Drugs / Thioguanine
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Thioguanine

Small molecule

Developed for
leukemia · lymphoblastic lymphoma · acute lymphoblastic leukemia · myelodysplastic syndrome · acute myeloid leukemia · adult acute lymphoblastic leukemia · B-cell childhood acute lymphoblastic leukemia · childhood acute myeloid leukemia
+30 more · lymphoma · acute basophilic leukemia · acute erythroid leukemia · acute leukemia · acute leukemia of ambiguous lineage · acute monocytic leukemia · acute myeloblastic leukemia with maturation · acute myeloblastic leukemia without maturation · acute myeloid leukemia with minimal differentiation · acute myelomonocytic leukemia M4 · B-cell acute lymphoblastic leukemia · B-lymphoblastic leukemia/lymphoma with hypodiploidy · B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) · brain neoplasm · childhood acute lymphoblastic leukemia · childhood acute megakaryoblastic leukemia · childhood myelodysplastic syndrome · Hodgkins lymphoma · Langerhans cell histiocytosis · lymphoid leukemia · metastatic malignant neoplasm · mixed phenotype acute leukemia · myeloid leukemia associated with down syndrome · non-Hodgkin lymphoma · precursor B-cell acute lymphoblastic leukemia · T-cell acute lymphoblastic leukemia · urinary bladder cancer · urothelial carcinoma · brain cancer · glioblastoma
Investigated by
National Cancer Institute (NCI) · Children's Oncology Group · Deutsche Krebshilfe e.V., Bonn (Germany) · Goethe University · Johann Wolfgang Goethe University Hospital · Kjeld Schmiegelow
+31 more · M.D. Anderson Cancer Center · Medical Research Council · Memorial Sloan Kettering Cancer Center · SWOG Cancer Research Network · Aalborg University Hospital · Aarhus University Hospital Skejby · Alliance for Clinical Trials in Oncology · Columbia University · Danish Child Cancer Foundation · EsPhALL · GIMEMA Foundation · German Federal Ministry of Education and Research · Grupo Argentino de Tratamiento de la Leucemia Aguda · Italian Association of Pediatric Hematology and Oncology · Jazz Pharmaceuticals · Kristoffer Rohrberg · Leukemia Research Fund · National University Hospital, Singapore · National University of Singapore · Nordic Society for Pediatric Hematology and Oncology · Odense University Hospital · Rutgers, The State University of New Jersey · St. Jude Children's Research Hospital · Takeda · United Kingdom Children's Cancer Study Group · University Hospital Muenster · University Hospital Schleswig-Holstein · University Hospital, Motol · University Medical Center Hamburg-Eppendorf · University of Michigan Rogel Cancer Center · University of Washington

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) THIOGUANINE 1966-01-18 fda.gov

Trials 47 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT00004056 Oct 1999 → Oct 2002 leukemia Children's Oncology Group Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT05276284 Sep 2022 → Dec 2024 metastatic malignant neoplasm Kristoffer Rohrberg Completed No outcome recorded
Phase 1/2 NCT02912676 Oct 2016 → Mar 2020 acute lymphoblastic leukemia, lymphoblastic lymphoma Kjeld Schmiegelow Completed No outcome recorded
Phase 1/2 NCT02141100 Jul 2014 → Oct 2016 non-Hodgkin lymphoma Kjeld Schmiegelow Withdrawn No outcome recorded
Phase 214 trials
Phase 2 NCT06351306 Apr 2024 acute myeloid leukemia Columbia University Withdrawn No outcome recorded
Phase 2 NCT04845035 Jan 2024 → Jan 2026 acute lymphoblastic leukemia University of Michigan Rogel Cancer Center Withdrawn No outcome recorded
Phase 2 NCT02788201 Mar 2017 → Oct 2019 urinary bladder cancer, urothelial carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT02419469 Nov 2015 → Jun 2017 lymphoblastic lymphoma, precursor B-cell acute lymphoblastic leukemia M.D. Anderson Cancer Center Terminated No outcome recorded
Phase 2 NCT01451515 May 2012 → May 2021 lymphoblastic lymphoma St. Jude Children's Research Hospital Completed No outcome recorded
Phase 2 NCT00558519 Mar 2008 → Sep 2016 lymphoid leukemia Alliance for Clinical Trials in Oncology Completed No outcome recorded
Phase 2 NCT00866749 Sep 2006 → Jul 2018 lymphoblastic lymphoma M.D. Anderson Cancer Center Completed No outcome recorded
Phase 2 NCT00109837 Apr 2005 → Nov 2010 leukemia SWOG Cancer Research Network Completed No outcome recorded
Phase 2 NCT00176462 Feb 2001 → Sep 2008 acute lymphoblastic leukemia Rutgers, The State University of New Jersey Completed No outcome recorded
Phase 2 NCT00003671 Dec 1998 → Nov 2002 leukemia Children's Oncology Group Completed No outcome recorded
Phase 322 trials
Phase 3 NCT03007147 Aug 2017 → Sep 2027 expected B-cell acute lymphoblastic leukemia, T-cell acute lymphoblastic leukemia, mixed phenotype acute leukemia Children's Oncology Group Active not recruiting No outcome recorded
Phase 3 NCT02521493 Dec 2015 → Jun 2024 overdue Down syndrome, myelodysplastic syndrome, myeloid leukemia associated with down syndrome Children's Oncology Group Active not recruiting No outcome recorded
Phase 3 NCT01190930 Aug 2010 → Mar 2019 B-cell childhood acute lymphoblastic leukemia, B-lymphoblastic leukemia/lymphoma with hypodiploidy, B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2), Down syndrome +1 Children's Oncology Group Completed No outcome recorded
Phase 3 NCT06211452 Aug 2007 → Mar 2015 childhood acute myeloid leukemia Grupo Argentino de Tratamiento de la Leucemia Aguda Completed No outcome recorded
Phase 3 NCT00369317 Mar 2007 → Dec 2013 acute basophilic leukemia, acute erythroid leukemia, acute monocytic leukemia, acute myeloblastic leukemia with maturation +6 Children's Oncology Group Completed No outcome recorded
Phase 3 NCT00103285 Apr 2005 → Dec 2013 B-cell childhood acute lymphoblastic leukemia Children's Oncology Group Completed No outcome recorded
Phase 3 NCT00764907 Nov 2002 → Oct 2007 leukemia University Hospital, Motol Unknown No outcome recorded
Phase 3 NCT00613457 Sep 2000 → Jul 2006 leukemia Italian Association of Pediatric Hematology and Oncology Completed No outcome recorded
Phase 3 NCT00430118 Jul 2000 → Jan 2012 leukemia University Hospital Schleswig-Holstein Completed No outcome recorded
Phase 3 NCT00005945 Jun 2000 → Nov 2007 leukemia Children's Oncology Group Completed No outcome recorded
Phase 44 trials
Phase 4 NCT02894645 Oct 2008 → Oct 2018 childhood acute lymphoblastic leukemia National University Hospital, Singapore Unknown No outcome recorded
Phase 4 NCT00199017 Apr 2004 → Mar 2009 lymphoblastic lymphoma Johann Wolfgang Goethe University Hospital Completed No outcome recorded
Phase 4 NCT00199056 Oct 1999 → Nov 2003 adult acute lymphoblastic leukemia Goethe University Completed No outcome recorded
Phase 4 NCT00199069 Apr 1993 → Jan 1999 adult acute lymphoblastic leukemia Goethe University Completed No outcome recorded
Phase not applicable3 trials
NCT02551718 Sep 2015 → Jun 2020 acute leukemia of ambiguous lineage, acute lymphoblastic leukemia University of Washington Completed No outcome recorded
NCT01156883 Apr 2010 → Oct 2017 leukemia GIMEMA Foundation Completed No outcome recorded
NCT00343369 Jan 2003 → ? leukemia University Medical Center Hamburg-Eppendorf Unknown No outcome recorded
Also used as a comparator or background therapy in 49 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT03571321 Background May 2019 → Sep 2026 expected childhood acute lymphoblastic leukemia University of Chicago Recruiting No outcome recorded
Phase 1 NCT00866307 Background Feb 2009 → Jun 2014 B-cell adult acute lymphocytic leukemia, B-cell childhood acute lymphoblastic leukemia Children's Oncology Group Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT00439296 Background May 2006 → May 2009 childhood acute lymphoblastic leukemia Therapeutic Advances in Childhood Leukemia Consortium Terminated No outcome recorded
Phase 214 trials
Phase 2 NCT07636564 Background Oct 2026 → Apr 2031 expected B-cell acute lymphoblastic leukemia, T-cell acute lymphoblastic leukemia, acute leukemia of ambiguous lineage SWOG Cancer Research Network Not yet recruiting No outcome recorded
Phase 2 NCT06317662 Background Jun 2025 → Dec 2028 expected B-cell acute lymphoblastic leukemia, acute leukemia of ambiguous lineage National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 2 NCT06124157 Background May 2025 → Dec 2030 expected B-cell acute lymphoblastic leukemia National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 2 NCT06533748 Background Jan 2025 → May 2028 expected lymphoblastic lymphoma, precursor B-cell acute lymphoblastic leukemia St. Jude Children's Research Hospital Recruiting No outcome recorded
Phase 2 NCT06390319 Background Dec 2024 → Dec 2027 expected T-cell acute lymphoblastic leukemia, T-cell non-Hodgkin lymphoma, mixed phenotype acute leukemia St. Jude Children's Research Hospital Recruiting No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT07072585 Background Aug 2026 → Sep 2035 expected T-cell acute lymphoblastic leukemia, T-lymphoblastic lymphoma Children's Oncology Group Not yet recruiting No outcome recorded
Phase 2/3 NCT03117751 Background Mar 2017 → Sep 2026 expected lymphoblastic leukemia, acute, with lymphomatous features St. Jude Children's Research Hospital Active not recruiting No outcome recorded
Phase 2/3 NCT01228331 Comparator Oct 2010 → Dec 2019 leukemia University Medical Center Hamburg-Eppendorf Completed No outcome recorded
Phase 325 trials
Phase 3 NCT06059989 Background Nov 2021 → Jun 2025 overdue Crohn disease, inflammatory disease Academic Medical Center - University of Amsterdam Recruiting No outcome recorded
Phase 3 NCT03959085 Background Oct 2019 → Mar 2032 expected B-cell acute lymphoblastic leukemia, central nervous system leukemia, lymphoblastic lymphoma, mixed phenotype acute leukemia +1 Children's Oncology Group Recruiting No outcome recorded
Phase 3 NCT04043494 Background Aug 2019 → Apr 2030 expected lymphoblastic lymphoma University Hospital Muenster Recruiting No outcome recorded
Phase 3 NCT03914625 Background Jul 2019 → Sep 2027 expected B-cell acute lymphoblastic leukemia, Down syndrome, lymphoblastic lymphoma National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 3 NCT03643276 Background Jul 2018 → Jul 2028 expected childhood acute lymphoblastic leukemia Martin Schrappe Recruiting No outcome recorded
Phase 42 trials
Phase 4 NCT00199004 Background Apr 2004 → Mar 2009 adult acute lymphoblastic leukemia Johann Wolfgang Goethe University Hospital Completed No outcome recorded
Phase 4 NCT00198991 Background Apr 2003 → Jun 2011 adult acute lymphoblastic leukemia Goethe University Completed No outcome recorded
Phase not applicable2 trials
NCT00550992 Background Jan 2006 → Dec 2020 leukemia Dutch Childhood Oncology Group Unknown No outcome recorded
NCT00016302 Background Apr 2001 → Jul 2007 T-cell childhood acute lymphocytic leukemia National Cancer Institute (NCI) Completed No outcome recorded

Evidence & citations 16 cited values

Every value below carries the sentence it was read from. 98 sources stand behind the page.

FieldValueCited text
Known as Thioguanine “with varied cycles, including Daunorubicin, Vincristine, Prednisone, Pegaspargase, Rituximab, Cytarabine, Mercaptopurine, Cyclophosphamide, Methotrexate, Doxorubicin,...” NCT04845035
83

“If participants are already using azathioprine or thioguanine, they will receive continued dosing 2-2.5mg/kg or 20mg once daily, respectively” NCT06059989

“Temsirolimus Thioguanine Topotecan HCl” NCT02551718

“Teniposide, Thioguanine, Thiotepa” NCT02788201

“Drug: ThioguanineNCT03117751

ThioguanineNCT02665065

NCT00866749

NCT03150693

NCT00866307

NCT02660762

NCT07636564

NCT01190930

NCT02112916

NCT06210750

NCT06390319

NCT00003423

NCT00002665

NCT02883049

NCT00002517

NCT00002658

NCT00671034

NCT02419469

NCT02894645

NCT06336395

NCT00004056

NCT06533748

NCT00004228

NCT00549848

NCT00558519

NCT00343369

NCT00266136

NCT00764907

NCT00002744

NCT03007147

NCT03959085

NCT04043494

NCT00002944

NCT01117441

NCT00005596

NCT00005945

NCT00005823

NCT00186966

NCT06124157

NCT00109837

NCT00199017

NCT02723994

NCT02521493

NCT00075725

NCT00003437

NCT01228331

NCT00199056

NCT07072585

NCT00550992

NCT01156883

NCT00198991

NCT03914625

NCT00103285

NCT01451515

NCT06351306

NCT00002816

NCT00002701

NCT00002812

NCT00005603

NCT02912676

NCT00002531

NCT00003671

NCT00275106

NCT00002514

NCT00199004

NCT06317662

NCT02828358

NCT03571321

NCT00003728

NCT02101853

NCT00408005

NCT00613457

NCT00002590

NCT00005585

NCT00430118

NCT00369317

NCT00002798

NCT00022126

NCT00016302

NCT00003593

Known as 6-thioguanine “Consolidation 6-thioguanine 60 mg/m2/d, 1 to 43 po; prednisone 40 mg/m2/d, on days 1-28 orally; vincristine 1.5 mg/m2/d, days 1, 8, 15, 22; idarubicin 7 mg/m2/d, on days 1, 8,...” NCT06211452
11

“The Children's Cancer Group 1952 (CCG-1952) clinical trial studied the substitution of oral 6-thioguanine (TG) for 6-mercaptopurine (MP) and triple intrathecal therapy (ITT)...” PMID 20124218 Feb 2010

“Maintenance therapy for one year with 6-thioguanine (100 mg/m2/d orally on days 1 through 4 every week)” NCT00925873

NCT02141100

NCT00199069

NCT00504660

NCT00587873

NCT00588536

NCT05276284

NCT00439296

NCT00184041

NCT00176462

Known as 6TG “2. 6-thioguanine (6TG) 12.5 mg/m2 orally taken once a day,” NCT05276284
Known as Lanvis ChEMBL registry synonym — accepted as the source's own label CHEMBL727
Known as NSC-752 ChEMBL registry synonym — accepted as the source's own label CHEMBL727
Known as NSC-76504 ChEMBL registry synonym — accepted as the source's own label CHEMBL727
Known as Tabloid “Thioguanine (Tabloid ®)” NCT06351306
Known as Thioguanine anhydrous ChEMBL registry synonym — accepted as the source's own label CHEMBL727
Known as Thioguanine hemihydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL727
Known as Tioguanin ClinicalTrials.gov intervention name — accepted as the source's own label NCT03643276
Known as Tioguanina ChEMBL registry synonym — accepted as the source's own label CHEMBL727
Known as Tioguanine ChEMBL registry synonym — accepted as the source's own label CHEMBL727
Known as Tioguanine hemihydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL727
Modality Other / unclassified “The thiopurines 6-mercaptopurine (6MP) and 6-thioguanine (6TG) are prodrugs” NCT05276284
Modality Small molecule CHEMBL727
Route Oral oral thioguanine on days 29-42” NCT00002514