breast carcinoma UNC Lineberger Comprehensive Cancer Center Recruiting No outcome recorded
Phase 2 NCT07191353 Oct 2025 → Mar 2027 expected osteoporosis Odense University Hospital Recruiting No outcome recorded
Phase 2 NCT07037238 Jul 2025 → Jul 2026 overdue vascular malformation Xuanwu Hospital, Beijing Recruiting No outcome recorded
Phase 2 NCT06972758 Jul 2025 → Jul 2030 expected hepatocellular carcinoma Yonsei University Not yet recruiting No outcome recorded
Phase 2 NCT06730672 Dec 2024 → Dec 2027 expected renal carcinoma Sun Yat-sen University Recruiting No outcome recorded
Show all 281 trials opens the full record — a long page
Phase 2/310 trials
Phase 2/3 NCT07218575 Sep 2026 → Sep 2030 expected Bannayan-Riley-Ruvalcaba syndrome, Cowden disease, Lhermitte-Duclos disease, Martsolf syndrome +1 Boston Children's Hospital Not yet recruiting No outcome recorded
Phase 2/3 NCT03458221 Jan 2023 → Oct 2026 expected ovarian cancer Gynaecologisch Oncologisch Centrum Zuid Recruiting No outcome recorded
Phase 2/3 NCT05833815 Nov 2022 → Dec 2024 overdue gallbladder cancer Banaras Hindu University Recruiting No outcome recorded
Phase 2/3 NCT02860494 Dec 2020 → Dec 2023 vascular neoplasm Hospices Civils de Lyon Withdrawn No outcome recorded
Phase 2/3 NCT03285802 Sep 2017 → Feb 2019 uterine cancer Greater Baltimore Medical Center Completed No outcome recorded
Phase 2/3 NCT01878786 Jun 2013 → Nov 2017 Matthew Cooper Terminated No outcome recorded
Phase 2/3 NCT01730209 Nov 2012 → Nov 2015 autism, tuberous sclerosis Erasmus Medical Center Unknown No outcome recorded
Phase 2/3 NCT01023542 Jun 2011 → Jul 2014 impaired renal function disease University of Regensburg Unknown No outcome recorded
Phase 2/3 NCT01009957 Jun 2008 → Jan 2014 autosomal dominant polycystic kidney disease A. Manzoni Hospital Terminated No outcome recorded
Phase 2/3 NCT00117702 Oct 2005 → May 2008 graft versus host disease Technical University Dresden Terminated No outcome recorded
Phase 380 trials
Phase 3 NCT07407517 Feb 2026 → Feb 2033 expected female breast carcinoma, triple-negative breast carcinoma Fudan University Not yet recruiting No outcome recorded
Phase 3 NCT07239271 Nov 2025 → Dec 2027 expected HER2 positive breast carcinoma Cancer Institute and Hospital, Chinese Academy of Medical Sciences Not yet recruiting No outcome recorded
Phase 3 NCT07165418 Sep 2025 → Dec 2028 expected renal cell carcinoma Peking University Cancer Hospital & Institute Not yet recruiting No outcome recorded
Phase 3 NCT06382948 Dec 2024 → Sep 2027 expected Her2-receptor negative breast cancer, estrogen-receptor positive breast cancer MedSIR Recruiting No outcome recorded
Phase 3 NCT06680921 Nov 2024 → Aug 2028 expected breast cancer Jiangsu Simcere Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 3 NCT05954442 Sep 2023 → Aug 2025 overdue triple-negative breast carcinoma Fudan University Recruiting No outcome recorded
Phase 3 NCT05429684 Jan 2021 → Feb 2024 HER2 positive breast carcinoma First Affiliated Hospital Xi'an Jiaotong University Unknown No outcome recorded
Phase 3 NCT04258423 Dec 2019 → Jun 2020 kidney failure Indiana University Terminated No outcome recorded
Phase 3 NCT03839940 Jun 2019 → Jan 2021 cancer Alliance for Clinical Trials in Oncology Terminated No outcome recorded
Phase 3 NCT04063865 May 2019 → Jul 2020 kidney failure Indiana University Terminated No outcome recorded
Phase 474 trials
Phase 4 NCT07570433 Apr 2026 → Jan 2028 expected cytomegalovirus infection Oriol Manuel Not yet recruiting No outcome recorded
Phase 4 NCT06942156 Aug 2025 → Dec 2030 expected Chong Kun Dang Pharmaceutical Not yet recruiting No outcome recorded
Phase 4 NCT05252585 May 2023 → Oct 2026 expected kidney angiomyolipoma Novartis Pharmaceuticals Active not recruiting No outcome recorded
Phase 4 NCT04849533 Apr 2021 → Jul 2023 transplant rejection University of Cincinnati Unknown No outcome recorded
Phase 4 NCT04867720 Mar 2021 → Oct 2022 Chong Kun Dang Pharmaceutical Unknown No outcome recorded
Phase 4 NCT04471441 Jun 2020 → Jul 2024 Chong Kun Dang Pharmaceutical Completed No outcome recorded
Phase 4 NCT04177095 Feb 2020 → Sep 2021 transplant rejection Massachusetts General Hospital Completed No outcome recorded
Phase 4 NCT03797196 Jul 2019 → Jun 2025 overdue disease related to solid organ transplantation University Medical Center Groningen Active not recruiting No outcome recorded
Phase 4 NCT03525834 Nov 2018 → Sep 2020 kidney angiomyolipoma Novartis Pharmaceuticals Completed No outcome recorded
Phase 4 NCT03216967 Jan 2018 → Aug 2024 BK-virus nephropathy University Hospital, Strasbourg, France Completed No outcome recorded
Phase not applicable22 trials
NCT07144150 Apr 2026 → Sep 2028 expected peripheral arterial disease Cook Research Incorporated Recruiting No outcome recorded
NCT04199026 Feb 2025 → Dec 2028 expected sarcoma M.D. Anderson Cancer Center Recruiting No outcome recorded
NCT06317298 Feb 2024 → Aug 2025 clear cell renal carcinoma Peking University First Hospital Unknown No outcome recorded
NCT03955172 Dec 2020 → Dec 2027 expected chronic transplant rejection Hospices Civils de Lyon Recruiting No outcome recorded
NCT04906304 Jan → Jul 2020 cytomegalovirus infection Shahid Beheshti University of Medical Sciences Completed No outcome recorded
NCT02736227 Mar 2016 → Mar 2021 Northwestern University Completed No outcome recorded
NCT02551718 Sep 2015 → Jun 2020 acute leukemia of ambiguous lineage, acute lymphoblastic leukemia University of Washington Completed No outcome recorded
NCT02109913 Mar 2014 → Jan 2021 hormone receptor-positive breast cancer Amsterdam UMC, location VUmc Unknown No outcome recorded
NCT01936519 Dec 2013 → Jul 2019 immunodeficiency disease, kidney failure Milton S. Hershey Medical Center Completed No outcome recorded
NCT02013089 Dec 2013 → May 2017 digestive system cancer Sun Yat-sen University Unknown No outcome recorded
Phase not stated5 trials
NCT05108740 hormone receptor-positive breast cancer Novartis Pharmaceuticals No longer available No outcome recorded
NCT03493165 uterine corpus sarcoma The University of Texas Health Science Center at San Antonio No longer available No outcome recorded
NCT00655252 renal cell carcinoma Novartis Pharmaceuticals No longer available No outcome recorded
NCT00149981 disease related to solid organ transplantation Novartis Pharmaceuticals No longer available No outcome recorded
NCT03493152 gastrointestinal stromal tumor The University of Texas Health Science Center at San Antonio No longer available No outcome recorded
Also used as a comparator or background therapy in 116 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT02134288 Comparator Apr 2014 → Dec 2018 Ohio State University Terminated No outcome recorded
Phase 19 trials
Phase 1 NCT05501769 Background Sep 2022 → Jul 2024 breast cancer Arvinas Estrogen Receptor, Inc. Completed No outcome recorded
Phase 1 NCT05189717 Background Feb 2022 → Oct 2024 breast cancer Shandong Suncadia Medicine Co., Ltd. Unknown No outcome recorded
Phase 1 NCT02577458 Background Sep 2015 → Mar 2018 renal cell carcinoma AnewPharma Unknown No outcome recorded
Phase 1 NCT02454478 Background Jul 2015 → May 2017 renal cell carcinoma Eisai Inc. Completed No outcome recorded
Phase 1 NCT02188719 Background Dec 2014 → Jun 2019 National Institute of Allergy and Infectious Diseases (NIAID) Terminated No outcome recorded
Phase 1/217 trials
Phase 1/2 NCT06727305 Comparator May 2026 → Sep 2027 expected University of Texas Southwestern Medical Center Recruiting No outcome recorded
Phase 1/2 NCT07173556 Background Sep 2025 → Feb 2027 expected breast cancer Qilu Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 1/2 NCT05573126 Background Jan 2023 → Feb 2028 expected hormone receptor-positive breast cancer Ellipses Pharma Recruiting No outcome recorded
Phase 1/2 NCT03654040 Background Apr 2021 → Mar 2023 National Institute of Allergy and Infectious Diseases (NIAID) Terminated No outcome recorded
Phase 1/2 NCT04339062 Background Nov 2020 → Jun 2023 skin squamous cell carcinoma Dana-Farber Cancer Institute Completed No outcome recorded
Phase 233 trials
Phase 2 NCT06849947 Comparator Feb 2026 → Jun 2031 expected breast carcinoma Yeon Hee Park Not yet recruiting No outcome recorded
Phase 2 NCT06254248 Background Jan 2026 → Jan 2030 expected hepatocellular carcinoma Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Phase 2 NCT06552169 Comparator Jun 2025 → Dec 2027 expected Singulera Therapeutics Inc. Recruiting No outcome recorded
Phase 2 NCT06326190 Comparator Mar 2025 → Apr 2027 expected meningioma European Organisation for Research and Treatment of Cancer - EORTC Recruiting No outcome recorded
Phase 2 NCT06428396 Comparator Nov 2024 → May 2027 expected breast cancer Merck Sharp & Dohme LLC Active not recruiting No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT07165886 Comparator Aug 2025 → Aug 2028 expected digestive system neuroendocrine neoplasm CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Recruiting No outcome recorded
Phase 2/3 NCT06943755 Comparator Jul 2025 → Jun 2029 expected pancreatic neuroendocrine tumor Exelixis Recruiting No outcome recorded
Phase 2/3 NCT05522231 Comparator Oct 2022 → Jan 2025 overdue renal cell carcinoma Hutchmed Active not recruiting No outcome recorded
Phase 326 trials
Phase 3 NCT07062965 Comparator Aug 2025 → Jul 2027 expected breast cancer Pfizer Recruiting No outcome recorded
Phase 3 NCT07024173 Comparator Jul 2025 → Dec 2026 expected female breast carcinoma Shandong Suncadia Medicine Co., Ltd. Recruiting No outcome recorded
Phase 3 NCT06821542 Background Jun 2025 → May 2028 expected chronic graft versus host disease Incyte Corporation Active not recruiting No outcome recorded
Phase 3 NCT05918302 Comparator Oct 2023 → Mar 2029 expected lung neuroendocrine neoplasm, thymus neoplasm Spanish Group for Research in Neuroendocrine Tumors Recruiting No outcome recorded
Phase 3 NCT05476939 Comparator Sep 2022 → Sep 2028 expected diffuse midline glioma, H3 K27M-mutant Gustave Roussy, Cancer Campus, Grand Paris Recruiting No outcome recorded
Phase 419 trials
Phase 4 NCT07426484 Background Jul 2026 → Dec 2030 expected skin squamous cell carcinoma Dana-Farber Cancer Institute Not yet recruiting No outcome recorded
Phase 4 NCT04936971 Comparator Sep 2021 cytomegalovirus infection Edoardo Melilli Withdrawn No outcome recorded
Phase 4 NCT04104438 Comparator Jan 2021 → Sep 2024 Fady M Kaldas, M.D., F.A.C.S. Completed No outcome recorded
Phase 4 NCT02974686 Comparator Nov 2016 → Sep 2019 digestive system disorder, transplant rejection Washington University School of Medicine Terminated No outcome recorded
Phase 4 NCT02338609 Background Dec 2014 → Dec 2023 Novartis Pharmaceuticals Completed No outcome recorded
Phase not applicable8 trials
NCT04542733 Comparator Jun 2023 → Dec 2027 expected disease related to solid organ transplantation, polyomavirus infectious disease King Chulalongkorn Memorial Hospital Active not recruiting No outcome recorded
NCT02954198 Comparator Dec 2016 → Dec 2018 immunodeficiency disease Medical University of South Carolina Completed No outcome recorded
NCT02208583 Comparator Jun 2014 → Dec 2016 hormone-resistant prostate carcinoma Tianjin Medical University Cancer Institute and Hospital Unknown No outcome recorded
NCT02450175 Comparator Jun 2014 → Jun 2016 neoplasm Sinai Hospital of Baltimore Unknown No outcome recorded
NCT02208128 Comparator May 2014 → Feb 2018 renal cell carcinoma Heidelberg University Unknown No outcome recorded

Press releases naming this drug 10 releases

DateIssuerRelease
2017-01-31 Novartis Pharmaceuticals Novartis drug Votubia® receives EU approval to treat refractory partial-onset seizures in patients with TSC novartis.com
2016-12-16 Novartis Pharmaceuticals Novartis drug Votubia® recommended by CHMP for EU approval to treat refractory partial-onset seizures in patients with TSC novartis.com
2016-06-02 Novartis Pharmaceuticals Novartis drug Afinitor® receives EU approval to treat certain types of advanced gastrointestinal (GI) and lung neuroendocrine tumors (NET) novartis.com
2016-04-29 Novartis Pharmaceuticals Novartis drug Afinitor® recommended by CHMP for European Union approval to treat select GI and lung neuroendocrine tumors novartis.com
2016-04-20 Novartis Pharmaceuticals Novartis drug Afinitor® significantly reduces seizures in Phase III study of patients with tuberous sclerosis complex novartis.com
2016-02-26 Novartis Pharmaceuticals FDA approves new indication for Novartis drug Afinitor® for progressive, nonfunctional GI and lung neuroendocrine tumors (NET) novartis.com
2015-09-27 Novartis Pharmaceuticals Novartis drug Afinitor® significantly improves progression-free survival in advanced nonfunctional gastrointestinal and lung NET novartis.com
2015-05-29 Pfizer Pfizer’s RAPAMUNE® (sirolimus) Becomes First FDA-Approved Treatment for Lymphangioleiomyomatosis (LAM), A Rare Progressive Lung Disease pfizer.com
2015-05-21 Novartis Pharmaceuticals Novartis drug Afinitor® extended progression-free survival in Phase III trial in advanced gastrointestinal or lung neuroendocrine tumors novartis.com
2015-02-20 Pfizer FDA Accepts Supplemental New Drug Application for Priority Review of RAPAMUNE® (sirolimus) for Treatment of Lymphangioleiomyomatosis (LAM) pfizer.com

Evidence & citations 23 cited values

Every value below carries the sentence it was read from. 852 sources stand behind the page.

FieldValueCited text
Known as everolimus “The BAT in this study was identified by the investigator prior to patient randomization among the following treatments currently used in this setting: anti-thymocyte globulin...” NCT02913261
718

“The BAT in this study will freely be identified by the Investigator prior to patient randomization and may include treatments such as: anti-thymocyte globulin (ATG),...” NCT04118556

“The microdevices will dwell in the tumor tissue for a time window of 2-4 hours to allow time for tissue effects of the drugs (Temozolomide, Lomustine, Irinotecan, Carboplatin,...” NCT04135807

“A Multicentre, Randomised, Open-label, Controlled, 12-month Follow-up Study to Assess Impact on Renal Function of an Immunosuppression Regimen Based on Tacrolimus Minimisation...” NCT02040584

“We have recently demonstrated that RAD001(everolimus),an mTOR inhibitor, although with only modest growth inhibitory effects as a single agent, has significant synergistic...” NCT00632268

“Participants will receive any one of the following systemic BATs based on the Investigator's decision: mycophenolate mofetil (MMF), extracorporeal photopheresis (ECP),...” NCT04629833

“In total, 136 patients will be randomized in a 2:1 ratio to [177Lu]Lu-DOTATATE (≤4 doses of 7.4 GBq given every 4 wk) or local standard of care (hydroxyurea, bevacizumab,...” PMID 40774695 Jan 2026

“Stepwise reduction in the dose, and ultimate discontinuation of, all non-belatacept immunosuppression (mycophenolate, sirolimus, everolimus, prednisone) guided by monitoring of...” NCT04177095

“Participants with PIK3CA gene mutations will receive a drug called Everolimus, which inhibits a protein called AKT that is thought to be a key factor in the development and...” NCT02208583

“We performed a multi-institutional, single-arm, phase II study of RAD001(everolimus), an oral inhibitor of mTOR, in patients who experienced treatment failure on first-line...” PMID 19047305 Dec 2008

“Patients will receive daily RAD001 (everolimus, per dose escalation scheme) plus concurrent docetaxel (75 mg/m2 intravenously every 3 weeks) + cisplatin (75 mg/m2 intravenously...” NCT00935961

“The RAPTOR (RAD001 in Advanced Papillary Tumor Program in Europe; ClinicalTrials.gov, NCT00688753) study evaluated first-line everolimus in patients with papillary metastatic...” PMID 27680407 Sep 2016

“Combination of everolimus also known as RAD001 (oral mammalian target of rapamycin (mTOR) inhibitor) and carboplatin may have activity in metastatic triple-negative breast...” PMID 24684785 Mar 2014

“The purpose of this study is to determine if RAD001 (everolimus) helps improve the standard treatment of XELOX-A (bevacizumab, oxaliplatin, capecitabine) in advanced solid tumors.” NCT00849550

“Conversion to Everolimus immunosuppression combined with mycophenolic acid (Myfortic: MPA), and complete discontinuation of Calcineurin inhibitor at 3 months post transplant.” NCT01936519

“After diagnosis of cGvHD patients will receive prednisone 1 mg/kg BW orally and everolimus (whole tablets or dispersible tablets) orally (targeted trough level 3-8 µg/l).” NCT01862965

“This is a phase II, two-stage, open-label, single-agent study of the experimental drug RAD001 (everolimus) in patients with previously treated small cell lung cancer.” NCT00374140

Everolimus with reduced calcineurin inhibitor- everolimus (target trough level of 3-8 ng/mL) in combination with reduced exposure to CNI (cyclosporine or tacrolimus)” NCT01950819

“Within the SOC arm, patients received single-agent bevacizumab (19), axitinib (18), everolimus (7), pazopanib (4), sorafenib (4), sunitinib (2), or temsirolimus (2).” PMID 28950297 Nov 2017

“RTOG 0913: a phase 1 study of daily everolimus (RAD001) in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma.” PMID 23725999 May 2013

“This study aims to evaluate the efficacy and safety of everolimus (Certirobell®) as adjuvant therapy in high-risk HCC patients following curative resection.” NCT06972758

“Participants will receive standard of care mTOR inhibitor therapy (Everolimus) in combination with AI therapy (Exemestane) in Step 2 Arm 2 and Step 3.” NCT05826964

Everolimus (C0 trough level of 3-8 ng/mL) in combination with reduced dose tacrolimus and steroids withdrawal at 6 months after transplant” NCT01544491

Everolimus at least 7-10 days prior to receiving the first dose of cemiplimab (Cycle 1, Day 1) and then daily while receiving Cemiplimab” NCT04339062

Everolimus, an oral inhibitor of mammalian target of rapamycin, can augment the efficacy of HER inhibitors in preclinical studies.” PMID 24057042 Sep 2013

“a switch from MPA to a mammalian target of rapamycin inhibitor (mTORi) everolimus, together with an adapted dose of tacrolimus” NCT07570433

Everolimus will be taken orally as a once-daily dose of 5 mg (one 5 mg tablet) from study day 1 until progression of disease.” NCT01283789

“Dose Finding Study of RAD001 (Everolimus, Afinitor®) in Combination With BEZ235 in Patients With Advanced Solid Tumors” NCT01482156

“Phase I study of sorafenib in combination with everolimus (RAD001) in patients with advanced neuroendocrine tumors.” PMID 23475104 Mar 2013

Everolimus is administered orally everyday to adult patients with relapsed or refractory non-Hodgkin's lymphoma” NCT00622258

“RAD001 (everolimus) 10mg daily administration orally until disease progression and/or intolerability” NCT00729482

“whether sensitivity to letrozole was enhanced with the oral mTOR inhibitor, everolimus (RAD001).” PMID 19380449 Apr 2009

“To assess the efficacy and safety of RAD001 (everolimus) in non-clear cell renal cell carcinoma” NCT00830895

“they receive the EveroHT regimen (everolimus plus trastuzumab and docetaxel) for two cycles.” NCT07239271

“4. Exemestane 25mg + everolimus 10mg oral administration every day (1 cycle = 4 weeks)” NCT06837792

“DTRMWXHS-12 oral capsules and everolimus oral tablets: daily x 21 days every 28 days” NCT02900716

“Treatment with Evero drug-coated balloon to apply local treatment with everolimusNCT07144150

“• A mammalian target of rapamycin (mTOR) inhibitor (everolimus or sirolimus)” NCT07124078

“• A mammalian target of rapamycin (mTOR) inhibitor (everolimus or sirolimus)” NCT06821542

everolimus has been shown to have single agent activity in relapsed myeloma” NCT01889420

“The study allowed SOC regimen is tacrolimus + sirolimus or everolimus.” NCT06552169

Everolimus (10 mg orally once daily on day 1 to 28 in a 28 day cycle)” NCT06849947

Everolimus will be continued if already started before the inclusion” NCT06254248

“mTOR inhibitors (everolimus or sirolimus), vedolizumab, ruxolitinib.” NCT05132166

“MTOR inhibitor + anti-estrogen therapy (everolimus + exemestane)” NCT04965688

“All patients were to receive 10mg everolimus (RAD001) daily.” NCT00529802

“RAD001 (everolimus) is a novel oral derivative of rapamycin.” NCT01047293

“Patients receive oral everolimus on days 1, 8, 15, and 21.” NCT00680758

“A Study of TS-1, Cisplatin (CDDP) and RAD001 (Everolimus)” NCT01096199

“CB-839 in combination with standard dose everolimusNCT02071862

“DTRM-555 (DTRMWXHS-12, everolimus and pomalidomide)” NCT04305444

“Drug: Lapatinib Drug: Everolimus Drug: Sorafenib” NCT03768375

“for AMG479 (ganitumab) and RAD001 (everolimus).” NCT01122199

“This group will receive Tacrolimus+Everolimus.” NCT01707849

Everolimus, 5 mg/day orally continuously.” NCT07522801

“RAD001 (everolimus) 10 mg per os daily.” NCT01625520

Everolimus: 10mg PO daily 16-18 weeks” NCT01163929

“Etoposide Everolimus Fludarabine” NCT02551718

“RAD001 (everolimus) + Cisplatin” NCT00858663

“1. PIK3CA, PTEN: EverolimusNCT02101385

“mTOR inhibitors: EverolimusNCT07173556

“exemestane plus everolimusNCT04869943

Everolimus (delayed)” NCT04104438

“RAD001 (everolimus)” NCT00303732

“RAD001 (Everolimus)” NCT01198665

“RAD001 (Everolimus)” NCT00449748

“RAD001 (everolimus)” NCT01042782

“RAd001 (Everolimus)” NCT01731158

EverolimusNCT02142036

NCT05189717

NCT00702052

NCT02454478

NCT00170794

NCT01379521

NCT04936971

NCT01059318

NCT00170820

NCT02155920

NCT03955172

NCT05252585

NCT00300274

NCT00170833

NCT01107509

NCT00863655

NCT00170846

NCT00695344

NCT00170885

NCT00170859

NCT04803318

NCT02294006

NCT00803816

NCT01058655

NCT01118065

NCT04802759

NCT01642186

NCT00387400

NCT03697408

NCT00943956

NCT01948960

NCT01648465

NCT00505102

NCT00096486

NCT00962507

NCT03950609

NCT01640743

NCT02201212

NCT01125293

NCT01714765

NCT07619950

NCT01007942

NCT02890069

NCT01216839

NCT01216826

NCT00811590

NCT00674414

NCT07218575

NCT06301386

NCT03198949

NCT05573126

NCT00828503

NCT06682611

NCT02015728

NCT02248571

NCT04591431

NCT02352844

NCT00828087

NCT01637194

NCT00363051

NCT01637090

NCT00934895

NCT00658320

NCT01636908

NCT01529554

NCT01234974

NCT01167530

NCT01636466

NCT03659136

NCT01005199

NCT01108445

NCT01272141

NCT05012371

NCT00510068

NCT01334502

NCT02451696

NCT02248012

NCT02152943

NCT00788060

NCT02962414

NCT00827359

NCT00420537

NCT03324373

NCT02531932

NCT02450175

NCT01954693

NCT01031446

NCT01164267

NCT02456857

NCT01055795

NCT01266148

NCT05108740

NCT02106507

NCT01789281

NCT01298713

NCT03468478

NCT01164176

NCT03032406

NCT06382948

NCT00582738

NCT00586443

NCT07340541

NCT05153668

NCT03632317

NCT01334073

NCT01857193

NCT01009801

NCT02539459

NCT02449538

NCT00933777

NCT05949541

NCT05522231

NCT01252251

NCT01715935

NCT07002177

NCT01281514

NCT05949658

NCT02017860

NCT01423708

NCT00419159

NCT00098007

NCT00775073

NCT01473732

NCT01061788

NCT05933395

NCT02205515

NCT04919226

NCT02013089

NCT01631058

NCT03577431

NCT01139138

NCT01009957

NCT03578432

NCT03014297

NCT02599324

NCT00514514

NCT05306340

NCT00812786

NCT02344550

NCT03328104

NCT03285802

NCT06428396

NCT03580239

NCT01628913

NCT00935792

NCT00515086

NCT02143726

NCT02871791

NCT00823459

NCT01217177

NCT02084446

NCT03654040

NCT01627067

NCT00402532

NCT00976573

NCT01960829

NCT06211790

NCT07062965

NCT00516412

NCT04818632

NCT01136733

NCT00097968

NCT02968927

NCT03284957

NCT00591734

NCT01626222

NCT03834740

NCT01525719

NCT03174171

NCT00443937

NCT01442090

NCT01625377

NCT03216967

NCT02208128

NCT05773274

NCT01169701

NCT01624948

NCT05954442

NCT01624766

NCT00521001

NCT00912340

NCT00423865

NCT04203901

NCT01935128

NCT00756340

NCT01793636

NCT00634920

NCT00519324

NCT01266837

NCT01332279

NCT01408004

NCT01034631

NCT01488487

NCT00390195

NCT00098553

NCT02236572

NCT02273752

NCT00862979

NCT06832189

NCT00402662

NCT01524783

NCT01427946

NCT01932177

NCT01653041

NCT03629847

NCT00390364

NCT01312064

NCT01931163

NCT01410448

NCT00425308

NCT04906304

NCT01376310

NCT06730672

NCT00655655

NCT03173560

NCT00622869

NCT00879333

NCT01929642

NCT00831480

NCT03176238

NCT00799188

NCT01706471

NCT00426049

NCT01927588

NCT01616186

NCT01349296

NCT03008408

NCT02049047

NCT02138929

NCT01399918

NCT02338609

NCT02338570

NCT01653847

NCT02036554

NCT00671112

NCT02864706

NCT01158651

NCT00976755

NCT02970630

NCT02493465

NCT01612299

NCT00805961

NCT00426530

NCT00426556

NCT07037238

NCT00915603

NCT01827384

NCT02120469

NCT01229943

NCT01051791

NCT00903188

NCT01157858

NCT01217931

NCT02909335

NCT03163667

NCT00414440

NCT00790400

NCT03839940

NCT00789828

NCT04199026

NCT00903175

NCT01281865

NCT00526591

NCT01523977

NCT00655252

NCT01864070

NCT02376985

NCT02233049

NCT01354301

NCT00965094

NCT06105632

NCT01609673

NCT00790036

NCT02860494

NCT02069093

NCT04355858

NCT01035229

NCT02334488

NCT01608412

NCT01014351

NCT01141309

NCT01088893

NCT00150046

NCT01446484

NCT01865747

NCT00107237

NCT05065411

NCT01784861

NCT03049189

NCT03458221

NCT00936702

NCT01197170

NCT00870337

NCT01111058

NCT00093639

NCT05476939

NCT00972335

NCT00149981

NCT01430572

NCT01276457

NCT05843253

NCT00618345

NCT02283658

NCT02333565

NCT04195750

NCT02332902

NCT05918302

NCT00930930

NCT04258423

NCT00918333

NCT00531063

NCT00531440

NCT00117702

NCT06994572

NCT00286624

NCT01419639

NCT02137837

NCT01070316

NCT02081755

NCT03386539

NCT05508906

NCT01068249

NCT06280950

NCT02520063

NCT02008019

NCT01374451

NCT00369161

NCT02915783

NCT05477576

NCT00820911

NCT03312738

NCT00966836

NCT03154281

NCT01185366

NCT03797196

NCT00886691

NCT02109913

NCT02954198

NCT01263951

NCT02269670

NCT00967044

NCT01470209

NCT01088048

NCT01269684

NCT02137239

NCT01545817

NCT01242631

NCT00636922

NCT03493152

NCT03493165

NCT00570921

NCT00458237

NCT01976390

NCT01700400

NCT04665739

NCT01595984

NCT02077556

NCT07191353

NCT01598987

NCT02091973

NCT01911546

NCT03387020

NCT02328963

NCT01783756

NCT00782626

NCT05124431

NCT00251004

NCT04542733

NCT01469572

NCT01469884

NCT02240719

NCT02616848

NCT01499160

NCT02258451

NCT03239015

NCT01784978

NCT01807767

NCT03596970

NCT00325325

NCT02842749

NCT00378014

NCT02031536

NCT00762632

NCT01596140

NCT01231399

NCT02742051

NCT01017029

NCT00412061

NCT01154439

NCT01154335

NCT01595009

NCT00377962

NCT02134899

NCT06727305

NCT06482086

NCT02254239

NCT02560012

NCT02134288

NCT01028092

NCT01594268

NCT02077933

NCT05594095

NCT04188548

NCT01661283

NCT01075321

NCT06126588

NCT02974686

NCT01548807

NCT01783444

NCT06658093

NCT01698918

NCT00890253

NCT00930475

NCT02291913

NCT01663805

NCT00154284

NCT01771458

NCT02056587

NCT03373903

NCT01313390

NCT02387099

NCT02836847

NCT01046045

NCT03245151

NCT00154297

NCT00411619

NCT01152801

NCT01259063

NCT00596557

NCT03139747

NCT01466231

NCT00154310

NCT00855114

NCT02228681

NCT00716573

NCT00160966

NCT02246127

NCT01231659

NCT01198158

NCT01215136

NCT00968253

NCT01077986

NCT01665768

NCT01668784

NCT01313559

NCT06943755

NCT06472388

NCT00876395

NCT01551212

NCT01843348

NCT05079360

NCT01178151

NCT02321501

NCT05833815

NCT04185883

NCT01087554

NCT01412515

NCT01099527

NCT07634601

NCT06584773

NCT04185831

NCT00869999

NCT00331409

NCT01270321

NCT00610948

NCT00727207

NCT02057133

NCT01797120

NCT03070301

NCT00809185

NCT01150097

NCT06317298

NCT01773460

NCT00567554

NCT01184326

NCT00332839

NCT03805399

NCT01079481

NCT02579044

NCT00954512

NCT00544999

NCT06942156

NCT01805271

NCT03095040

NCT00276575

NCT00597506

NCT02188719

NCT00085566

NCT01520103

NCT02687958

NCT05563220

NCT00968591

NCT04867720

NCT05501769

NCT01079702

NCT06561022

NCT01149434

NCT03878524

NCT01797523

NCT02029001

NCT01582191

NCT07477548

NCT06680921

NCT01582009

NCT04471441

NCT07318324

NCT01462214

NCT01854606

NCT04063865

NCT00814788

NCT02188550

NCT00434174

NCT05725200

NCT01508104

NCT01434602

NCT00985192

NCT04066114

NCT07407517

NCT02511639

NCT01804374

NCT05613166

NCT00464399

NCT01674140

NCT03256864

NCT05188118

NCT00255788

NCT00651482

NCT02028364

NCT00267189

NCT01263353

NCT01895049

NCT01114529

NCT02397083

NCT02061397

NCT00792766

NCT01734512

NCT01509560

NCT00187174

NCT03355794

NCT02736227

NCT05983107

NCT02732119

NCT07095933

NCT02569125

NCT02577458

NCT00373815

NCT01412892

NCT05835999

NCT02305810

NCT02695459

NCT03065387

NCT00767819

NCT02115113

NCT01218555

NCT01677390

NCT00981162

NCT01365468

NCT01453504

NCT07165886

NCT01780948

NCT02123823

NCT01239472

NCT02315625

NCT05429684

NCT01025817

NCT01190241

NCT02479490

NCT07165418

NCT01183247

NCT01387880

NCT01305941

NCT01289301

NCT05432518

NCT00553150

NCT01239342

NCT04395989

NCT00688623

NCT01678664

NCT01022996

NCT02216786

NCT02023905

NCT02113800

NCT01888432

NCT02985125

NCT00719264

NCT01680861

NCT00856505

NCT01888042

NCT02407509

NCT02724020

NCT03740334

NCT00371826

NCT00466466

NCT03525834

NCT01042028

NCT00436618

NCT01023542

NCT02314312

NCT04849533

NCT01514448

NCT00560963

NCT00949949

NCT02096107

NCT01997255

NCT02125084

NCT02062892

NCT00770120

NCT01204476

NCT03114527

NCT01730209

NCT02504892

NCT01133678

NCT00955773

NCT02638428

NCT01404325

NCT07024173

NCT01878786

NCT01023815

NCT03415750

NCT02429869

NCT02711826

NCT00857259

NCT04485559

NCT02025712

NCT07426484

NCT01567488

NCT01567475

NCT02313051

NCT01998789

NCT01566279

NCT07435584

NCT05749588

NCT00805129

NCT01115803

NCT02811861

NCT01561404

NCT03112603

NCT03616587

NCT01276834

NCT05293964

NCT01455649

NCT02404051

NCT01120249

NCT01024946

NCT01801137

NCT02813135

NCT01182168

NCT01563354

NCT02812940

NCT06789900

NCT03352427

Known as Afinitor “Everolimus (Afinitor) is a single agent which was evaluated and demonstrated efficacy in randomized phase III study (RECORD-1) in metastatic RCC patients after failure of...” NCT02056587
12

“An Open-label, Single-dose Study to Assess the Pharmacokinetics of Oral Everolimus (Afinitor®) in Subjects With Impaired Hepatic Function” NCT00968591

“Therefore, everolimus (Afinitor®) is being tested in specific diseases to stop cells from growing too fast (as in cancer).” NCT02188550

“test two of these drugs, Rapamycin (Sirolimus) and Everolimus (Afinitor), in healthy older adults” NCT06658093

“Everolimus (Afinitor) 10 mg tablet once daily.” NCT01865747

“Oral Everolimus (RAD001, Afinitor®)” NCT01379521

“Everolimus (Afinitor) tablets” NCT07435584

“Everolimus (Afinitor®)” NCT02113800

“Everolimus (Afinitor®)” NCT06680921

“Everolimus (Afinitor®)” NCT06789900

“Everolimus (Afinitor®)” NCT01801137

Afinitor (everolimus)” NCT03198949

NCT05490095

Known as AfinitorTM “Everolimus (AfinitorTM) is approved by the FDA for the treatment of advanced renal cell carcinoma” NCT01061788
Known as Afintor “* Everolimus (Afintor™) is a pill that works by blocking the activity of a substance in the body known as mTOR (mammalian target of rapamycin).” NCT01055795
Known as BU-Everolimus “Drug: BU-EverolimusNCT01023542
Known as Certican “Safety and Efficacy of the Early Introduction of Everolimus (Certican®) With Low Dose of Cyclosporine in de Novo Kidney Recipients After 1 Month of Transplantation” NCT01706471
13

“everolimus (Certican ®): 4 to 6 mg/day started at D5, adjusted to achieve a residual level between 6 et 10 ng/ml” NCT01028092

“Valganciclovir will be administered and Certican (everolimus) will be added as immunosuppression” NCT00828503

“Everolimus (Certican®) was provided in blisters containing tablets of 0.25 mg and 0.75 mg.” NCT01023815

“Commercially available everolimus (Certican®), oral route, was used.” NCT02864706

“Everolimus (Certican®) and reduced dose of Cyclosporine A (Neoral®)” NCT02328963

“Patients will received everolimus (CERTICAN), oral form” NCT03955172

“Everolimus (Certican)” NCT00098007

NCT00504543

NCT01399242

NCT00098241

NCT00443508

NCT01596062

NCT01079143

Known as Certirobell “This study aims to evaluate the efficacy and safety of everolimus (Certirobell®) as adjuvant therapy in high-risk HCC patients following curative resection.” NCT06972758
Known as ERL “different immunosuppressive regimens (cyclosporine A [CsA]/MMF, Tacr/MMF, Tacr/MMF with conversion to Tacr/Everolimus [ERL]) or by cytokine promoter gene polymorphisms may...” NCT00160966
Known as EVE “We subsequently tested the effects of transient versus chronic inhibition of autophagy with chloroquine or hydroxychloroquine (HCQ) and mTOR signaling with rapamycin (RAPA) or...” PMID 40897974 Sep 2025
4

“We report a single-center phase I/II trial exploring the combination of everolimus (EVE) and mycophenolate mofetil (MMF) as calcineurin inhibitor (CNI)-free GVHD prophylaxis” PMID 33755792 Mar 2021

Everolimus (EVE) and sorafenib (SOR) combination was associated with synergistic activity in preclinical models.” PMID 36840749 Feb 2023

“Evaluation of Early Use of Everolimus (EVE) on Cytomegalovirus (CMV) Infection in Renal Transplant Recipients” NCT01927588

“patients receiving everolimus (EVE) and exemestane (EXE)” PMID 33413212 Jan 2021

Known as Everolimus: Certican Everolimus: Certican®” NCT01509560
Known as EVL “Kidney transplant manteinance treatment with Tacrolimus (TAC) to achieve 4-6 ng/mL trough levels, Everolimus (EVL) to achieve 3-8 ng/mL trough levels and Corticosteroids (CS)...” NCT04936971
2

“followed by either steroid withdrawal (CsA/MPA) or replacement of cyclosporine with everolimus (EVL)” PMID 33277746 Dec 2020

“Drug: Everolimus(EVL)” NCT02137239

Known as EVR “Here, in this randomized, multicenter, controlled trial (BKEVER study), we sought to evaluate the impact of everolimus (EVR) in facilitating the clearance of BKPyV compared to...” PMID 39490986 Oct 2024
10

“Participants were randomised (1:1) to receive everolimus with reduced-exposure calcineurin inhibitor (EVR+rCNI) or mycophenolic acid with standard-exposure CNI (MPA+sCNI).” PMID 34620664 Oct 2021

“Everolimus (EVR) was associated with lower incidence of viral infections and also the lowest incidence of neoplasms.” NCT01653041

“were randomized to receive everolimus (EVR) + mycophenolic acid (MPA) or were maintained on tacrolimus (TAC) + MPA.” PMID 27648523 Oct 2016

“Notch signaling, possibly modulated by everolimus (EVR), is essential for processes involved in CAV.” PMID 30312541 Nov 2018

“and everolimus (EVR), have distinct pharmacokinetic/pharmacodynamics properties.” PMID 37525373 Aug 2023

“receive everolimus + reduced-exposure tacrolimus (EVR + rTAC; n = 52)” PMID 32406111 Jun 2020

“start everolimus+reduced tacrolimus (EVR+rTAC)” PMID 29237235 Jan 2018

“everolimus (EVR), low-dose tacrolimus (LTac)” PMID 28141897 Mar 2017

“everolimus (EVR) + reduced tacrolimus (TAC)” PMID 28817434 Dec 2017

“everolimus (EVR)” PMID 33988338 Feb 2022

Known as RAD “This is a treatment protocol designed only to provide access to everolimus (RAD) for maintenance immunosuppression.” NCT00149981
Known as RAD-001 “This study will assess whether everolimus (RAD001) is effective in preventing cyst and kidney expansion as well as worsening of renal function in patients with ADPKD and...” NCT00414440
180

“We conducted a phase Ib trial combining RAD001 (everolimus), an allosteric inhibitor of mTORC1, and conventional chemotherapy, in AML patients under 65 years of age at first...” PMID 23321953 Jan 2013

“A phase I study of temozolomide and everolimus (RAD001) in patients with newly diagnosed and progressive glioblastoma either receiving or not receiving enzyme-inducing...” PMID 22160854 Dec 2011

“North Central Cancer Treatment Group Phase I trial N057K of everolimus (RAD001) and temozolomide in combination with radiation therapy in patients with newly diagnosed...” PMID 20864273 Sep 2010

“Everolimus (RAD-001) is an orally active rapamycin analogue shown in preclinical data to produce cytostatic cell inhibition, which may be potentially beneficial in treating melanoma.” PMID 29666297 Apr 2018

“A Phase II Study of Carboplatin (CBDCA), Paclitaxel (TAXOL), and Everolimus (RAD001) in Previously Untreated Patients With Measurable Disease With Cancer of Unknown Primary (CUP)” NCT00936702

“UPCC 36315 A Phase II Study Of Everolimus (RAD001) And Lenvatinib (E7080) In Patients With Metastatic Differentiated Thyroid Cancer Who Have Progressed on Lenvatinib alone” NCT03139747

“A Phase I Trial to Evaluate Acute and Late Toxicities of Concurrent Treatment With Everolimus (RAD001) and Radio-Hormonotherapy in High-risk Prostate Cancer.(RHOMUS)” NCT00943956

“RTOG 0913: a phase 1 study of daily everolimus (RAD001) in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma.” PMID 23725999 May 2013

“RAD001 will be taken orally starting at a dose of 30 mg every week for the first cohort of patients, one hour prior to administration of patupilone.” NCT00496600

“Phase II study of temozolomide (TMZ) and everolimus (RAD001) therapy for metastatic melanoma: a North Central Cancer Treatment Group study, N0675.” PMID 23357973 Aug 2014

“Everolimus (RAD001) With Basiliximab, Corticosteroids and Lower Levels Versus Higher Levels of Tacrolimus in de Novo Renal Transplant Recipients” NCT00170833

“This is an open-label, multicenter, single-arm, phase II clinical trial of Everolimus (RAD001) in patients with segmental overgrowth syndrome.” NCT02569125

“A Phase I Trial of the IGF-1R Antibody AMG 479 in Combination With Everolimus (RAD001) and Panitumumab in Patients With Advanced Cancer” NCT01061788

“A Phase I Study of Weekly Low-Dose Cisplatin Plus Escalating Doses of Oral RAD001(Everolimus) for Patients With Advanced Solid Tumors” NCT00423865

“Everolimus (RAD001) for the Treatment of Malignant Pleural Mesothelioma With Merlin/NF2 Loss as a Biomarker to Predict Sensitivity” NCT01024946

“Phase I/II Study of Hyper-CVAD Plus RAD001 (Everolimus) for Patients With Relapsed or Refractory Acute Lymphocytic Leukemia (ALL)” NCT00968253

“A Phase I and Feasibility Study of Everolimus (RAD001) Plus R-CHOP for New Untreated Diffuse Large B-Cell Lymphoma (DLBCL)” NCT01334502

“Dose Finding Study of RAD001 (Everolimus, Afinitor®) in Combination With BEZ235 in Patients With Advanced Solid Tumors” NCT01482156

“SWOG S0722: phase II study of mTOR inhibitor everolimus (RAD001) in advanced malignant pleural mesothelioma (MPM).” PMID 25611229 Feb 2015

“Everolimus (RAD001, Novartis), an oral derivative of rapamycin, inhibits the mammalian target of rapamycin (mTOR)” PMID 16951235 Sep 2006

“Treatment of Patients Suffering From a Progressive Pancreas Carcinoma With Everolimus (RAD001) and Gemcitabine” NCT00560963

“Everolimus (RAD001) is supplied by Novartis until Everolimus is commercially available for the study setting.” NCT01626222

“Phase II trial of capecitabine and everolimus (RAD001) combination in refractory gastric cancer patients.” PMID 24013904 Sep 2013

“whether sensitivity to letrozole was enhanced with the oral mTOR inhibitor, everolimus (RAD001).” PMID 19380449 Apr 2009

“Everolimus (RAD001), a rapamycin analogue, is an orally administered inhibitor of mTOR.” NCT01283789

“Efficacy and Safety of Everolimus (RAD001) in Patients With Advanced Gastric Cancer” NCT00519324

“RAD001 is an orally administered cell cycle inhibitor with antitumor activity.” NCT00827567

“Everolimus (RAD001), a new inhibitor for mammalian target of rapamycin (mTOR)” PMID 24886512 May 2014

“RAD001 (tablets; 2.5mg) is administered daily at 5, 7.5, 10 mg.” NCT01148628

“Everolimus (RAD001) is a novel oral derivative of rapamycin.” NCT00805129

“RAD001 (Everolimus), an inhibitor of the mTOR molecule” NCT00567554

“Oral mTOR-inhibitor Everolimus (RAD001) 10 mg Daily” NCT01412515

“RAD001 (Everolimus) in combination with carboplatin” NCT00930475

“experimental drug RAD001C (RAD001, Everolimus)” NCT00187174

“Everolimus (RAD001) 4 mg initial daily dose.” NCT00170846

“Everolimus (RAD001) with MMF and Steroids” NCT03596970

“Oral Everolimus (RAD001, Afinitor®)” NCT01379521

“Everolimus (RAD-001) and Gefitinib” NCT00085566

“Everolimus is also called RAD001.” NCT01252251

“Letrozole and RAD001 (Everolimus)” NCT01068249

“Gefitinib and Everolimus (RAD001)” NCT00096486

“BEZ235 plus everolimus (RAD001)” NCT03373903

“Everolimus (RAD001) , Afinitor®” NCT01419639

“Everolimus (also called RAD001)” NCT01182168

“Drug: Everolimus (RAD001)” NCT00369161

“Drug: RAD001(everolimus)” NCT00719264

“Everolimus (RAD 001)” NCT01111058

“Everolimus (RAD001)” NCT01857193

“everolimus (RAD001)” NCT00426530

“RAD001 (Everolimus)” NCT01954693

“Everolimus (RAD001)” NCT00788060

“Everolimus (RAD001)” NCT00154297

“RAD001 (everolimus)” NCT01167530

“Everolimus (RAD001)” NCT00419159

“everolimus (RAD001)” NCT00792766

“Everolimus (RAD001)” NCT00531063

“Everolimus (RAD001)” NCT01365468

“Everolimus (RAD001)” NCT01548807

“Everolimus (RAD001)” NCT00531440

“Everolimus (RAD001)” NCT01595009

“Everolimus (RAD001)” NCT00857259

“Everolimus (RAD001)” NCT00371826

“Everolimus (RAD001)” NCT00170794

“RAD001: Everolimus” NCT01412892

“RAD001(Everolimus)” NCT00636922

“RAD001” NCT01009801

NCT00632268

NCT00446368

NCT01058408

NCT01713946

NCT01226056

NCT00828594

NCT00630344

NCT01248403

NCT00499603

NCT00422344

NCT01057277

NCT00629525

NCT00657982

NCT00827567

NCT00973713

NCT00849550

NCT00384969

NCT01482299

NCT01009346

NCT00303732

NCT01031381

NCT00401778

NCT00448149

NCT00087685

NCT01341834

NCT00933374

NCT00449748

NCT00976248

NCT01939418

NCT01206764

NCT00516165

NCT01333085

NCT00576680

NCT00935961

NCT01625520

NCT01063478

NCT01345136

NCT00807755

NCT00830895

NCT00804336

NCT00942734

NCT00942682

NCT00522665

NCT01127763

NCT01490476

NCT00574769

NCT01490749

NCT01491672

NCT00858663

NCT00317720

NCT00714025

NCT00574366

NCT01051570

NCT01188889

NCT04895748

NCT01544491

NCT00529802

NCT00936858

NCT00978432

NCT01830153

NCT00113360

NCT00323739

NCT01743560

NCT00456833

NCT00457119

NCT00457964

NCT01049620

NCT01175096

NCT00392821

NCT01324492

NCT01048723

NCT00459186

NCT01122199

NCT01275222

NCT01074086

NCT01047293

NCT00613132

NCT00819546

NCT01152840

NCT01152827

NCT00967928

NCT00729638

NCT00640978

NCT00729482

NCT01590199

NCT00124280

NCT01096199

NCT02991807

NCT01283334

NCT00410124

NCT00956293

NCT01198665

NCT00985374

NCT00607113

NCT00253318

NCT00409292

NCT00374140

NCT01510119

NCT00703807

NCT00688753

NCT00406276

NCT00478634

NCT00337545

NCT00474929

NCT00843531

NCT00466102

NCT01317615

NCT00927966

NCT01514110

NCT00473005

NCT00081874

NCT01289912

NCT00892801

NCT01880749

Known as RAD001 (Everolimus) RAD001 (Everolimus)NCT01226056
3

RAD001 (Everolimus)NCT01063478

RAD001 (everolimus)NCT01042782

“RAD001-Everolimus” NCT00613132

Known as RAD001C “experimental drug RAD001C (RAD001, Everolimus)” NCT00187174
Known as sirolimus “Everolimus (sirolimus) is an inhibitor of the mammalian target of rapamycin (mTOR).” NCT07095933
Known as Votubia “Verum and placebo were provided by Novartis (Basel, Switzerland), including funding to cover the manufacturing and provision of everolimus (Votubia) tablets and the...” PMID 36049557 Aug 2022
2

“PTEN-loss only Votubia® (everolimus): 2.5 mg tablets.” NCT02233049

VotubiaNCT07634601

Known as Zortress “The purpose of this study is to test the safety and effectiveness of everolimus (Zortress®) in preventing antibody formation in patients with chronic failing kidney transplants.” NCT01636466
4

“Biomarkers Predicting Successful Tacrolimus Withdrawal and Everolimus (Zortress) Monotherapy Early After Liver Transplantation” NCT02736227

“Patients are supplied everolimus (Zortress) + prograf” NCT01911546

Zortress® /Everolimus” NCT01612299

ZortressNCT07634601

Action Inhibit “designed to block proteins that are important in the development and growth of cancer” NCT00081874
Modality Small molecule “Everolimus is a semisynthetic macrocyclic lactone” NCT00117702
Route Oral “you will receive treatment with RAD001 by mouth every day” NCT00081874
Target MTOR “the mammalian target-of-rapamycin inhibitor everolimus” PMID 20871262 Oct 2010