drugset
drugset / Trial / NCT00002701

Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Promyelocytic Leukemia

NCT00002701 ↗

Phase 3 Unknown 750 enrolled European Organisation for Research and Treatment of Cancer - EORTC Gruppo Italiano Malattie EMatologiche dell'Adulto · collab
RandomizedTreatment

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Bone marrow transplantation may be able to replace immune cells that were destroyed by chemotherapy to kill tumor cells. It is not yet known which regimen of combination chemotherapy with or without bone marrow transplantation is more effective in treating promyelocytic leukemia PURPOSE: Randomized phase III trial to compare the effectiveness of different combination chemotherapy regimens with or without bone marrow transplantation in treating patients who have promyelocytic leukemia.

Timeline

Start
1995-10
Primary completion
—
Completion
—

Drugs

EvaluationDrugModalityDoseRoute
Subject Busulfan Small molecule — Oral
Subject MERCAPTOPURINE ANHYDROUS Small molecule — Oral
Subject Methotrexate Small molecule — Oral
Subject Tretinoin Small molecule — Oral
Background Cyclophosphamide Other / unclassified — Intravenous
Background Cytarabine Small molecule — Intravenous
Background Etoposide Small molecule — Intravenous
Background Idarubicin Small molecule — Intravenous
Background Mitoxantrone Small molecule — Intravenous
Background Thioguanine Small molecule — Oral

Indications

leukemia