Drugs / Azacitidine
last change 7 days ago re-read 8 days ago

Azacitidine

also known as AZA · 5-azacitidine · Vidaza · CC-486 · 5-azacytidine · 5-aza · azacytidine · Onureg · +14 more

Other / unclassified

Developed for
acute myeloid leukemia · myelodysplastic syndrome · chronic myelomonocytic leukemia · leukemia · peripheral T-cell lymphoma, not otherwise specified · non-small cell lung carcinoma · acute lymphoblastic leukemia · plasma cell myeloma
+154 more · therapy related acute myeloid leukemia and myelodysplastic syndrome · angioimmunoblastic T-cell lymphoma · disease related to hematopoietic stem cell transplant · diffuse large B-cell lymphoma · Hodgkins lymphoma · myeloid neoplasm · acute megakaryoblastic leukemia in adult · acute myeloblastic leukemia with maturation · acute myeloblastic leukemia without maturation · acute myeloid leukemia with t(8;21)(q22;q22) translocation · acute myeloid leukemia, inv(16)(p13.1;q22) · acute myeloid leukemia, t(16;16)(p13.1;q22) · acute myelomonocytic leukemia M4 · adult acute monocytic leukemia · mixed phenotype acute leukemia · myelodysplastic syndrome with excess blasts · myelofibrosis · non-Hodgkin lymphoma · acute biphenotypic leukemia · acute myeloid leukemia with 11q23 abnormalities · acute myeloid leukemia with multilineage dysplasia · colorectal cancer · erythroleukemia · juvenile myelomonocytic leukemia · myelodysplastic/myeloproliferative neoplasm · myeloproliferative neoplasm · prostate cancer · T-cell acute lymphoblastic leukemia · T-cell non-Hodgkin lymphoma · acute erythroid leukemia · acute leukemia of ambiguous lineage · acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent · acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) · acute myeloid leukemia with minimal differentiation · acute myeloid leukemia with mutated NPM1 · acute myeloid leukemia, FLT3 internal tandem duplication · acute myeloid leukemia, t(8;21)(q22; q22.1) · acute myeloid leukemia, t(9;11)(p21.3;q23.3) · adult T-cell leukemia/lymphoma · anaplastic large cell lymphoma · bilineal acute myeloid leukemia · cancer · chronic lymphocytic leukemia/small lymphocytic lymphoma · follicular lymphoma · hematopoietic and lymphoid cell neoplasm · lymphoma · monomorphic epitheliotropic intestinal T-cell lymphoma · myelodysplastic/myeloproliferative disease · Nodal T-follicular helper cell lymphoma, follicular type · primary myelofibrosis · acquired polycythemia vera · acute monocytic leukemia · acute myeloid leukemia with t(9;11)(p22;q23) · acute promyelocytic leukemia · atypical chronic myeloid leukemia, BCR-ABL1 negative · B-cell acute lymphoblastic leukemia · B-cell non-Hodgkin lymphoma · blast phase chronic myelogenous leukemia, BCR-ABL1 positive · breast cancer · cancer of unknown primary site · cerebral palsy · childhood acute myeloid leukemia · chronic myeloid leukemia · classic Hodgkin lymphoma · enteropathy-associated T-cell lymphoma · essential thrombocythemia · extranodal nasal NK/T cell lymphoma · female breast carcinoma · head and neck cancer · hepatosplenic T-cell lymphoma · lymphoplasmacytic lymphoma · malignant pancreatic neoplasm · mature T-cell and NK-cell non-Hodgkin lymphoma · myelodysplastic syndrome with excess blasts-2 · myeloproliferative neoplasm, unclassifiable · T-cell large granular lymphocyte leukemia · triple-negative breast carcinoma · acute basophilic leukemia · acute kidney injury · acute leukemia · acute megakaryoblastic leukemia · acute myeloid leukemia, CEBPA gene mutation · acute myeloid leukemia, del(5q31-q32) · acute myeloid leukemia, FLT3 tyrosine kinase domain point mutation · acute undifferentiated leukemia · astrocytoma, IDH-mutant, grade 4 · autoimmune disease · B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) · cardia cancer · CD4+/CD56+ hematodermic neoplasm · childhood myelodysplastic syndrome · colorectal carcinoma · cutaneous melanoma · diffuse glioma, H3 G34 mutant · diffuse large B-cell lymphoma activated B-cell type · diffuse large B-cell lymphoma germinal center B-cell type · diffuse large B-cell lymphoma with chronic inflammation · digestive system cancer · early T cell progenitor acute lymphoblastic leukemia · esophageal cancer · estrogen-receptor positive breast cancer · glioma · gliosarcoma · graft versus host disease · hairy cell leukemia · head and neck squamous cell carcinoma · high grade B-cell lymphoma · high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement · intravascular large B-cell lymphoma · invasive breast carcinoma · leukemia, myeloid, accelerated-phase · lung cancer · lymphoblastic lymphoma · male breast carcinoma · MALT lymphoma · mantle cell lymphoma · marginal zone lymphoma · mesothelioma · metastatic malignant neoplasm · metastatic melanoma · metastatic neoplasm · mixed phenotype acute leukemia,T/myeloid · mycosis fungoides and variants · myelodysplastic syndrome associated with isolated del(5q) · myelodysplastic syndrome with excess blasts-1 · myelodysplastic syndrome with ring sideroblasts · myeloid sarcoma · nasopharyngeal squamous cell carcinoma · ovarian cancer · pancreatic ductal adenocarcinoma · Philadelphia-positive myelogenous leukemia · post-transplant lymphoproliferative disease · precursor lymphoblastic lymphoma/leukemia · premalignant hematological system disease · primary cutaneous diffuse large B-cell lymphoma, Leg type · primary thrombocytopenia · prolymphocytic leukemia · pulmonary tuberculosis · rectal cancer · refractory malignant neoplasm · refractory plasma cell neoplasm · renal cell carcinoma · skin cancer · small intestine cancer · small intestine lymphoma · soft tissue sarcoma · squamous cell carcinoma · systemic mastocytosis · T-cell/histiocyte rich large B cell lymphoma · undifferentiated carcinoma of nasopharynx · urinary bladder cancer · urothelial carcinoma · virus associated tumor · osteosarcoma
Investigated by
National Cancer Institute (NCI) · Celgene Corporation · M.D. Anderson Cancer Center · The First Affiliated Hospital of Soochow University · AbbVie · Institute of Hematology & Blood Diseases Hospital, China
+413 more · Bristol-Myers Squibb · Groupe Francophone des Myelodysplasies · Ruijin Hospital · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Millennium Pharmaceuticals, Inc. · Merck Sharp & Dohme LLC · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington University School of Medicine · Beijing 302 Hospital · Memorial Sloan Kettering Cancer Center · Nanfang Hospital, Southern Medical University · Technical University Dresden · The First Affiliated Hospital of Xiamen University · Aprea Therapeutics · City of Hope Medical Center · Genentech, Inc. · Huizhou Municipal Central Hospital · Incyte Corporation · Peking Union Medical College Hospital · Pfizer · Suzhou Hospital of Traditional Chinese Medicine · The Second People's Hospital of Huai'an · University of Colorado, Denver · Affiliated Hospital of Nantong University · Dongguan People's Hospital · First Affiliated Hospital of Zhejiang University · Fred Hutchinson Cancer Center · H. Lee Moffitt Cancer Center and Research Institute · Janssen Research & Development, LLC · Jining Medical University · Novartis Pharmaceuticals · Oregon Health and Science University · Stemline Therapeutics, Inc. · Sun Yat-sen University · The First Affiliated Hospital of Bengbu Medical University · The First Affiliated Hospital with Nanjing Medical University · Amgen · Assistance Publique - Hôpitaux de Paris · AstraZeneca · CTI BioPharma · Canglang Hospital of Suzhou · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Fujian Cancer Hospital · Fujian Provincial Hospital · GIMEMA Foundation · Guangdong Second Provincial General Hospital · Guangzhou First People's Hospital · Jieyang People's Hospital · Jinhua Central Hospital · Karolinska University Hospital · Mirati Therapeutics Inc. · Northern Jiangsu People's Hospital · OHSU Knight Cancer Institute · PETHEMA Foundation · Shenzhen Second People's Hospital · St. Jude Children's Research Hospital · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Syndax Pharmaceuticals · Uma Borate · University of Southern California · Acute Leukemia French Association · Ascentage Pharma Group Inc. · Astellas Pharma Global Development, Inc. · Boehringer Ingelheim · Brian Jonas · Case Comprehensive Cancer Center · Chinese Academy of Medical Sciences · Chipscreen Biosciences, Ltd. · Columbia University · First Affiliated Hospital of Guangxi Medical University · French Innovative Leukemia Organisation · GWT-TUD GmbH · Ge Zheng · Guangdong Provincial People's Hospital · all 419 on the full record

Regulatory milestones approvals, filings & regulatory actions · 6 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) ONUREG — 2026-04-09 fda.gov ↗
Label expansions (3) US (FDA) VIDAZA — 2007-01-26 – 2022-05-20 fda.gov ↗
Approved EU (EMA) Vidaza — 2008-12-17 europa.eu ↗
Approved US (FDA) VIDAZA — 2004-05-19 fda.gov ↗

Trials 533 · started per year

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EU approved 2008
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT07598578 Jun 2026 → Jan 2030 expected peripheral T-cell lymphoma, not otherwise specified Second Affiliated Hospital of Soochow University Recruiting No outcome recorded
Phase 0 NCT04518345 Nov 2020 → Oct 2021 therapy related acute myeloid leukemia and myelodysplastic syndrome Uma Borate Completed No outcome recorded
Phase 1119 trials · 1 met primary
Phase 1 NCT07691450 Jan 2027 → Nov 2029 expected Nodal T-follicular helper cell lymphoma, follicular type, anaplastic large cell lymphoma, angioimmunoblastic T-cell lymphoma, enteropathy-associated T-cell lymphoma +6 City of Hope Medical Center Not yet recruiting No outcome recorded
Phase 1 NCT07828535 Oct 2026 → Dec 2027 expected acute myeloid leukemia Institute of Hematology & Blood Diseases Hospital, China Not yet recruiting No outcome recorded
Phase 1 NCT07645469 Oct 2026 → Jul 2030 expected acute myeloid leukemia Fred Hutchinson Cancer Center Recruiting No outcome recorded
Phase 1 NCT07679334 Aug 2026 → Aug 2028 expected myeloproliferative neoplasm Roswell Park Cancer Institute Not yet recruiting No outcome recorded
Phase 1 NCT07548983 Apr 2026 → Dec 2027 expected acute myeloid leukemia OHSU Knight Cancer Institute Recruiting No outcome recorded
Phase 1 NCT07388563 Mar 2026 → Mar 2027 expected adult T-cell leukemia/lymphoma, anaplastic large cell lymphoma, angioimmunoblastic T-cell lymphoma, monomorphic epitheliotropic intestinal T-cell lymphoma +1 National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1 NCT07404332 Feb 2026 → Feb 2028 expected cancer, metastatic neoplasm Mohammed Milhem Recruiting No outcome recorded
Phase 1 NCT07303660 Nov 2025 → Dec 2026 expected acute myeloid leukemia Lomond Therapeutics Holdings, Inc. Recruiting No outcome recorded
Phase 1 NCT06896110 Jun 2025 → Mar 2027 expected astrocytoma, IDH-mutant, grade 4, diffuse glioma, H3 G34 mutant, gliosarcoma Andrew P. Groves Enrolling by invitation No outcome recorded
Phase 1 NCT07094464 Jun 2025 → Jun 2027 expected acute myeloid leukemia, disease related to hematopoietic stem cell transplant Daihong Liu Active not recruiting No outcome recorded
Show all 119 trials opens the full record — a long page
Phase 1/296 trials
Phase 1/2 NCT07706959 Jul 2026 → Jan 2028 expected peripheral T-cell lymphoma, not otherwise specified Ruijin Hospital Not yet recruiting No outcome recorded
Phase 1/2 NCT07387354 Jul 2026 → Jan 2027 expected myelodysplastic syndrome, myeloproliferative neoplasm Thomas Jefferson University Not yet recruiting No outcome recorded
Phase 1/2 NCT07508982 May 2026 → Dec 2029 expected acute myeloid leukemia M.D. Anderson Cancer Center Recruiting No outcome recorded
Phase 1/2 NCT07493330 Mar 2026 → Dec 2029 expected refractory malignant neoplasm Ruijin Hospital Not yet recruiting No outcome recorded
Phase 1/2 NCT07148180 Feb 2026 → Dec 2028 expected acute myeloid leukemia Jacqueline Garcia, MD Recruiting No outcome recorded
Phase 1/2 NCT06611839 Oct 2025 → Oct 2026 expected acute myeloid leukemia Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded
Phase 1/2 NCT07451912 Sep 2025 → Sep 2027 expected acute myeloid leukemia, CEBPA gene mutation The First Affiliated Hospital of Soochow University Recruiting No outcome recorded
Phase 1/2 NCT07018752 Aug 2025 → Apr 2028 expected peripheral T-cell lymphoma, not otherwise specified The Lymphoma Academic Research Organisation Recruiting No outcome recorded
Phase 1/2 NCT06548230 Mar 2025 → Dec 2027 expected acute myeloid leukemia, myelodysplastic syndrome M.D. Anderson Cancer Center Recruiting No outcome recorded
Phase 1/2 NCT06757855 Jan 2025 → Dec 2026 expected blast phase chronic myelogenous leukemia, BCR-ABL1 positive Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded
Phase 2232 trials · 3 met primary · 4 missed
Phase 2 NCT07862517 Jan → Dec 2027 expected acute myeloid leukemia National Cancer Institute (NCI) Not yet recruiting No outcome recorded
Phase 2 NCT05554419 Jan 2027 → Dec 2030 expected therapy related acute myeloid leukemia and myelodysplastic syndrome National Cancer Institute (NCI) Not yet recruiting No outcome recorded
Phase 2 NCT07605949 Oct 2026 → Jul 2028 expected acute myeloid leukemia UNC Lineberger Comprehensive Cancer Center Not yet recruiting No outcome recorded
Phase 2 NCT07813390 Sep 2026 → Sep 2027 expected acute myeloid leukemia Guangdong Second Provincial General Hospital Enrolling by invitation No outcome recorded
Phase 2 NCT07755202 Sep 2026 → Oct 2029 expected acute myeloid leukemia Florian Kuchenbauer Not yet recruiting No outcome recorded
Phase 2 NCT07471841 Sep 2026 → Jun 2028 expected acute myeloid leukemia Timothy Pardee Recruiting No outcome recorded
Phase 2 NCT06903702 Aug 2026 → Jun 2027 expected acute myeloid leukemia Memorial Sloan Kettering Cancer Center Not yet recruiting No outcome recorded
Phase 2 NCT07664839 Jul 2026 → May 2028 expected acute myeloid leukemia with mutated NPM1 Shen yang Not yet recruiting No outcome recorded
Phase 2 NCT07643636 Jun 2026 → Jun 2028 expected acute myeloid leukemia Dongguan People's Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07672262 Jun 2026 → Jun 2030 expected acute myeloid leukemia The First Affiliated Hospital of Soochow University Recruiting No outcome recorded
Show all 232 trials opens the full record — a long page
Phase 2/313 trials
Phase 2/3 NCT07425808 Dec 2026 → Oct 2028 expected acute myeloid leukemia European Organisation for Research and Treatment of Cancer - EORTC Not yet recruiting No outcome recorded
Phase 2/3 NCT07583888 May 2026 → Aug 2027 expected acute myeloid leukemia, disease related to hematopoietic stem cell transplant The First Affiliated Hospital of Soochow University Recruiting No outcome recorded
Phase 2/3 NCT07651163 Mar 2026 → Dec 2029 expected acute myeloid leukemia First Affiliated Hospital of Zhejiang University Enrolling by invitation No outcome recorded
Phase 2/3 NCT07389616 Feb 2026 → Feb 2028 expected peripheral T-cell lymphoma, not otherwise specified Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Recruiting No outcome recorded
Phase 2/3 NCT05469737 Dec 2022 → Jul 2028 expected myelodysplastic syndrome Bristol-Myers Squibb Active not recruiting No outcome recorded
Phase 2/3 NCT05404906 Jun 2022 → Jun 2028 expected acute myeloid leukemia The First Affiliated Hospital of Soochow University Recruiting No outcome recorded
Phase 2/3 NCT04799275 May 2021 → Mar 2027 expected T-cell/histiocyte rich large B cell lymphoma, diffuse large B-cell lymphoma activated B-cell type, diffuse large B-cell lymphoma germinal center B-cell type, diffuse large B-cell lymphoma with chronic inflammation +5 National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 2/3 NCT05175508 May 2021 → May 2022 acute myeloid leukemia, myelodysplastic syndrome The First Affiliated Hospital of Soochow University Unknown No outcome recorded
Phase 2/3 NCT04256317 May 2020 → Nov 2027 expected acute myeloid leukemia, chronic myelomonocytic leukemia, myelodysplastic syndrome Taiho Oncology, Inc. Recruiting No outcome recorded
Phase 2/3 NCT04216355 Jan 2020 → Dec 2021 myelodysplastic syndrome with excess blasts Fujian Medical University Unknown No outcome recorded
Phase 338 trials · 2 met primary · 8 missed
Phase 3 NCT07686965 Aug 2026 → Aug 2030 expected acute myeloid leukemia Institute of Hematology & Blood Diseases Hospital, China Not yet recruiting No outcome recorded
Phase 3 NCT07407140 Apr 2026 → Feb 2029 expected acute myeloid leukemia Institute of Hematology & Blood Diseases Hospital, China Not yet recruiting No outcome recorded
Phase 3 NCT07539818 Apr 2026 → Apr 2030 expected acute myeloid leukemia Institute of Hematology & Blood Diseases Hospital, China Not yet recruiting No outcome recorded
Phase 3 NCT07469046 Apr 2026 → Mar 2028 expected acute myeloid leukemia Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Not yet recruiting No outcome recorded
Phase 3 NCT07486479 Mar → Dec 2026 expected acute myeloid leukemia The First Affiliated Hospital of Soochow University Not yet recruiting No outcome recorded
Phase 3 NCT07407660 Feb 2026 → Feb 2028 expected acute myeloid leukemia Peking University People's Hospital Not yet recruiting No outcome recorded
Phase 3 NCT07132684 Aug 2025 → Aug 2027 expected acute myeloid leukemia Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded
Phase 3 NCT06852222 Jun 2025 → Jun 2029 expected acute myeloid leukemia Janssen Research & Development, LLC Recruiting No outcome recorded
Phase 3 NCT06927232 Apr 2025 → Jan 2026 overdue myelodysplastic syndrome Peking Union Medical College Hospital Not yet recruiting No outcome recorded
Phase 3 NCT06713837 Feb 2025 → Jan 2028 expected acute myeloid leukemia Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS Recruiting No outcome recorded
Phase 45 trials
Phase 4 NCT07044687 Jul 2025 → Nov 2027 expected acute myeloid leukemia AbbVie Recruiting No outcome recorded
Phase 4 NCT06370000 Nov 2024 → Jan 2027 expected acute myeloid leukemia Virginia Commonwealth University Recruiting No outcome recorded
Phase 4 NCT06004765 Aug 2023 → Aug 2024 myelodysplastic syndrome Peking Union Medical College Hospital Unknown No outcome recorded
Phase 4 NCT05144243 Jan 2022 → Mar 2026 overdue acute myeloid leukemia AbbVie Active not recruiting No outcome recorded
Phase 4 NCT01201811 Oct 2010 → May 2013 myelodysplastic syndrome Celgene Corporation Completed No outcome recorded
Phase not applicable28 trials
— NCT07632170 Nov 2026 → Oct 2027 expected myeloid neoplasm Bing Han Not yet recruiting No outcome recorded
— NCT07635485 Jun 2026 → May 2029 expected acute myeloid leukemia The First Affiliated Hospital of Soochow University Not yet recruiting No outcome recorded
— NCT07521124 Jun 2026 → Jun 2029 expected acute myeloid leukemia Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Not yet recruiting No outcome recorded
— NCT07542912 Jun 2026 → Jun 2029 expected — Sun Yat-sen University Not yet recruiting No outcome recorded
— NCT07490288 May → Jul 2026 overdue acute myeloid leukemia Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded
— NCT06572982 Apr 2025 → May 2026 overdue acute myeloid leukemia Hikma Pharmaceuticals LLC Active not recruiting No outcome recorded
— NCT06841952 Feb 2025 → Dec 2028 expected acute myeloid leukemia The First Affiliated Hospital of Soochow University Not yet recruiting No outcome recorded
— NCT07236931 Jan 2025 → May 2026 acute myeloid leukemia Donghua Zhang Completed No outcome recorded
— NCT06386302 Aug 2024 → Dec 2027 expected acute myeloid leukemia Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded
— NCT07131059 May 2024 → May 2026 overdue acute myeloid leukemia Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded
Comparator or background therapy186 trials
Phase 0 NCT07071155 Background Mar 2026 → Mar 2028 expected chronic myelomonocytic leukemia, chronic neutrophilic leukemia, myelodysplastic syndrome Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting No outcome recorded
Phase 1 NCT07439211 Background Jul 2026 → Feb 2028 expected acute myeloid leukemia Jacqueline Garcia, MD Not yet recruiting No outcome recorded
Phase 1 NCT07177079 Background Mar 2026 → Dec 2028 expected acute myeloid leukemia Kittika Poonsombudlert Recruiting No outcome recorded
Phase 1 NCT07320235 Comparator Jan 2026 → Jun 2030 expected acute myeloid leukemia Douglas Tremblay Recruiting No outcome recorded
Phase 1 NCT07014462 Background Sep 2025 → Jun 2029 expected acute myeloid leukemia University of Vermont Enrolling by invitation No outcome recorded
Show all 186 trials opens the full record — a long page

Press releases naming this drug 59 releases

DateIssuerRelease
2026-10-01 Taiho Oncology, Inc. Taiho Pharmaceutical and Taiho Oncology Announce Positive Topline Results in Phase 3 AZTOUND Trial Evaluating Oral Azacitidine and Cedazuridine in Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia taiho.co.jp ↗
2026-09-30 Taiho Oncology, Inc. Taiho Oncology and Taiho Pharmaceutical Announce Positive Topline Results in Phase 3 AZTOUND Trial Evaluating Oral Azacitidine and Cedazuridine in Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia taihooncology.com ↗
2026-06-03 Kyowa Kirin, Inc. Kura Oncology and Kyowa Kirin Announce Publication in Blood of Ziftomenib plus Venetoclax / Azacitidine Combination in Patients with R/R NPM1-m AML – 87% ORR and 70% CRc in venetoclax-naïve and 48% ORR and 24% CRc in venetoclax-experienced patients at the recommended 600 mg once-daily dose – – Central MRD negativity in 75% of CRc responders with no prior venetoclax exposure; median CRc duration was 9.2 months – – Median OS not reached after median follow up of 10.7 months in patients with no prior venetoclax exposure – – Combination was well tolerated, with low rates of differentiation syndrome and QTc prolongation observed – kyowakirin.com ↗
2026-06-02 Kura Oncology, Inc. Kura Oncology and Kyowa Kirin Announce Publication in Blood of Ziftomenib plus Venetoclax / Azacitidine Combination in Patients with R/R NPM1-m AML kuraoncology.com ↗
2025-12-08 Taiho Oncology, Inc. Taiho Oncology Presents Data on All-Oral Regimens Azacitidine and Cedazuridine, and Decitabine and Cedazuridine at the 2025 American Society of Hematology Annual Meeting and Exposition taihooncology.com ↗
2025-12-08 Kura Oncology, Inc. Kura Oncology and Kyowa Kirin Report Combination Data for KOMZIFTI™ (Ziftomenib) with Venetoclax and Azacitidine in Newly Diagnosed and Relapsed/Refractory AML kuraoncology.com ↗
2025-12-03 Kura Oncology, Inc. Kura Oncology to Host Virtual Investor Event to Discuss Data Presented at ASH 2025 on Triplet Combination of Ziftomenib (KOMZIFTI®) with Venetoclax and Azacitidine in Newly Diagnosed and Relapsed/Refractory Acute Myeloid Leukemia kuraoncology.com ↗
2025-11-03 Sellas Life Sciences Group SELLAS Life Sciences Announces Presentation of Phase 2 Data of SLS009 in Combination with Azacitidine and Venetoclax in Relapsed/Refractory AML with MDS-Related Changes (AML-MR) at the 2025 American Society of Hematology (ASH) Annual Meeting sellaslifesciences.com ↗
2025-06-12 Janssen Research & Development, LLC New results for Johnson & Johnson’s bleximenib demonstrate promising antileukemic activity in combination with venetoclax and azacitidine for acute myeloid leukemia jnj.com ↗
2025-06-12 Janssen Research & Development, LLC New results for Johnson & Johnson's bleximenib demonstrate promising antileukemic activity in combination with venetoclax and azacitidine for acute myeloid leukemia jnj.com ↗
2025-01-13 Oryzon Genomics S.A. ORYZON announces first patient dosed in NCI-sponsored iadademstat in combination with venetoclax and azacitidine clinical trial in first line acute myeloid leukemia oryzon.com ↗
2024-06-14 Shattuck Labs, Inc. Shattuck Labs Announces Updated Positive Interim Data from the Phase 1B Dose Expansion Clinical Trial of SL-172154 in Combination with Azacitidine (AZA) in Frontline Higher-Risk Myelodysplastic Syndromes (HR-MDS) and TP53 mutant (TP53m) Acute Myeloid Leukemia (AML) Patients shattucklabs.com ↗

Evidence & citations 26 cited values

Every value below carries the sentence it was read from. 733 sources stand behind the page.

FieldValueCited text
Known as Azacitidine “Eligible subjects with NPM1 MRD positivity will receive oral arsenic trioxide (oral-As2O3) (Arsenol ®) (5-10mg per day, from days 1-7 per cycle), ascorbic acid (1g per day,...” NCT04689815 ↗
694

“This is a multicenter, nonrandomized, open-label phase 2 study (with a safety run-in phase) of azacitidine (AZA) 75 mg/m2 given IV or SQ on days 1-7 every 28 days in...” NCT02845297 ↗

“Participants will receive standard low-intensity therapy (LIT) regimens for newly diagnosed AML, which may include venetoclax combined with either azacitidine, decitabine, or...” NCT07014462 ↗

“A Single-arm, Single-center Clinical Trial Evaluating the Efficacy and Safety of a Regimen Combining Chidamide With Venetoclax, Azacitidine, and Homoharringtonine in the...” NCT07643636 ↗

“Each 28-day cycle is comprised of Pevonedistat at 20 mg/m2 IV infusion over 1 hour on days 1, 3 and 5 and Azacitidine at 25 mg/m2 IV infusion over 30 minutes on days 1, 2, 3,...” NCT03709576 ↗

“Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of abnormal cells, either by killing the cells or by stopping them from dividing.” NCT00398047 ↗

“Onureg (CC-486, oral azacitidine) will be administered orally at 200 or 300 mg once daily for 7 or 14 consecutive days, beginning on Day 1 of repeated 28-day cycles.” NCT05782127 ↗

“Azacitidine 75 mg/m2 Subcutaneous (SC) or IV Daily with a continuous 7-day scheme or on a 5-on/2-off [weekend]/2-on schedule (5-0-2) in 28-day cycle” NCT07082452 ↗

“Drug: Azacitidine Tablets or capsules for oral administration and powder for reconstitution to aqueous suspension for subcutaneous administration” NCT04608110 ↗

“Azacitidine (5-azacytidine) is a nucleoside metabolic inhibitor that has been US Food and Drug Administration-approved for several MDS subtypes.” NCT04609826 ↗

“Azacitidine +Selinexor ± venetoclax were administered (Selinexor: 60mg/ week, qw*4 weeks; azacitidine: 100mg/m2*d1-d7; venetoclax, 100mg d1-14).” NCT07632170 ↗

Show 684 more sources

Known as 5'-azacitadine “5'-azacitadine will be given at a low dose of 32mg/m2 S.C for 5 days every 28 days (a cycle).” NCT01995578 ↗
Known as 5-aza “participants with recurrent and/or metastatic (R/M) HNSCC were treated with low-dose 5-azacytidine (5-aza) daily for either 5 or 10 days in combination with durvalumab and...” PMID 40091844 ↗ Mar 2025
4

“The BCL2 inhibitor venetoclax (VEN) in combination with azacitidine (5-AZA) is currently transforming acute myeloid leukemia (AML) therapy.” PMID 36892565 ↗ Jun 2023

“the deoxyribonucleic acid (DNA) methyltransferase inhibitor, 5-azacitidine (5-AZA)” NCT01207726 ↗

“5-Azacitidine (5 AZA) in subjects with myelodysplastic syndrome (MDS)” NCT01828346 ↗

“5-Azacitidine(5-AZA) is the most promising drug for treatment MDSs.” NCT00897130 ↗

Known as 5-azacitidine “To investigate its mechanism of action, we performed integrative expression and methylation analysis of 63 cancer cell lines (breast, colorectal, and ovarian) after treatment...” PMID 24583822 ↗ Feb 2014
23

“The purpose of this study is to learn if 5'-Azacitidine will help to lower the risk of the disease coming back after a stem cell transplant in patients with MDS and AML.” NCT01995578 ↗

“Treatment of Imminent Haematological Relapse in Patients With AML and MDS Following Allogeneic Stem Cell Transplantation With 5-azacitidine (Vidaza®)” NCT00422890 ↗

“Demethylation drugs, such as 5-azacitidine (AZA) and 5-aza-2-deoxycytidine (decitabine), can inhibit DNA methyltransferase” NCT03978364 ↗

“the deoxyribonucleic acid (DNA) methyltransferase inhibitor, 5-azacitidine (5-AZA)” NCT01207726 ↗

“5-Azacitidine (Azacitidine) is a nucleoside analogue chemotherapy drug” NCT07404332 ↗

“5-Azacitidine(5-AZA) is the most promising drug for treatment MDSs.” NCT00897130 ↗

NCT00766116 ↗

NCT00660400 ↗

NCT05675813 ↗

NCT03572387 ↗

Show 13 more sources

Known as 5-Azacytidin ClinicalTrials.gov intervention name — accepted as the source's own label NCT00422890 ↗
Known as 5-azacytidine “The goal of this clinical research study is to find the highest tolerable dose of Azacytidine (5-azacytidine) combined with cytosine arabinoside (ara-C) for the treatment of...” NCT00569010 ↗
5

“participants with recurrent and/or metastatic (R/M) HNSCC were treated with low-dose 5-azacytidine (5-aza) daily for either 5 or 10 days in combination with durvalumab and...” PMID 40091844 ↗ Mar 2025

“Drug2: Azacitidine (5-azacytidine) is a cytidine nucleoside analogue that selectively inhibits DeoxyriboNucleic Acid methyltransferases at low doses, resulting in gene promoter...” NCT05426798 ↗

“Azacitidine (5-azacytidine) is a nucleoside metabolic inhibitor that has been US Food and Drug Administration-approved for several MDS subtypes.” NCT04609826 ↗

“5-Azacytidine is designed to activate ("turn on") certain genes in cancer cells whose job is to fight tumors.” NCT01254890 ↗

“The hypomethylating agent azacitidine (also known as 5-azacytidine or Vidaza®).” NCT02750995 ↗

Known as 5-AZC “5-AZC” NCT01168219 ↗
Known as AZA “This study is a prospective, single-center, single-arm clinical study, which plans to enroll 40 patients with high-risk myelodysplastic syndrome (MDS) to be given azacitidine...” NCT06279338 ↗
69

“Herein, we present the phase 1a dose escalation data of IO-202 as monotherapy and in combination with azacitidine (AZA) in patients with relapsed/refractory (R/R) acute myeloid...” PMID 40919482 ↗ Jun 2025

“In this phase 1 study, azacitidine (AZA) was given before high-dose cytarabine (HiDAC) and mitoxantrone (mito) based on the hypothesis that epigenetic priming with a...” PMID 32074275 ↗ Feb 2020

“This research is being done to study the efficacy and safety of unrelated umbilical cord blood stem cell microtransplantation combined with azacitidine(AZA) based treatment for...” NCT05584761 ↗

“This single arm, prospective study on the feasibility of a bridging treatment with low-dose azacitidine (AZA) in combination with short term CAG derived regimen prior to...” NCT04216355 ↗

“This is a multicenter, nonrandomized, open-label phase 2 study (with a safety run-in phase) of azacitidine (AZA) 75 mg/m2 given IV or SQ on days 1-7 every 28 days in...” NCT02845297 ↗

“Based on the efficacy data of venetoclax (VEN)-based treatment in NPM1mut AML older patients, we retrospectively analysed the off-label combination of VEN plus azacitidine...” PMID 37226312 ↗ May 2023

“This study will assess the adverse events and changes in the disease activity when Pivekimab Sunirine (PVEK) is given in combination with Venetoclax (VEN) and Azacitidene (AZA)...” NCT07581002 ↗

“To investigate its mechanism of action, we performed integrative expression and methylation analysis of 63 cancer cell lines (breast, colorectal, and ovarian) after treatment...” PMID 24583822 ↗ Feb 2014

“We designed a phase 1/2 clinical trial to examine the safety/efficacy of the protein synthesis inhibitor omacetaxine mepesuccinate (oma) with the hypomethylating agent (HMA)...” PMID 41140451 ↗ Oct 2025

“a novel biomodulatory treatment regimen consisting of low-dose azacitidine (AZA) in combination with PPARγ agonist pioglitazone (PGZ) and all-trans retinoic acid (ATRA) induced...” PMID 30542286 ↗ Nov 2018

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Known as Azacitadine (AZA) “Drug: Azacitadine (AZA)” NCT06561880 ↗
Known as Azacitidene “This study will assess the adverse events and changes in the disease activity when Pivekimab Sunirine (PVEK) is given in combination with Venetoclax (VEN) and Azacitidene (AZA)...” NCT07581002 ↗
Known as azacitidin “decitabine or azacitidin (AZA), producing complete remission (CR) plus CR with incomplete hematologic recovery (CRi) rates of 74% and 66.7%, respectively, in previously...” NCT04824924 ↗
Known as Azacitidine (5-Azacytidine, Ladakamycin) “Azacitidine (5-Azacytidine, Ladakamycin)” NCT05362942 ↗
Known as Azacitidine (AZA) “Azacitidine (AZA)” NCT05061147 ↗
Known as Azacitidine (Vidaza) “Azacitidine (Vidaza)” NCT01748240 ↗
Known as Azacitidine = Vidaza (Celgene) “Azacitidine = Vidaza® (Celgene)” NCT01324960 ↗
Known as azacytidine “The goal of this clinical research study is to find the highest tolerable dose of Azacytidine (5-azacytidine) combined with cytosine arabinoside (ara-C) for the treatment of...” NCT00569010 ↗
3

“Hypomethylating agents (HMA) like azacytidine (AZA) and decitabine (DEC), have been shown to improve survival or delay disease progression in high-risk MDS.” NCT06004765 ↗

“Platzbecker et al. applied azacytidine (AZA) monotherapy to AML patients with continuous MRD positive after combined chemotherapy.” NCT05361057 ↗

“Standard azacytidine treatment (AZA; D1-D7, 75mg/m2 qd)” NCT05431257 ↗

Known as AZC “Azacitidine (AZC)” NCT01812252 ↗
1

“Azacitidine (AZC)” NCT06773208 ↗

Known as CC-486 “VIALE-M is a randomized, double-blind, two-arm study to evaluate the safety and efficacy of venetoclax in combination with oral azacitidine (CC-486) as maintenance therapy in...” PMID 35852098 ↗ Jul 2022
7

“The purpose of this study is to evaluate the standard treatment, azacitidine (Vidaza) given as an injection under the skin compared to the same medication (called CC-486) taken...” NCT03493646 ↗

“Onureg (CC-486, oral azacitidine) will be administered orally at 200 or 300 mg once daily for 7 or 14 consecutive days, beginning on Day 1 of repeated 28-day cycles.” NCT05782127 ↗

“a regimen combining oral azacitidine (CC-486) and nivolumab in patients with Hodgkin lymphoma (HL) refractory to PD1/PD-L1 therapy.” NCT05162976 ↗

“CC-486 (5-azacitidine) with a dose of 300mg oral intake daily will be given on day 1 to day 10 for 6 cycles.” NCT04447027 ↗

“Oral Azacitidine (CC-486) Epigenetic Priming and Maintenance for Adult Acute Myeloid Leukemia (AML) Patients” NCT06180863 ↗

“with oral azacitidine (CC-486)-CHO(E)P vs CHO(E)P in previously untreated peripheral T-cell lymphomas” NCT04803201 ↗

“Oral azacitidine (CC-486) 200 mg tablet” NCT04173533 ↗

Known as Onureg “Study Evaluating the Efficacy and Safety of the Addition of Ivosidenib to Oral Azacitidine (Onureg®) in Patients Over 55 With Acute Myeloid Leukemia (AML) and IDH1 Mutation, in...” NCT07463768 ↗
2

NCT05209295 ↗

NCT05782127 ↗

Known as Oral Azacitidine “Oral Azacitidine, 300mg PO Daily during days 1-14 of a 28 day cycle for up to 6 cycles.” NCT06370000 ↗
Known as Oral-AZA “In the phase 3 QUAZAR AML-001 trial (NCT01757535) of patients with acute myeloid leukaemia (AML) in remission following intensive chemotherapy (IC) and ineligible for...” PMID 37952982 ↗ Nov 2023
Known as Vidaza “The purpose of this study is to determine if the addition of a drug called azacitidine (Vidaza®)when added to carboplatin and paclitaxel will change the genetic material of the...” NCT00842582 ↗
18

“Treatment of Imminent Haematological Relapse in Patients With AML and MDS Following Allogeneic Stem Cell Transplantation With 5-azacitidine (Vidaza®)” NCT00422890 ↗

“A Phase I/II Study of the Efficacy and Safety of an Intensified Schedule of Azacitidine (Vidaza®) in Intermediate-2 and High Risk MDS Patients” NCT01305460 ↗

“Azacitidine (VIDAZA) for Injection:100 mg per vial, subcutaneous injection will be administered for 7 days in each 28 day cycle” NCT04511975 ↗

“Study Examining the Combination of Revlimid (Lenalidomide)and Vidaza (Azacitidine) for Relapsed/Refractory CLL and SLL” NCT01241786 ↗

“azacitidine (also known as Vidaza®) was a current standard of care treatment option in the United States.” NCT02752035 ↗

“Hypomethylating Agent Azacitidine (Vidaza) With the Nanoparticle Albumin Bound Paclitaxel (Abraxane)” NCT00748553 ↗

“Azacitidine (VIDAZA) (100 mg SQ daily on days 1-5 of each cycle, every 21 days)” NCT03182894 ↗

“Azacitidine (Vidaza®) will be administered similarly to group 1 exposed above.” NCT01342692 ↗

“Patients in treatment arm C will be receiving low-dose azacitidine (Vidaza).” NCT01453140 ↗

“low dose Vidaza® (azacitidine)” NCT01379274 ↗

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Known as Vidaza (azacitidine) “Vidaza (azacitidine)” NCT01011283 ↗
1

“Vidaza (azacitidine)” NCT01488565 ↗

Action Inhibit “Determine the minimal effective pharmacologic dose of azacitidine required to consistently inhibit DNA methyltransferase” NCT00004871 ↗
Modality Other / unclassified “the demethylating agent 5-azacytidine” NCT01015352 ↗