drugset / Trial / NCT07318324
Phase Ib Study of Avutometinib, Defactinib, and Everolimus in RAS Pathway Mutant Endometrial Cancer
Non-randomizedSingle-groupOpen-labelTreatment
Summary
To find the recommended dose of the combination of avutometinib, defactinib, and everolimus in patients with endometrial cancer that is recurrent and has abnormal RAS activity. The safety and effects of this combination will also be studied.
Timeline
- Start
- 2026-05-13
- Primary completion
- 2028-08-01
- Completion
- 2030-08-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Avutometinib | Small molecule | — | Oral |
| Subject | Defactinib | Small molecule | — | Oral |
| Subject | Everolimus | Small molecule | — | Oral |