drugset / Trial / NCT02551718
High Throughput Drug Sensitivity Assay and Genomics- Guided Treatment of Patients With Relapsed or Refractory Acute Leukemia
NaSingle-groupOpen-labelTreatment
Summary
This pilot clinical trial studies the feasibility of choosing treatment based on a high throughput ex vivo drug sensitivity assay in combination with mutation analysis for patients with acute leukemia that has returned after a period of improvement (relapsed) or does not respond to treatment (refractory). A high throughput screening assay tests many different drugs individually or in combination that kill leukemia cells in tiny chambers at the same time. High throughput drug sensitivity assay and mutation analysis may help guide the choice most effective for an individual's acute leukemia.
Timeline
- Start
- 2015-09-11
- Primary completion
- 2020-06-19
- Completion
- 2021-05-13
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Afatinib | Small molecule | — | — |
| Subject | Axitinib | Small molecule | — | — |
| Subject | Azacitidine | Other / unclassified | — | — |
| Subject | Bexarotene | Small molecule | — | — |
| Subject | Bortezomib | Small molecule | — | — |
| Subject | Bosutinib | Small molecule | — | — |
| Subject | Busulfan | Small molecule | — | — |
| Subject | Cabazitaxel | Other / unclassified | — | — |
| Subject | Cabozantinib | Small molecule | — | — |
| Subject | Carfilzomib | Other / unclassified | — | — |
| Subject | Ceritinib | Small molecule | — | — |
| Subject | Cladribine | Small molecule | — | — |
| Subject | Clofarabine | Other / unclassified | — | — |
| Subject | Cytarabine | Small molecule | — | — |
| Subject | Dabrafenib | Small molecule | — | — |
| Subject | Daunorubicin | Small molecule | — | — |
| Subject | Decitabine | Small molecule | — | — |
| Subject | Erlotinib | Small molecule | — | — |
| Subject | Etoposide | Small molecule | — | — |
| Subject | Everolimus | Small molecule | — | — |
| Subject | Fludarabine | Small molecule | — | — |
| Subject | Gefitinib | Small molecule | — | — |
| Subject | Gemcitabine | Small molecule | — | — |
| Subject | Hydroxyurea | Other / unclassified | — | — |
| Subject | Imatinib | Small molecule | — | — |
| Subject | In Vitro Sensitivity-Directed Chemotherapy | Unknown | — | — |
| Subject | Irinotecan | Small molecule | — | — |
| Subject | Lapatinib | Small molecule | — | — |
| Subject | Lomustine | Small molecule | — | — |
| Subject | MERCAPTOPURINE ANHYDROUS | Small molecule | — | — |
| Subject | Melphalan | Small molecule | — | — |
| Subject | Methotrexate | Small molecule | — | — |
| Subject | Mitoxantrone | Small molecule | — | — |
| Subject | Nelarabine | Small molecule | — | — |
| Subject | Nilotinib | Small molecule | — | — |
| Subject | Paclitaxel | Small molecule | — | — |
| Subject | Pazopanib | Small molecule | — | — |
| Subject | Pentostatin | Small molecule | — | — |
| Subject | Ponatinib | Small molecule | — | — |
| Subject | Pralatrexate | Other / unclassified | — | — |
| Subject | Rapamycin | Small molecule | — | — |
| Subject | Regorafenib | Small molecule | — | — |
| Subject | Romidepsin | Peptide | — | — |
| Subject | Ruxolitinib | Small molecule | — | — |
| Subject | Sorafenib | Small molecule | — | — |
| Subject | Sunitinib | Small molecule | — | — |
| Subject | Temsirolimus | Small molecule | — | — |
| Subject | Thioguanine | Small molecule | — | — |
| Subject | Topotecan | Small molecule | — | — |
| Subject | Trametinib | Small molecule | — | — |
| Subject | Tretinoin | Unknown | — | — |
| Subject | arsenic trioxide | Small molecule | — | — |
| Subject | dasatinib anhydrous | Small molecule | — | — |