drugset / Trial / NCT07132684
Comparison of VA and D/IA Induction Regimens in Elderly Fit Acute Myeloid Leukemia Patients
RandomizedParallel-groupOpen-labelTreatment
Summary
This study is a multicenter, randomized, controlled phase III clinical trial aimed at comparing the efficacy of two induction chemotherapy regimens-VA (Venetoclax + Azacitidine) and D/IA (Daunorubicin/Idarubicin + Cytarabine)-in elderly patients (aged 55-75) with acute myeloid leukemia (AML) who are fit for intensive chemotherapy.
Timeline
- Start
- 2025-08-31
- Primary completion
- 2027-08-30
- Completion
- 2028-08-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Azacitidine | Other / unclassified | 75 mg/m2 | — |
| Subject | Cytarabine | Small molecule | 100 mg/m2 | — |
| Comparator | Daunorubicin | Small molecule | 30 mg/m2 | — |
| Comparator | Idarubicin | Small molecule | 8 mg/m2 | — |
| Subject | Venetoclax | Small molecule | 400 mg | — |