drugset
drugset / Trial / NCT00004056

Combination Chemotherapy Followed by Melphalan and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Acute Myeloid Leukemia

NCT00004056 ↗

Phase 1 Completed 35 enrolled Children's Oncology Group National Cancer Institute (NCI) · collab
NaSingle-groupOpen-labelTreatment

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow doctors to give higher doses of chemotherapy drugs and kill more cancer cells. PURPOSE: Phase I trial to study the effectiveness of combination chemotherapy followed by melphalan and peripheral stem cell transplantation in treating children who have newly diagnosed acute myeloid leukemia that has not been treated previously.

Timeline

Start
1999-10
Primary completion
2002-10
Completion
2007-03

Publications

  • Results Hurwitz CA, Chang M, Graham M, et al.: Timed-sequential remission induction and intensification followed by stem cell rescue for childhood AML -a POG pilot study. [Abstract] Proceedings of the American Society of Clinical Oncology 21: A-1553, 2002.

Drugs

EvaluationDrugModalityDoseRoute
Subject Cytarabine Small molecule — Intravenous
Subject Daunorubicin Small molecule — Intravenous
Subject Melphalan Small molecule — Intravenous
Subject Thioguanine Small molecule — Oral
Subject asparaginase Protein / enzyme biologic — —
Background filgrastim Protein / enzyme biologic — Intravenous

Indications

leukemia