drugset / Trial / NCT07672262

VA Consolidation in Intermediate-Risk AML

NCT07672262

Phase 2 Recruiting 226 enrolled The First Affiliated Hospital of Soochow University
RandomizedParallel-groupOpen-labelTreatment

Summary

This clinical trial aims to compare the efficacy and safety of venetoclax-based consolidation therapy versus conventional consolidation chemotherapy (intermediate/high-dose cytarabine) in newly diagnosed adult patients with intermediate-risk acute myeloid leukemia (AML). Participants must have achieved complete remission (CR) or CR with incomplete hematologic recovery (CRi) after induction therapy with venetoclax and azacitidine and are planned to undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Timeline

Start
2026-06-01
Primary completion
2030-06-01
Completion
2030-06-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Azacitidine Other / unclassified 75 mg/m2 Subcutaneous
Comparator Cytarabine Small molecule 1 g Intravenous
Comparator Cytarabine Small molecule 2 g Intravenous
Comparator Cytarabine Small molecule 6 g Intravenous
Subject Venetoclax Small molecule 400 mg Oral