Drugs / Thioguanine
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Thioguanine

Small molecule

Developed for
leukemia · lymphoblastic lymphoma · acute lymphoblastic leukemia · myelodysplastic syndrome · acute myeloid leukemia · B-cell childhood acute lymphoblastic leukemia · lymphoma · acute basophilic leukemia
+24 more · acute erythroid leukemia · acute leukemia · acute leukemia of ambiguous lineage · acute monocytic leukemia · acute myeloblastic leukemia with maturation · acute myeloblastic leukemia without maturation · acute myeloid leukemia with minimal differentiation · acute myelomonocytic leukemia M4 · adult acute lymphoblastic leukemia · B-cell acute lymphoblastic leukemia · B-lymphoblastic leukemia/lymphoma with hypodiploidy · B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) · brain neoplasm · childhood acute lymphoblastic leukemia · childhood acute megakaryoblastic leukemia · childhood acute myeloid leukemia · childhood myelodysplastic syndrome · lymphoid leukemia · mixed phenotype acute leukemia · myeloid leukemia associated with down syndrome · precursor B-cell acute lymphoblastic leukemia · T-cell acute lymphoblastic leukemia · urinary bladder cancer · urothelial carcinoma
Investigated by
National Cancer Institute (NCI) · Children's Oncology Group · Johann Wolfgang Goethe University Hospital · M.D. Anderson Cancer Center · Medical Research Council · SWOG Cancer Research Network
+24 more · Alliance for Clinical Trials in Oncology · Columbia University · Danish Child Cancer Foundation · Deutsche Krebshilfe e.V., Bonn (Germany) · GIMEMA Foundation · German Federal Ministry of Education and Research · Goethe University · Italian Association of Pediatric Hematology and Oncology · Jazz Pharmaceuticals · Kjeld Schmiegelow · Leukemia Research Fund · National University Hospital, Singapore · National University of Singapore · Nordic Society for Pediatric Hematology and Oncology · St. Jude Children's Research Hospital · Takeda · United Kingdom Children's Cancer Study Group · Universita degli Studi di Milano-Bicocca · University Hospital Muenster · University Hospital Schleswig-Holstein · University Hospital, Motol · University Medical Center Hamburg-Eppendorf · University of Michigan Rogel Cancer Center · University of Washington

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) THIOGUANINE — 1966-01-18 fda.gov ↗

Trials 40

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT00004056 Oct 1999 → Oct 2002 leukemia Children's Oncology Group Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT02912676 Oct 2016 → Mar 2020 acute lymphoblastic leukemia, lymphoblastic lymphoma Kjeld Schmiegelow Completed No outcome recorded
Phase 211 trials
Phase 2 NCT06351306 Apr 2024 acute myeloid leukemia Columbia University Withdrawn No outcome recorded Stop: Enrollment
Phase 2 NCT04845035 Jan 2024 → Jan 2026 acute lymphoblastic leukemia University of Michigan Rogel Cancer Center Withdrawn No outcome recorded
Phase 2 NCT02788201 Mar 2017 → Oct 2019 urinary bladder cancer, urothelial carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT02419469 Nov 2015 → Jun 2017 lymphoblastic lymphoma, precursor B-cell acute lymphoblastic leukemia M.D. Anderson Cancer Center Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT01451515 May 2012 → May 2021 lymphoblastic lymphoma St. Jude Children's Research Hospital Completed No outcome recorded
Phase 2 NCT00558519 Mar 2008 → Sep 2016 lymphoid leukemia Alliance for Clinical Trials in Oncology Completed No outcome recorded
Phase 2 NCT00866749 Sep 2006 → Jul 2018 lymphoblastic lymphoma M.D. Anderson Cancer Center Completed No outcome recorded
Phase 2 NCT00109837 Apr 2005 → Nov 2010 leukemia SWOG Cancer Research Network Completed No outcome recorded
Phase 2 NCT00003671 Dec 1998 → Nov 2002 leukemia Children's Oncology Group Completed No outcome recorded
Phase 2 NCT00002665 Jul 1995 → Dec 2001 leukemia, neutropenia, thrombocytopenia SWOG Cancer Research Network Completed No outcome recorded
Phase 321 trials · 3 missed
Phase 3 NCT03007147 Aug 2017 → Jun 2026 overdue B-cell acute lymphoblastic leukemia, T-cell acute lymphoblastic leukemia, mixed phenotype acute leukemia Children's Oncology Group Active not recruiting No outcome recorded
Phase 3 NCT02521493 Dec 2015 → Jun 2024 overdue Down syndrome, myelodysplastic syndrome, myeloid leukemia associated with down syndrome Children's Oncology Group Active not recruiting No outcome recorded
Phase 3 NCT01190930 Aug 2010 → Mar 2019 B-cell childhood acute lymphoblastic leukemia, B-lymphoblastic leukemia/lymphoma with hypodiploidy, B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2), Down syndrome +1 Children's Oncology Group Completed No outcome recorded
Phase 3 NCT00369317 Mar 2007 → Dec 2013 acute basophilic leukemia, acute erythroid leukemia, acute monocytic leukemia, acute myeloblastic leukemia with maturation +6 Children's Oncology Group Completed No outcome recorded
Phase 3 NCT00103285 Apr 2005 → Dec 2013 B-cell childhood acute lymphoblastic leukemia Children's Oncology Group Completed No outcome recorded
Phase 3 NCT00764907 Nov 2002 → Oct 2007 leukemia University Hospital, Motol Unknown No outcome recorded
Phase 3 NCT00613457 Sep 2000 → Jul 2006 leukemia Italian Association of Pediatric Hematology and Oncology Completed Missed primary
Phase 3 NCT00430118 Jul 2000 → Jan 2012 leukemia University Hospital Schleswig-Holstein Completed No outcome recorded
Phase 3 NCT00004228 Jun 2000 → Aug 2008 lymphoma Children's Oncology Group Completed Missed primary
Phase 3 NCT00005945 Jun 2000 → Nov 2007 leukemia Children's Oncology Group Completed Mixed
Phase 43 trials · 1 met primary
Phase 4 NCT02894645 Oct 2008 → Oct 2018 childhood acute lymphoblastic leukemia National University Hospital, Singapore Unknown Met primary
Phase 4 NCT00199017 Apr 2004 → Mar 2009 lymphoblastic lymphoma Johann Wolfgang Goethe University Hospital Completed No outcome recorded
Phase 4 NCT00199056 Oct 1999 → Nov 2003 adult acute lymphoblastic leukemia Goethe University Completed No outcome recorded
Phase not applicable3 trials
— NCT02551718 Sep 2015 → Jun 2020 acute leukemia of ambiguous lineage, acute lymphoblastic leukemia University of Washington Completed No outcome recorded
— NCT01156883 Apr 2010 → Oct 2017 leukemia GIMEMA Foundation Completed No outcome recorded
— NCT00343369 Jan 2003 → ? leukemia University Medical Center Hamburg-Eppendorf Unknown No outcome recorded
Comparator or background therapy44 trials
Phase 1 NCT03571321 Background May 2019 → Sep 2026 overdue childhood acute lymphoblastic leukemia University of Chicago Recruiting No outcome recorded
Phase 1 NCT00866307 Background Feb 2009 → Jun 2014 B-cell adult acute lymphocytic leukemia, B-cell childhood acute lymphoblastic leukemia Children's Oncology Group Completed No outcome recorded
Phase 2 NCT07636564 Background Oct 2026 → Apr 2031 expected B-cell acute lymphoblastic leukemia, T-cell acute lymphoblastic leukemia, acute leukemia of ambiguous lineage SWOG Cancer Research Network Not yet recruiting No outcome recorded
Phase 2 NCT06317662 Background Jun 2025 → Dec 2028 expected B-cell acute lymphoblastic leukemia, acute leukemia of ambiguous lineage National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 2 NCT06124157 Background May 2025 → Dec 2030 expected B-cell acute lymphoblastic leukemia National Cancer Institute (NCI) Recruiting No outcome recorded

Evidence & citations 13 cited values

Every value below carries the sentence it was read from. 86 sources stand behind the page.

FieldValueCited text
Known as thioguanine “with varied cycles, including Daunorubicin, Vincristine, Prednisone, Pegaspargase, Rituximab, Cytarabine, Mercaptopurine, Cyclophosphamide, Methotrexate, Doxorubicin,...” NCT04845035 ↗
83

“If participants are already using azathioprine or thioguanine, they will receive continued dosing 2-2.5mg/kg or 20mg once daily, respectively” NCT06059989 ↗

“Temsirolimus Thioguanine Topotecan HCl” NCT02551718 ↗

“Teniposide, Thioguanine, Thiotepa” NCT02788201 ↗

“Drug: Thioguanine” NCT03117751 ↗

“Thioguanine” NCT02665065 ↗

NCT00005596 ↗

NCT00002816 ↗

NCT00002514 ↗

NCT00109837 ↗

NCT02883049 ↗

Show 73 more sources

Known as 6-thioguanine “The Children's Cancer Group 1952 (CCG-1952) clinical trial studied the substitution of oral 6-thioguanine (TG) for 6-mercaptopurine (MP) and triple intrathecal therapy (ITT)...” PMID 20124218 ↗ Feb 2010
Known as Lanvis ChEMBL registry synonym — accepted as the source's own label CHEMBL727 ↗
Known as NSC-752 ChEMBL registry synonym — accepted as the source's own label CHEMBL727 ↗
Known as NSC-76504 ChEMBL registry synonym — accepted as the source's own label CHEMBL727 ↗
Known as Tabloid “Thioguanine (Tabloid ®)” NCT06351306 ↗
Known as Thioguanine anhydrous ChEMBL registry synonym — accepted as the source's own label CHEMBL727 ↗
Known as Thioguanine hemihydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL727 ↗
Known as Tioguanina ChEMBL registry synonym — accepted as the source's own label CHEMBL727 ↗
Known as Tioguanine ChEMBL registry synonym — accepted as the source's own label CHEMBL727 ↗
Known as Tioguanine hemihydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL727 ↗
Modality Small molecule — CHEMBL727 ↗
Route Oral “oral thioguanine on days 29-42” NCT00002514 ↗